A
Ali Amin Al Olama
Researcher at University of Cambridge
Publications - 88
Citations - 8395
Ali Amin Al Olama is an academic researcher from University of Cambridge. The author has contributed to research in topics: Prostate cancer & Genome-wide association study. The author has an hindex of 41, co-authored 87 publications receiving 7276 citations.
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Journal ArticleDOI
Multiple newly identified loci associated with prostate cancer susceptibility.
Rosalind A. Eeles,Rosalind A. Eeles,Zsofia Kote-Jarai,Graham G. Giles,Graham G. Giles,Ali Amin Al Olama,Michelle Guy,Sarah Jugurnauth,Shani Mulholland,Daniel Leongamornlert,Stephen M. Edwards,Jonathan J. Morrison,Helen I. Field,Melissa C. Southey,Gianluca Severi,Gianluca Severi,Jenny L Donovan,Freddie C. Hamdy,David P. Dearnaley,David P. Dearnaley,Kenneth Muir,Charmaine Smith,Melisa Bagnato,Audrey Ardern-Jones,Amanda L. Hall,Amanda L. Hall,Lynne T. O'Brien,Beatrice N. Gehr-Swain,Beatrice N. Gehr-Swain,Rosemary A. Wilkinson,Cox A,Sarah J Lewis,Paul M. Brown,Sameer Jhavar,Malgorzata Tymrakiewicz,Artitaya Lophatananon,Sarah L Bryant,Alan Horwich,Alan Horwich,Robert Huddart,Robert Huddart,Vincent Khoo,Vincent Khoo,Chris Parker,Chris Parker,C. R. J. Woodhouse,Alan Thompson,Tim Christmas,Chris Ogden,Cyril Fisher,Charles Jamieson,Colin Cooper,Dallas R. English,John L. Hopper,David E. Neal,Douglas F. Easton +55 more
TL;DR: A genome-wide association study using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at ≤60 years or with a family history of disease, and 1,894 population-screened controls with a low prostate-specific antigen (PSA) concentration (<0.5 ng/ml) identified seven loci associated with prostate cancer on chromosomes 3, 6, 7, 10, 11, 19 and X.
Journal ArticleDOI
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
Fredrick R. Schumacher,Ali Amin Al Olama,Sonja I. Berndt,Sara Benlloch,Mahbubl Ahmed,Edward J. Saunders,Tokhir Dadaev,Daniel Leongamornlert,Ezequiel Anokian,Clara Cieza-Borrella,Chee Goh,Mark N. Brook,Xin Sheng,Laura Fachal,Joe Dennis,Jonathan Tyrer,Kenneth Muir,Kenneth Muir,Artitaya Lophatananon,Artitaya Lophatananon,Victoria L. Stevens,Susan M. Gapstur,Brian D. Carter,Catherine M. Tangen,Phyllis J. Goodman,Ian M. Thompson,Jyotsna Batra,Jyotsna Batra,Suzanne K. Chambers,Suzanne K. Chambers,Leire Moya,Leire Moya,Judith A. Clements,Judith A. Clements,Lisa G. Horvath,Wayne D. Tilley,Gail P. Risbridger,Gail P. Risbridger,Henrik Grönberg,Markus Aly,Tobias Nordström,Paul D.P. Pharoah,Nora Pashayan,Johanna Schleutker,Teuvo L.J. Tammela,Csilla Sipeky,Anssi Auvinen,Demetrius Albanes,Stephanie J. Weinstein,Alicja Wolk,Alicja Wolk,Niclas Håkansson,Catharine M L West,Alison M. Dunning,Neil G. Burnet,Lorelei