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Rui Benfeitas
Researcher at Science for Life Laboratory
Publications - 41
Citations - 3224
Rui Benfeitas is an academic researcher from Science for Life Laboratory. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 12, co-authored 30 publications receiving 2002 citations. Previous affiliations of Rui Benfeitas include University of Coimbra & Royal Institute of Technology.
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A pathology atlas of the human cancer transcriptome
Mathias Uhlén,Mathias Uhlén,Cheng Zhang,Sunjae Lee,Evelina Sjöstedt,Evelina Sjöstedt,Linn Fagerberg,Gholamreza Bidkhori,Rui Benfeitas,Muhammad Arif,Zhengtao Liu,Fredrik Edfors,Kemal Sanli,Kalle von Feilitzen,Per Oksvold,Emma Lundberg,Sophia Hober,Peter Nilsson,Johanna Sofia Margareta Mattsson,Jochen M. Schwenk,Hans Brunnström,Bengt Glimelius,Tobias Sjöblom,Per-Henrik Edqvist,Dijana Djureinovic,Patrick Micke,Cecilia Lindskog,Adil Mardinoglu,Adil Mardinoglu,Fredrik Pontén +29 more
TL;DR: A Human Pathology Atlas has been created as part of the Human Protein Atlas program to explore the prognostic role of each protein-coding gene in 17 different cancers, and reveals that gene expression of individual tumors within a particular cancer varied considerably and could exceed the variation observed between distinct cancer types.
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Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells.
Sofia Appelberg,Soham Gupta,Sara Svensson Akusjärvi,Anoop T. Ambikan,Flora Mikaeloff,Elisa Saccon,Ákos Végvári,Rui Benfeitas,Maike Sperk,Marie Ståhlberg,Shuba Krishnan,Kamal Singh,Kamal Singh,Josef M. Penninger,Josef M. Penninger,Ali Mirazimi,Ali Mirazimi,Ali Mirazimi,Ujjwal Neogi,Ujjwal Neogi +19 more
TL;DR: An integrative proteo-transcriptomics analysis in Sars-CoV-2 infected Huh7 cells to map the cellular response to the invading virus over time identified four pathways, ErbB, HIF-1, mTOR and TNF signaling, among others that were markedly modulated during the course of the SARS-Cov-2 infection in vitro.
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Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.
Gholamreza Bidkhori,Gholamreza Bidkhori,Rui Benfeitas,Martina Klevstig,Martina Klevstig,Cheng Zhang,Jens Nielsen,Mathias Uhlén,Jan Borén,Jan Borén,Adil Mardinoglu,Adil Mardinoglu,Adil Mardinoglu +12 more
TL;DR: The analyses showed that the heterogeneous HCC tumors can be stratified using a metabolic network-driven approach, which may also be applied to other cancer types, and this stratification may have clinical implications to drive the development of precision medicine.
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Hydrogen peroxide metabolism and sensing in human erythrocytes: A validated kinetic model and reappraisal of the role of peroxiredoxin II
TL;DR: Simulations of the responses of intact erythrocytes to physiological H2O2 stimuli highlight that a design combining abundant Prx2 with a low effective peroxidase activity spares NADPH while improving potential signaling properties of the Prx 2/thioredoxin/thIoredoxin reductase system.
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Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning
Beste Turanli,Cheng Zhang,Woong-Hee Kim,Rui Benfeitas,Mathias Uhlén,Kazim Yalcin Arga,Adil Mardinoglu,Adil Mardinoglu,Adil Mardinoglu +8 more
TL;DR: This study reconstructs a prostate cancer (PRAD)-specific GEM and finds that sulfamethoxypyridazine, azlocillin, hydroflumethiazide, and ifenprodil can be repurposed for the treatment of prostate cancer based on an in silico cell viability assay.