R
Rory Stark
Researcher at University of Cambridge
Publications - 27
Citations - 6209
Rory Stark is an academic researcher from University of Cambridge. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 20, co-authored 27 publications receiving 4957 citations.
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Book ChapterDOI
Differential oestrogen receptor binding is associated with clinical outcome in breast cancer
TL;DR: DiffBind is used to identify ERα sites significantly differentially bound between those found in tumours from patients with good prognosis vs. those with poor prognosis and metastases, and to show the plasticity of ERα binding capacity.
Journal ArticleDOI
RNA sequencing: the teenage years
TL;DR: Advances in RNA-sequencing technologies and methods over the past decade are discussed and adaptations that are enabling a fuller understanding of RNA biology are outlined, from when and where an RNA is expressed to the structures it adopts.
Journal ArticleDOI
The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis
Charles E. Massie,Andy G. Lynch,Antonio Ramos-Montoya,Joan Boren,Rory Stark,Ladan Fazli,Anne Y. Warren,H Scott,Basetti Madhu,N L Sharma,Helene Bon,Vinny Zecchini,D. Smith,Gina M. DeNicola,Nik Mathews,Michelle Osborne,James Hadfield,Stewart MacArthur,Boris Adryan,Scott K. Lyons,Kevin M. Brindle,John R. Griffiths,Martin E. Gleave,Paul S. Rennie,David E. Neal,Ian G. Mills +25 more
TL;DR: Cal calcium/calmodulin‐dependent protein kinase kinase 2 is highlighted, which it is shown is overexpressed in prostate cancer and regulates cancer cell growth via its unexpected role as a hormone‐dependent modulator of anabolic metabolism.
Journal ArticleDOI
Progesterone receptor modulates ERα action in breast cancer
Hisham Mohammed,I. Alasdair Russell,Rory Stark,Oscar M. Rueda,Theresa E. Hickey,Gerard A. Tarulli,Aurélien A. Sérandour,Stephen N. Birrell,Alejandra Bruna,Amel Saadi,Suraj Menon,James Hadfield,Michelle Pugh,Ganesh V. Raj,Gordon D Brown,Clive D'Santos,Jessica L. L. Robinson,Grace O. Silva,Rosalind Launchbury,Charles M. Perou,John Stingl,Carlos Caldas,Wayne D. Tilley,Jason S. Carroll +23 more
TL;DR: Progesterone receptor (PR) expression is used as a biomarker of oestrogen receptor-α (ERα) function and breast cancer prognosis as mentioned in this paper, which has important implications for prognosis and therapeutic interventions.
Journal ArticleDOI
Piwi and piRNAs Act Upstream of an Endogenous siRNA Pathway to Suppress Tc3 Transposon Mobility in the Caenorhabditis elegans Germline
Partha Pratim Das,Partha Pratim Das,Partha Pratim Das,Marloes P. Bagijn,Marloes P. Bagijn,Leonard D. Goldstein,Julie R. Woolford,Julie R. Woolford,Nicolas J. Lehrbach,Nicolas J. Lehrbach,Alexandra Sapetschnig,Alexandra Sapetschnig,Heeran R. Buhecha,Heeran R. Buhecha,Michael J. Gilchrist,Kevin L. Howe,Rory Stark,Nik Matthews,Eugene Berezikov,René F. Ketting,Simon Tavaré,Eric A. Miska,Eric A. Miska +22 more
TL;DR: It is demonstrated that Piwi acts upstream of an endogenous siRNA pathway in Tc3 silencing, which might suggest a link between piRNA and siRNA function.