S
Sadegh Saghafinia
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 20
Citations - 2740
Sadegh Saghafinia is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 7, co-authored 9 publications receiving 1581 citations. Previous affiliations of Sadegh Saghafinia include University of Lausanne & ISREC.
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Journal ArticleDOI
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega,Marco Mina,Joshua Armenia,Walid K. Chatila,Augustin Luna,Konnor La,Sofia Dimitriadoy,David L. Liu,Havish S. Kantheti,Sadegh Saghafinia,Debyani Chakravarty,Foysal Daian,Qingsong Gao,Matthew H. Bailey,Wen-Wei Liang,Steven M. Foltz,Ilya Shmulevich,Li Ding,Zachary J. Heins,Angelica Ochoa,Benjamin Gross,Jianjiong Gao,Hongxin Zhang,Ritika Kundra,Cyriac Kandoth,Istemi Bahceci,Leonard Dervishi,Ugur Dogrusoz,Wanding Zhou,Hui Shen,Peter W. Laird,Gregory P. Way,Casey S. Greene,Han Liang,Yonghong Xiao,Chen Wang,Antonio Iavarone,Alice H. Berger,Trever G. Bivona,Alexander J. Lazar,Gary D. Hammer,Thomas J. Giordano,Lawrence N. Kwong,Grant A. McArthur,Chenfei Huang,Aaron D. Tward,Mitchell J. Frederick,Frank McCormick,Matthew Meyerson,Eliezer M. Van Allen,Andrew D. Cherniack,Giovanni Ciriello,Chris Sander,Nikolaus Schultz +53 more
TL;DR: This work charted the detailed landscape of pathway alterations in 33 cancer types, stratified into 64 subtypes, and identified patterns of co-occurrence and mutual exclusivity.
Journal ArticleDOI
Synaptic proximity enables NMDAR signalling to promote brain metastasis
Qiqun Zeng,Iacovos P. Michael,Peng Zhang,Sadegh Saghafinia,Graham Knott,Wei Jiao,Brian D. McCabe,José A. Galván,Hugh P. C. Robinson,Inti Zlobec,Giovanni Ciriello,Giovanni Ciriello,Douglas Hanahan +12 more
TL;DR: It is shown that B2BM cells co-opt a neuronal signalling pathway that was recently implicated in invasive tumour growth, involving activation by glutamate ligands of N-methyl-d-aspartate receptors (NMDARs), which is key in model systems for metastatic colonization of the brain and is associated with poor prognosis.
Journal ArticleDOI
Pan-Cancer Landscape of Aberrant DNA Methylation across Human Tumors.
Sadegh Saghafinia,Sadegh Saghafinia,Sadegh Saghafinia,Marco Mina,Marco Mina,Nicolo Riggi,Douglas Hanahan,Giovanni Ciriello,Giovanni Ciriello +8 more
TL;DR: An algorithmic approach (RESET) is designed to identify aberrant DNA methylation and associated cis-transcriptional changes across >6,000 human tumors and provides a pan-cancer map of aberrantDNA methylation to inform functional and therapeutic studies.
Journal ArticleDOI
Metabolic Symbiosis Enables Adaptive Resistance to Anti-angiogenic Therapy that Is Dependent on mTOR Signaling
Elizabeth Allen,Pascal Miéville,Carmen M. Warren,Sadegh Saghafinia,Leanne Li,Mei-Wen Peng,Douglas Hanahan,Douglas Hanahan +7 more
TL;DR: Therapeutic targeting of tumor angiogenesis with VEGF inhibitors results in demonstrable, but transitory efficacy in certain human tumors and mouse models of cancer, limited by unconventional forms of adaptive/evasive resistance.
Journal ArticleDOI
Conditional Selection of Genomic Alterations Dictates Cancer Evolution and Oncogenic Dependencies.
Marco Mina,Marco Mina,Franck Raynaud,Franck Raynaud,Daniele Tavernari,Daniele Tavernari,Elena Battistello,Elena Battistello,Elena Battistello,Stephanie Sungalee,Sadegh Saghafinia,Sadegh Saghafinia,Sadegh Saghafinia,Titouan Laessle,Francisco Sanchez-Vega,Nikolaus Schultz,Elisa Oricchio,Giovanni Ciriello,Giovanni Ciriello +18 more
TL;DR: This work designed SELECT, an algorithmic approach to systematically identify evolutionary dependencies from alteration patterns, which provides a framework for the design of strategies to predict cancer progression and therapeutic response.