A. Mucci,Edward Giovannucci,Gerald L. Andriole,Olivier Cussenot,Geraldine Cancel-Tassin,Stella Koutros,Laura E. Beane Freeman,Karina Dalsgaard Sørensen,Torben F. Ørntoft,Michael Borre,Lovise Maehle,Eli Marie Grindedal,David E. Neal,David E. Neal,David E. Neal,Jenny L Donovan,Freddie C. Hamdy,Richard M. Martin,Ruth C. Travis,Timothy J. Key,Robert J. Hamilton,Neil E. Fleshner,Antonio Finelli,Sue A. Ingles,Mariana C. Stern,Barry S. Rosenstein,Sarah L. Kerns,Harry Ostrer,Yong-Jie Lu,Hongwei Zhang,Ninghan Feng,Xueying Mao,Xin Guo,Guomin Wang,Zan Sun,Graham G. Giles,Melissa C. Southey,Robert J. MacInnis,Robert J. MacInnis,Liesel M. FitzGerald,Liesel M. FitzGerald,Adam S. Kibel,Bettina F. Drake,Ana Vega,Antonio Gómez-Caamaño,Robert Szulkin,Martin Eklund,Manolis Kogevinas,Javier Llorca,Gemma Castaño-Vinyals,Kathryn L. Penney,Meir J. Stampfer,Jong Y. Park,Thomas A. Sellers,Hui Yi Lin,Janet L. Stanford,Janet L. Stanford,Cezary Cybulski,Dominika Wokołorczyk,Jan Lubinski,Elaine A. Ostrander,Milan S. Geybels,Børge G. Nordestgaard,Sune F. Nielsen,Maren Weischer,Rasmus Bisbjerg,Martin Andreas Røder,Peter Iversen,Hermann Brenner,Katarina Cuk,Bernd Holleczek,Christiane Maier,Manuel Luedeke,Thomas J. Schnoeller,Jeri Kim,Christopher J. Logothetis,Esther M. John,Esther M. John,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Marta Cardoso,Susan L. Neuhausen,Linda Steele,Yuan Chun Ding,Kim De Ruyck,Gert De Meerleer,Piet Ost,Azad Hassan Abdul Razack,Jasmine Lim,Soo Hwang Teo,Daniel W. Lin,Daniel W. Lin,Lisa F. Newcomb,Lisa F. Newcomb,Davor Lessel,Marija Gamulin,Tomislav Kuliš,Radka Kaneva,Nawaid Usmani,Nawaid Usmani,Sandeep Singhal,Sandeep Singhal,Chavdar Slavov,Vanio Mitev,Matthew Parliament,Matthew Parliament,Frank Claessens,Steven Joniau,Thomas Van den Broeck,Samantha E.T. Larkin,Paul A. Townsend,Claire Aukim-Hastie,Manuela Gago Dominguez,Jose Esteban Castelao,Maria Elena Martinez,Monique J. Roobol,Guido Jenster,Ron H.N. van Schaik,Florence Menegaux,Thérèse Truong,Yves Akoli Koudou,Jianfeng Xu,Kay-Tee Khaw,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hardev Pandha,Agnieszka Michael,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Sara Lindström,Constance Turman,Jing Ma,David J. Hunter,Elio Riboli,A. Siddiq,Federico Canzian,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Zuxi Cui,Peter Kraft,Christopher I. Amos,David V. Conti,Douglas F. Easton,Fredrik Wiklund,Stephen J. Chanock,Brian E. Henderson,Zsofia Kote-Jarai,Christopher A. Haiman,Rosalind A. Eeles +207 more
TL;DR: A large meta-analysis combining genome-wide and custom high-density genotyping array data identifies 63 new susceptibility loci for prostate cancer, enhancing fine-mapping efforts and providing insights into the underlying biology of PrCa1.
