R
Rudolf Uher
Researcher at Dalhousie University
Publications - 350
Citations - 28239
Rudolf Uher is an academic researcher from Dalhousie University. The author has contributed to research in topics: Major depressive disorder & Bipolar disorder. The author has an hindex of 77, co-authored 314 publications receiving 23342 citations. Previous affiliations of Rudolf Uher include Karolinska Institutet & Duke University.
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Journal ArticleDOI
Genetic differences in cytochrome P450 enzymes and antidepressant treatment response
Karen Hodgson,Katherine E. Tansey,Mojca Z. Dernovsek,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Robert Peter Smith,Ian W. Craig,Anne Farmer,Katherine J. Aitchison,Katherine J. Aitchison,Sarah S. Belsy,Oliver S. P. Davis,Oliver S. P. Davis,Rudolf Uher,Rudolf Uher,Peter McGuffin +20 more
TL;DR: While there is a significant relationship between the CYP450 genotype and serum concentrations of escitalopram and nortriptyline, the genotypes are not predictive of differences in treatment response for either drug.
Journal ArticleDOI
Pharmacogenetics of antidepressant response: a polygenic approach
Judit García-González,Katherine E. Tansey,Joanna Hauser,Neven Henigsberg,Wolfgang Maier,Ole Mors,Anna Placentino,Marcella Rietschel,Daniel Souery,Tina Žagar,Piotr M. Czerski,Borut Jerman,Henriette N. Buttenschøn,Thomas G. Schulze,Astrid Zobel,Anne Farmer,Katherine J. Aitchison,Ian W. Craig,Peter McGuffin,Michel Giupponi,Nader Perroud,Guido Bondolfi,David M. Evans,Michael Conlon O'Donovan,Tim J Peters,Jens R. Wendland,Glyn Lewis,Shitij Kapur,Roy H. Perlis,Volker Arolt,Katharina Domschke,Gerome Breen,Charles Curtis,Lee Sang-Hyuk,Carol Kan,Stephen Newhouse,Hamel Patel,Bernhard T. Baune,Rudolf Uher,Cathryn M. Lewis,Chiara Fabbri +40 more
TL;DR: The genetic liability to MDD or schizophrenia did not predict response to antidepressants, suggesting differences between the genetic component of depression and treatment response, and larger or more homogeneous studies will be necessary to obtain a polygenic predictor of antidepressant response.
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A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness
Rudolf Uher,Jill Cumby,Lynn E. MacKenzie,Lynn E. MacKenzie,Jessica Morash-Conway,Jacqueline M. Glover,Alice Aylott,Alice Aylott,Lukas Propper,Lukas Propper,Sabina Abidi,Sabina Abidi,Alexa Bagnell,Alexa Bagnell,Barbara Pavlova,Barbara Pavlova,Tomas Hajek,Tomas Hajek,David Lovas,David Lovas,Kathleen Pajer,Kathleen Pajer,William Gardner,William Gardner,Adrian R. Levy,Martin Alda,Martin Alda +26 more
TL;DR: Families Overcoming Risks and Building Opportunities for Well-being (FORBOW) is an accelerated cohort study that includes a large proportion of offspring of parents with SMI and embeds intervention trials in a cohort multiple randomized controlled trial (cmRCT) design.
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Obesity, dyslipidemia and brain age in first-episode psychosis.
Marian Kolenic,Katja Franke,Jaroslav Hlinka,Martin Matejka,Jana Capkova,Zdenka Pausova,Rudolf Uher,Martin Alda,Filip Spaniel,Tomas Hajek,Tomas Hajek +10 more
TL;DR: Overweight/obesity may be an independent risk factor for diffuse brain alterations manifesting as advanced brain age already early in the course of psychosis, raising the possibility that targeting metabolic health and intervening already at the level of overweight/ob obesity could slow brain ageing in FEP.
Journal ArticleDOI
Interaction between stress and the BDNF Val66Met polymorphism in depression: A systematic review and meta-analysis
Georgina M. Hosang,Georgina M. Hosang,Celia J. Shiles,Katherine E. Tansey,Katherine E. Tansey,Peter McGuffin,Rudolf Uher,Rudolf Uher +7 more
TL;DR: This article conducted a meta-analysis on the results from published studies examining the relationship between life stress and Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene.