R
Rudolf Uher
Researcher at Dalhousie University
Publications - 350
Citations - 28239
Rudolf Uher is an academic researcher from Dalhousie University. The author has contributed to research in topics: Major depressive disorder & Bipolar disorder. The author has an hindex of 77, co-authored 314 publications receiving 23342 citations. Previous affiliations of Rudolf Uher include Karolinska Institutet & Duke University.
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Journal ArticleDOI
Genetic counselling for the prevention of mental health consequences of cannabis use: A randomized controlled trial-within-cohort.
Alyson Zwicker,Alyson Zwicker,Marissa A. LeBlanc,Barbara Pavlova,Barbara Pavlova,Martin Alda,Martin Alda,Eileen M. Denovan-Wright,Rudolf Uher,Rudolf Uher,Jehannine Austin +10 more
TL;DR: This study represents the first translational application of a gene-environment interaction to improve mental health and test an intervention with potential public health benefits.
Posted ContentDOI
Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: meta-analysis of data from genome-wide association studies
Chiara Fabbri,Katherine E. Tansey,Roy H. Perlis,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Gerome Breen,Charles Curtis,Sang Hyuk Lee,Stephen Newhouse,Hamel Patel,Michael Conlon O'Donovan,Glyn Lewis,Gregory D. Jenkins,Richard M. Weinshilboum,Anne Farmer,Katherine J. Aitchison,Ian W. Craig,Peter McGuffin,Koen Schruers,Joanna M. Biernacka,Rudolf Uher,Cathryn M. Lewis +26 more
TL;DR: CYP2C19 polymorphisms may provide helpful information for guiding citalopram/escitaloprams treatment, despite PMs are relatively rare among Caucasians (~2%).
Journal ArticleDOI
Antidepressant effects of nortriptyline and escitalopram in the GENDEP study: Is one better than the other?
TL;DR: An independent reanalysis of data from the Genome-based Therapeutic Drugs for Depression study suggests that escitalopram may be superior to nortriptyline in its effect on core depressive symptoms, which differs from the conclusion that the two antidepressants do not differ in overall antidepressant efficacy.
Posted ContentDOI
A polygenic predictor of treatment-resistant depression using whole exome sequencing and genome-wide genotyping
Chiara Fabbri,Siegfried Kasper,Alexander Kautzky,Joseph Zohar,Daniel Souery,Stuart Montgomery,Diego Albani,Gianluigi Forloni,Panagiotis Ferentinos,Dan Rujescu,Julien Mendlewicz,Rudolf Uher,Cathryn M. Lewis,Alessandro Serretti +13 more
TL;DR: Genes/pathways associated with TRD included those modulating cell survival and proliferation, neurodegeneration and immune response and some models were replicated, with a weaker prediction, in STAR*D and GENDEP when considering also clinical factors and in the extremes of the genetic score distribution.
Journal ArticleDOI
The Differential Relation of Emotional, Physical, and Sexual Abuse Histories to Antidepressant Treatment Remission and Persistence of Anhedonia in Major Depression: A CAN-BIND-1 Report.
Kate L. Harkness,Trisha Chakrabarty,Sakina J. Rizvi,Raegan Mazurka,Lena C. Quilty,Rudolf Uher,Roumen Milev,Benicio N. Frey,Sagar V. Parikh,Jane A. Foster,Susan Rotzinger,Sidney H. Kennedy,Raymond W. Lam +12 more
TL;DR: In this paper , a multicentre clinical trial of major depression, 164 individuals were assessed for childhood emotional, physical, and sexual maltreatment with a contextual interview with independent, standardized ratings.