Sarah J Lewis

TL;DR: A genome-wide association study using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml) identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X.

TL;DR: A small-scale qualitative study of the views and experiences of 20 pupils with Asperger syndrome drawn from four secondary schools in north-west England finds how participants constructed their understanding of what their AS meant to them was often characterized by negative perceptions of their differences.

TL;DR: The study is extended to evaluate promising associations in a second stage in which 43,671 SNPs are genotyped in 3,650 PrCa cases and 3,940 controls and in a third stage involving an additional 16,229 cases and 14,821 controls from 21 studies.

TL;DR: An association between the MTHFR C677T variant and depression, schizophrenia, and bipolar disorder is demonstrated, raising the possibility of the use of folate in treatment and prevention.

TL;DR: No strong evidence exists to support an association of the MTHFR 677 C→T polymorphism and coronary heart disease in Europe, North America, or Australia, and stratification by geographical region and meta-regression by difference in mean serum homocysteine concentrations explored.