R
Roshan M. Kumar
Researcher at Massachusetts Institute of Technology
Publications - 25
Citations - 9792
Roshan M. Kumar is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Cellular differentiation & Regulation of gene expression. The author has an hindex of 14, co-authored 25 publications receiving 9300 citations. Previous affiliations of Roshan M. Kumar include Wyss Institute for Biologically Inspired Engineering & Harvard University.
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Journal ArticleDOI
Core transcriptional regulatory circuitry in human embryonic stem cells.
Laurie A. Boyer,Tong Ihn Lee,Megan F. Cole,Sarah E. Johnstone,Stuart S. Levine,Jacob P. Zucker,Matthew G. Guenther,Roshan M. Kumar,Heather L. Murray,Richard G. Jenner,David K. Gifford,David K. Gifford,David K. Gifford,Douglas A. Melton,Douglas A. Melton,Rudolf Jaenisch,Richard A. Young,Richard A. Young +17 more
TL;DR: Insight is provided into the transcriptional regulation of stem cells and how OCT4, SOX2, and NANOG contribute to pluripotency and self-renewal and how they collaborate to form regulatory circuitry consisting of autoregulatory and feedforward loops.
Journal ArticleDOI
Control of developmental regulators by Polycomb in human embryonic stem cells.
Tong Ihn Lee,Richard G. Jenner,Laurie A. Boyer,Matthew G. Guenther,Stuart S. Levine,Roshan M. Kumar,Brett Chevalier,Sarah E. Johnstone,Megan F. Cole,Kyoichi Isono,Haruhiko Koseki,Takuya Fuchikami,Kuniya Abe,Heather L. Murray,Jacob P. Zucker,Bingbing Yuan,George W. Bell,Elizabeth Herbolsheimer,Nancy M. Hannett,Kaiming Sun,Duncan T. Odom,Arie P. Otte,Thomas L. Volkert,David P. Bartel,Douglas A. Melton,David K. Gifford,David K. Gifford,Rudolf Jaenisch,Richard A. Young +28 more
TL;DR: It is found that PRC2 target genes are preferentially activated during ES cell differentiation and that the ES cell regulators OCT4, SOX2, and NANOG cooccupy a significant subset of these genes.
Journal ArticleDOI
Myogenic factors that regulate expression of muscle-specific microRNAs
TL;DR: This work suggests that induction of these microRNAs is important in regulating the expression of muscle-specific proteins, and demonstrates that the myogenic factors Myogenin and MyoD bind to regions upstream of thesemicroRNAs and are likely to regulate their expression.
Journal ArticleDOI
Master transcription factors determine cell-type-specific responses to TGF-β signaling.
Alan C. Mullen,David A. Orlando,Jamie J. Newman,Jakob Lovén,Roshan M. Kumar,Steve Bilodeau,Jessica Reddy,Matthew G. Guenther,Rodney P. DeKoter,Richard A. Young +9 more
TL;DR: It is concluded that cell-type-specific master transcription factors determine the genes bound by Smad2/3 and are thus responsible for orchestrating the cell- type-specific effects of TGF-β signaling.
Journal ArticleDOI
Deconstructing transcriptional heterogeneity in pluripotent stem cells
Roshan M. Kumar,Patrick Cahan,Alex K. Shalek,Rahul Satija,AJay DaleyKeyser,Hu Li,Jin Zhang,Keith Pardee,Keith Pardee,David Gennert,John J. Trombetta,Thomas C. Ferrante,Aviv Regev,Aviv Regev,George Q. Daley,James J. Collins,James J. Collins +16 more
TL;DR: In this paper, the authors characterize transcriptional heterogeneity in Pluripotent Stem Cells (PSCs) by single-cell single-input single-out (SISO) experiments.