S
Sara Gredmark-Russ
Researcher at Karolinska University Hospital
Publications - 32
Citations - 2504
Sara Gredmark-Russ is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Immune system & T cell. The author has an hindex of 12, co-authored 27 publications receiving 1473 citations. Previous affiliations of Sara Gredmark-Russ include Karolinska Institutet.
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Journal ArticleDOI
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Lars Eriksson,Jan-Inge Henter,Anders Sönnerborg,Tobias Allander,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +29 more
TL;DR: It is shown that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Posted ContentDOI
Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean-Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Olav Rooyackers,Lars Eriksson,Lars Eriksson,Anders Sönnerborg,Tobias Allander,Tobias Allander,Jan Albert,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +32 more
TL;DR: The collective dataset shows that SARS-CoV-2 elicits robust memory T cell responses akin to those observed in the context of successful vaccines, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19 also in seronegative individuals.
Journal ArticleDOI
MAIT cell activation and dynamics associated with COVID-19 disease severity.
Tiphaine Parrot,Jean-Baptiste Gorin,Andrea Ponzetta,Kimia T. Maleki,Tobias Kammann,Johanna Emgård,André Perez-Potti,Takuya Sekine,Olga Rivera-Ballesteros,Sara Gredmark-Russ,Olav Rooyackers,Olav Rooyackers,Elin Folkesson,Elin Folkesson,Lars Eriksson,Lars Eriksson,Anna Norrby-Teglund,Hans-Gustaf Ljunggren,Niklas K. Björkström,Soo Aleman,Soo Aleman,Marcus Buggert,Jonas Klingström,Kristoffer Strålin,Kristoffer Strålin,Johan K. Sandberg +25 more
TL;DR: Findings indicate that MAIT cells are engaged in the immune response against SARS-CoV-2 and suggest their possible involvement in COVID-19 immunopathogenesis.
Journal ArticleDOI
Major alterations in the mononuclear phagocyte landscape associated with COVID-19 severity.
Egle Kvedaraite,Egle Kvedaraite,Laura Hertwig,Indranil Sinha,Andrea Ponzetta,Ida Hed Myrberg,Magda Lourda,Magda Lourda,Majda Dzidic,Mira Akber,Jonas Klingström,Elin Folkesson,Jagadeeswara Rao Muvva,Puran Chen,Sara Gredmark-Russ,Susanna Brighenti,Anna Norrby-Teglund,Lars Eriksson,Lars Eriksson,Olav Rooyackers,Olav Rooyackers,Soo Aleman,Soo Aleman,Kristoffer Strålin,Kristoffer Strålin,Hans-Gustaf Ljunggren,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Niklas K. Björkström,Jan-Inge Henter,Jan-Inge Henter,Mattias Svensson,Karolinska Ki +33 more
Abstract: Dendritic cells (DCs) and monocytes are crucial mediators of innate and adaptive immune responses during viral infection, but misdirected responses by these cells may contribute to immunopathology. Here, we performed high-dimensional flow cytometry-analysis focusing on mononuclear phagocyte (MNP) lineages in SARS-CoV-2-infected patients with moderate and severe COVID-19. We provide a deep and comprehensive map of the MNP landscape in COVID-19. A redistribution of monocyte subsets toward intermediate monocytes and a general decrease in circulating DCs was observed in response to infection. Severe disease coincided with the appearance of monocytic myeloid-derived suppressor cell-like cells and a higher frequency of pre-DC2. Furthermore, phenotypic alterations in MNPs, and their late precursors, were cell-lineage-specific and associated either with the general response against SARS-CoV-2 or COVID-19 severity. This included an interferon-imprint in DC1s observed in all patients and a decreased expression of the coinhibitory molecule CD200R in pre-DCs, DC2s, and DC3 subsets of severely sick patients. Finally, unsupervised analysis revealed that the MNP profile, alone, pointed to a cluster of COVID-19 nonsurvivors. This study provides a reference for the MNP response to SARS-CoV-2 infection and unravels mononuclear phagocyte dysregulations associated with severe COVID-19.
Journal ArticleDOI
Expansion of SARS-CoV-2-Specific Antibody-Secreting Cells and Generation of Neutralizing Antibodies in Hospitalized COVID-19 Patients.
Renata Varnaitė,Marina García,Hedvig Glans,Kimia T Maleki,John Tyler Sandberg,Janne Tynell,Wanda Christ,Nina Lagerqvist,Hilmir Asgeirsson,Hilmir Asgeirsson,Hans-Gustaf Ljunggren,Gustaf Ahlén,Lars Frelin,Matti Sällberg,Kim Blom,Jonas Klingström,Jonas Klingström,Sara Gredmark-Russ +17 more
TL;DR: This study detected an expansion of SARS-CoV-2 nucleocapsid protein–specific Ab-secreting cells in all 20 COVID-19 patients using a multicolor FluoroSpot Assay, and showed that IL-6 and C-reactive protein serum concentrations were higher in patients who were hospitalized for longer, supporting the recent observations that IL/C- reactive protein could be used as markers for CO VID-19 severity.