Journal ArticleDOI
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array
Rosalind A. Eeles,Ali Amin Al Olama,Sara Benlloch,Edward J. Saunders,Daniel Leongamornlert,Malgorzata Tymrakiewicz,Maya Ghoussaini,Craig Luccarini,Joe Dennis,S Jugurnauth-Little,Tokhir Dadaev,David E. Neal,David E. Neal,Freddie C. Hamdy,Jenny L Donovan,Kenneth Muir,Kenneth Muir,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Fredrik Wiklund,Henrik Grönberg,Christopher A. Haiman,Fredrick R. Schumacher,Brian E. Henderson,Loic Le Marchand,Sara Lindström,Peter Kraft,David J. Hunter,Susan M. Gapstur,Stephen J. Chanock,Sonja I. Berndt,Demetrius Albanes,Gerald L. Andriole,Johanna Schleutker,Maren Weischer,Federico Canzian,Elio Riboli,Timothy J. Key,Ruth C. Travis,Daniele Campa,Sue A. Ingles,Esther M. John,Esther M. John,Richard B. Hayes,Paul D.P. Pharoah,Nora Pashayan,Kay-Tee Khaw,Janet L. Stanford,Janet L. Stanford,Elaine A. Ostrander,Lisa B. Signorello,Stephen N. Thibodeau,D J Schaid,Christiane Maier,Walther Vogel,Adam S. Kibel,Cezary Cybulski,Jan Lubinski,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Hermann Brenner,Jong Y. Park,Radka Kaneva,Jyotsna Batra,Amanda B. Spurdle,Judith A. Clements,Manuel R. Teixeira,Manuel R. Teixeira,Ed Dicks,Andy C. H. Lee,Alison M. Dunning,Caroline Baynes,Don M. Conroy,Melanie Maranian,Shahana Ahmed,Koveela Govindasami,Michelle Guy,Rosemary A. Wilkinson,Emma J. Sawyer,Angela Morgan,David P. Dearnaley,Alan Horwich,Robert Huddart,Vincent Khoo,Chris Parker,Nicholas van As,C. R. J. Woodhouse,Alan Thompson,Tim Dudderidge,Chris Ogden,Colin Cooper,Artitaya Lophatananon,Angela Cox,Melissa C. Southey,John L. Hopper,Dallas R. English,Dallas R. English,Markus Aly,Jan Adolfsson,Jiangfeng Xu,Siqun L. Zheng,Meredith Yeager,Rudolf Kaaks,W. Ryan Diver,Mia M. Gaudet,Mariana C. Stern,Roman Corral,Amit Joshi,Ahva Shahabi,Tiina Wahlfors,Teuvo L.J. Tammela,Anssi Auvinen,Jarmo Virtamo,Peter Klarskov,Børge G. Nordestgaard,M. Andreas Røder,Sune F. Nielsen,Stig E. Bojesen,Stig E. Bojesen,Afshan Siddiq,Liesel M. FitzGerald,Suzanne Kolb,Erika M. Kwon,Danielle M. Karyadi,William J. Blot,Wei Zheng,Qiuyin Cai,Shannon K. McDonnell,Antje E. Rinckleb,Bettina F. Drake,Graham A. Colditz,Dominika Wokołorczyk,Robert A. Stephenson,Robert A. Stephenson,Craig C. Teerlink,Heiko Müller,Dietrich Rothenbacher,Thomas A. Sellers,Hui-Yi Lin,C. Slavov,Vanio Mitev,Felicity Lose,Srilakshmi Srinivasan,Sofia Maia,Sofia Maia,Paula Paulo,Paula Paulo,Ethan M. Lange,Kathleen A. Cooney,Antonis C. Antoniou,Daniel Vincent,Francois Bacot,Daniel C. Tessier,Zsofia Kote-Jarai,Douglas F. Easton +156 more
TL;DR: In this paper, a custom Illumina array (iCOGS) was used to genotype 211,155 SNPs in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium.
