Satoru Yonekura

TL;DR: Profiling of gut microbiota demonstrated a significantly higher abundance of Bacteroides intestinalis in patients with toxicity, with upregulation of mucosal IL-1b in patient samples of colitis and in pre-clinical models, which offer potential new therapeutic angles for targeting toxicity to CICB.

TL;DR: It is demonstrated that immunogenic ileal apoptosis contributes to the prognosis of chemotherapy-treated CC, and local microbiome composition influences treatment efficacy of chemotherapy in colon cancer via modulation of tolerogenic versus immunogenic IECs and the accumulation of T FH cells in patients with CC and mice.

TL;DR: This is the first report to show that HIF inhibitor treatment suppresses NOTCH1 signalling, and HIF inhibitors could be novel candidates for a molecular-targeted therapy against leukaemia.

TL;DR: The use of AB before ICIs treatment was a predictor of poor ICIs response in metastatic RCC and was independent prognostic factors for PFS in association with ICIs therapy.

TL;DR: This dynamic ménage-à-trois offers novel coordinated actors of the humoral and cellular immune responses actionable to restore sensitivity to immune checkpoint inhibition and results in the elicitation of a productive Tfh and B cell dialogue in mesenteric lymph nodes culminating in tumor-specific memory T cell responses sparing the normal epithelium.