R
Rudolf Uher
Researcher at Dalhousie University
Publications - 350
Citations - 28239
Rudolf Uher is an academic researcher from Dalhousie University. The author has contributed to research in topics: Major depressive disorder & Bipolar disorder. The author has an hindex of 77, co-authored 314 publications receiving 23342 citations. Previous affiliations of Rudolf Uher include Karolinska Institutet & Duke University.
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Journal ArticleDOI
Adversity, parental mental illness, and risk of depression in youth
Victoria C. Patterson,Lynn E. MacKenzie,Alyson Zwicker,Vladislav Drobinin,Jill Cumby,Sabina Abidi,Alexa Bagnell,Lukas Propper,Martin Alda,Rudolf Uher +9 more
TL;DR: Adversity, such as maltreatment and bullying, has a stronger impact on the risk of developing depression than family history of mental illness in parents, and these adverse experiences are associated with socioeconomic status rather than parental mental illness.
Posted ContentDOI
New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation
Chiara Fabbri,Katherine E. Tansey,Roy H. Perlis,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Gerome Breen,Charles Curtis,Lee Sang-Hyuk,Stephen Newhouse,Hamel Patel,Michel Guipponi,Nader Perroud,Guido Bondolfi,Michael Conlon O'Donovan,Glyn Lewis,Joanna M. Biernacka,Richard M. Weinshilboum,Anne Farmer,Katherine J. Aitchison,Ian W. Craig,Peter McGuffin,Rudolf Uher,Cathryn M. Lewis +27 more
TL;DR: A meta-analysis of Genome-Based Therapeutic Drugs for Depression (GENDEP) and Sequenced Treatment Alternatives to Relieve Depression (STAR*D) studies was performed at SNP, gene and pathway level, and two SNPs were significantly associated with symptom improvement during citaloprams/escitalopram treatment.
Journal ArticleDOI
Decision-making and ‘gut feeling’ in males with anorexia nervosa
Kate Tchanturia,Hannah Curtis,Thomas Pei-Chi Liao,Rudolf Uher,Ulrike Schmidt,Iain C. Campbell +5 more
TL;DR: Impaired performance in the IGT in male patients with anorexia nervosa is not associated with diminished somatic responses and clinical severity, which shows that impaired decision-making is present in both male and female patients with AN.
Journal ArticleDOI
Replication of machine learning methods to predict treatment outcome with antidepressant medications in patients with major depressive disorder from STAR*D and CAN-BIND-1.
John-Jose Nunez,Teyden T. Nguyen,Yihan Zhou,Bo Cao,Raymond T. Ng,Jun Chen,Benicio N. Frey,Roumen Milev,Daniel J. Müller,Susan Rotzinger,Claudio N. Soares,Rudolf Uher,Sidney H. Kennedy,Raymond W. Lam +13 more
TL;DR: In this paper, Nie et al. used linear regressions and decision trees to predict treatment resistant depression (TRD, defined as failing to respond to 2 or more antidepressants) in the STAR*D dataset, and externally validated these methods to train models using data from the CAN-BIND-1 dataset.
Journal ArticleDOI
Applications of Speech Analysis in Psychiatry
TL;DR: The authors identified four domains of the application of speech analysis in the literature: diagnostic classification, assessment of illness severity, prediction of onset of illness, and prognosis and treatment outcomes, with a focus on how types of speech features characterize different aspects of psychopathology.