S
S. Hong Lee
Researcher at University of South Australia
Publications - 6
Citations - 1094
S. Hong Lee is an academic researcher from University of South Australia. The author has contributed to research in topics: Attention deficit hyperactivity disorder & Population. The author has an hindex of 6, co-authored 6 publications receiving 771 citations. Previous affiliations of S. Hong Lee include University of New England (Australia) & University of Queensland.
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Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases | NOVA. The University of Newcastle's Digital Repository
Alexander Gusev,S. Hong Lee,Anna K. Kähler,Christina M. Hultman,Shaun Purcell,Steven A. McCarroll,Mark Daly,Bogdan Pasaniuc,Patrick F. Sullivan,Benjamin M. Neale,Naomi R. Wray,Soumya Raychaudhuri,Gosia Trynka,Alkes L. Price,Hilary K. Finucane,Bjarni J. Vilhjálmsson,Han Xu,Chongzhi Zang,Stephan Ripke,Brendan K. Bulik-Sullivan,E Stahl +20 more
TL;DR: These results highlight the value of analyzing components of heritability to unravel the functional architecture of common disease and find no significant contribution from rare coding variants in independent schizophrenia cohorts genotyped on GWAS and exome chips.
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Genetic correlations of polygenic disease traits: from theory to practice
TL;DR: Improved methodologies have enabled genetic correlations to be estimated for almost any trait pair, which can improve the understanding of the shared biology and causal relationships between traits.
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RICOPILI: Rapid Imputation for COnsortias PIpeLIne.
Max Lam,Swapnil Awasthi,Swapnil Awasthi,Hunna J. Watson,Hunna J. Watson,Hunna J. Watson,Jackie Goldstein,Jackie Goldstein,Georgia Panagiotaropoulou,Georgia Panagiotaropoulou,Vassily Trubetskoy,Vassily Trubetskoy,Robert Karlsson,Oleksandr Frei,Chun Chieh Fan,W. De Witte,Nina Roth Mota,Niamh Mullins,Kim Brügger,S. Hong Lee,Naomi R. Wray,Nora Skarabis,Hailiang Huang,Hailiang Huang,Benjamin M. Neale,Benjamin M. Neale,Mark J. Daly,Mark J. Daly,Manuel Mattheisen,Manuel Mattheisen,Raymond K. Walters,Raymond K. Walters,Stephan Ripke,Stephan Ripke,Stephan Ripke +34 more
TL;DR: RICOPILI, an open-sourced Perl-based pipeline was developed to address the challenges of rapidly processing large-scale multi-cohort GWAS studies including quality control, imputation and downstream analyses, is computationally efficient with portability to a wide range of high-performance computing environments.
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A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder
Joanna Martin,Raymond K. Walters,Ditte Demontis,Manuel Mattheisen,S. Hong Lee,Elise B. Robinson,Isabell Brikell,Laura Ghirardi,Henrik Larsson,Paul Lichtenstein,Nicholas Eriksson,iPSYCH–Broad Adhd Workgroup,Thomas Werge,Preben Bo Mortensen,Marianne Giørtz Pedersen,Ole Mors,Merete Nordentoft,David M. Hougaard,Jonas Bybjerg-Grauholm,Naomi R. Wray,Barbara Franke,Stephen V. Faraone,Michael Conlon O'Donovan,Anita Thapar,Anders D. Børglum,Benjamin M. Neale +25 more
TL;DR: This study supports a greater familial burden of risk in female individuals with ADHD and some clinical and etiological heterogeneity, based on epidemiological analyses, and molecular genetic analyses suggest that autosomal common variants largely do not explain the sex bias in ADHD prevalence.
Posted ContentDOI
A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder
Joanna Martin,Raymond K. Walters,Ditte Demontis,Manuel Mattheisen,S. Hong Lee,Elise B. Robinson,Isabell Brikell,Laura Ghirardi,Henrik Larsson,Paul Lichtenstein,Nicholas Eriksson,iPSYCH–Broad Adhd Workgroup,iPSYCH–Broad Adhd Workgroup,Thomas Werge,Preben Bo Mortensen,Marianne Giørtz Pedersen,Ole Mors,Merete Nordentoft,David M. Hougaard,Jonas Bybjerg-Grauholm,Naomi R. Wray,Barbara Franke,Stephen V. Faraone,Michael Conlon O'Donovan,Anita Thapar,Anders D. Børglum,Benjamin M. Neale +26 more
TL;DR: This study analyzes genome-wide common variants from the Psychiatric Genomics Consortium and iPSYCH Project and Swedish population-registry data to find strong genetic correlation for ADHD across sex and no mean difference in polygenic burden across sex.