Journal ArticleDOI
Feedback control of mitosis in budding yeast.
Rong Li,Andrew W. Murray +1 more
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TLDR
The role of feedback controls in coordinating events in the cell cycle is discussed and the properties of mad mutants indicate that they are defective in the feedback control over the exit from mitosis are discussed.About:
This article is published in Cell.The article was published on 1991-08-09. It has received 1252 citations till now. The article focuses on the topics: Mitotic exit & Mitosis.read more
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Cell cycle control and cancer
TL;DR: New insights in understanding of the cell cycle reveal how fidelity is normally achieved by the coordinated activity of cyclin-dependent kinases, checkpoint controls, and repair pathways and how this fidelity can be abrogated by specific genetic changes.
Journal ArticleDOI
The spindle-assembly checkpoint in space and time.
TL;DR: Recent molecular analyses have begun to shed light on the complex interaction of the checkpoint proteins with kinetochores — structures that mediate the binding of spindle microtubules to chromosomes in mitosis.
Journal ArticleDOI
Cell Cycle Checkpoints: Preventing an Identity Crisis
TL;DR: Signal transduction pathways that transmit checkpoint signals in response to DNA damage, replication blocks, and spindle damage are revealed, underscoring the conservation of cell cycle regulatory machinery.
Journal ArticleDOI
p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.
Kornelia Polyak,Jun-ya Kato,Mark J. Solomon,Charles J. Sherr,Joan Massagué,James M. Roberts,Andrew Koff +6 more
TL;DR: Cyclin D2-Cdk4 complexes bind competitively to and down-regulate the activity of p27 and may thereby act in a pathway that reverses Cdk2 inhibition and enables G1 progression.
Journal ArticleDOI
Mutations of mitotic checkpoint genes in human cancers
Daniel P. Cahill,Christoph Lengauer,Jian Yu,Gregory J. Riggins,James K V Willson,Sanford D. Markowitz,Kenneth W. Kinzler,Bert Vogelstein +7 more
TL;DR: It is shown that CIN is consistently associated with the loss of function of a mitotic checkpoint in cancers displaying CIN, and in some cancersThe loss of this checkpoint wasassociated with the mutational inactivation of a human homologue of the yeast BUB1 gene; BUB 1 controls mitotic checkpoints and chromosome segregation in yeast.
References
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Journal ArticleDOI
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
TL;DR: This assay is very reproducible and rapid with the dye binding process virtually complete in approximately 2 min with good color stability for 1 hr with little or no interference from cations such as sodium or potassium nor from carbohydrates such as sucrose.
Journal ArticleDOI
Detection of specific sequences among DNA fragments separated by gel electrophoresis.
TL;DR: This paper describes a method of transferring fragments of DNA from agarose gels to cellulose nitrate filters that can be hybridized to radioactive RNA and hybrids detected by radioautography or fluorography.
Journal ArticleDOI
A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae.
Robert S. Sikorski,Philip Hieter +1 more
TL;DR: A series of yeast shuttle vectors and host strains has been created to allow more efficient manipulation of DNA in Saccharomyces cerevisiae to perform most standard DNA manipulations in the same plasmid that is introduced into yeast.
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S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.
M.A. Hoyt,L. Totis,B.T. Roberts +2 more