Journal ArticleDOI
A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer
Ali Amin Al Olama,Zsofia Kote-Jarai,Sonja I. Berndt,David V. Conti,Fredrick R. Schumacher,Ying Han,Sara Benlloch,Dennis J. Hazelett,Zhaoming Wang,Ed Saunders,Daniel Leongamornlert,Sara Lindström,Sara Jugurnauth-Little,Tokhir Dadaev,Malgorzata Tymrakiewicz,Daniel O. Stram,Kristin A. Rand,Peggy Wan,Alex Stram,Xin Sheng,Loreall Pooler,Karen Park,Lucy Xia,Jonathan Tyrer,Laurence N. Kolonel,Loic Le Marchand,Robert N. Hoover,Mitchell J. Machiela,Merideth Yeager,Laurie Burdette,Charles C. Chung,Amy K. Hutchinson,Kai Yu,Chee Goh,Mahbubl Ahmed,Koveela Govindasami,Michelle Guy,Teuvo L.J. Tammela,Anssi Auvinen,Tiina Wahlfors,Johanna Schleutker,Tapio Visakorpi,Katri A. Leinonen,Jianfeng Xu,Markus Aly,Jenny L Donovan,Ruth C. Travis,Timothy J. Key,Afshan Siddiq,Federico Canzian,Kay-Tee Khaw,Atsushi Takahashi,Michiaki Kubo,Paul D.P. Pharoah,Nora Pashayan,Maren Weischer,Børge G. Nordestgaard,Sune F. Nielsen,Peter Klarskov,Martin Andreas Røder,Peter Iversen,Stephen N. Thibodeau,Shannon K. McDonnell,Daniel J. Schaid,Janet L. Stanford,Janet L. Stanford,Suzanne Kolb,Sarah K. Holt,Beatrice S. Knudsen,Antonio Hurtado Coll,Susan M. Gapstur,W. Ryan Diver,Victoria L. Stevens,Christiane Maier,Manuel Luedeke,Kathleen Herkommer,Antje E. Rinckleb,Sara S. Strom,Curtis A. Pettaway,Edward D. Yeboah,Edward D. Yeboah,Yao Tettey,Yao Tettey,Richard B. Biritwum,Richard B. Biritwum,Andrew A. Adjei,Andrew A. Adjei,Evelyn Tay,Evelyn Tay,Ann Truelove,Shelley Niwa,Anand P. Chokkalingam,Lisa A. Cannon-Albright,Lisa A. Cannon-Albright,Cezary Cybulski,Dominika Wokołorczyk,Wojciech Kluźniak,Jong Y. Park,Thomas A. Sellers,Hui-Yi Lin,William B. Isaacs,Alan W. Partin,Hermann Brenner,Aida Karina Dieffenbach,Christa Stegmaier,Constance Chen,Edward Giovannucci,Jing Ma,Meir J. Stampfer,Kathryn L. Penney,Lorelei A. Mucci,Esther M. John,Esther M. John,Sue A. Ingles,Rick A. Kittles,Adam B. Murphy,Hardev Pandha,Agnieszka Michael,Andrzej M. Kierzek,William J. Blot,Lisa B. Signorello,Wei Zheng,Demetrius Albanes,Jarmo Virtamo,Stephanie J. Weinstein,Barbara Nemesure,John D. Carpten,Cristina Leske,Suh-Yuh Wu,Anselm Hennis,Anselm Hennis,Adam S. Kibel,Benjamin A. Rybicki,Christine Neslund-Dudas,Ann W. Hsing,Ann W. Hsing,Lisa Chu,Lisa Chu,Phyllis J. Goodman,Eric A. Klein,S. Lilly Zheng,Jyotsna Batra,Judith A. Clements,Amanda B. Spurdle,Manuel R. Teixeira,Manuel R. Teixeira,Paula Paulo,Sofia Maia,Chavdar Slavov,Radka Kaneva,Vanio Mitev,John S. Witte,Graham Casey,Elizabeth M. Gillanders,Daniella Seminara,Elio Riboli,Freddie C. Hamdy,Gerhard A. Coetzee,Qiyuan Li,Matthew L. Freedman,David J. Hunter,Kenneth Muir,Kenneth Muir,Henrik Grönberg,David E. Neal,David E. Neal,Melissa C. Southey,Graham G. Giles,Graham G. Giles,Gianluca Severi,Gianluca Severi,Michael B. Cook,Hidewaki Nakagawa,Fredrik Wiklund,Peter Kraft,Stephen J. Chanock,Brian E. Henderson,Douglas F. Easton,Rosalind A. Eeles,Christopher A. Haiman +179 more
TL;DR: These findings provide new regions for investigation into the pathogenesis of prostate cancer and demonstrate the usefulness of combining ancestrally diverse populations to discover risk loci for disease.
Journal Article
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study
Rosalind A. Eeles,Zsofia Kote-Jarai,Ali Amin Al Olama,Graham G. Giles,Michelle Guy,Gianluca Severi,Kenneth Muir,John L. Hopper,Brian E. Henderson,Christopher A. Haiman,and other,Judith A. Clements,Jyotsna Batra,Mary-Anne Kedda,Felicity Lose,Kimberly Alexander +15 more
TL;DR: In this article, the authors conducted a genome-wide association study in which 541,129 SNPs were genotyped in 1,854 prostate cancer cases with clinically detected disease and 1,894 controls.