S
Sean P. J. Whelan
Researcher at Washington University in St. Louis
Publications - 194
Citations - 22049
Sean P. J. Whelan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Vesicular stomatitis virus & Virus. The author has an hindex of 58, co-authored 171 publications receiving 15387 citations. Previous affiliations of Sean P. J. Whelan include University of Pittsburgh & University of Alabama.
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The ancient fusogen EnvP(b)1 is expressed in human tissues and its structure informs the evolution of gammaretrovirus envelope proteins
Kevin R. McCarthy,Kevin R. McCarthy,Joseph L. Timpona,Joseph L. Timpona,Simon Jenni,Vesna Brusic,Welkin E. Johnson,Sean P. J. Whelan,Sean P. J. Whelan,Lindsey R. Robinson-McCarthy +9 more
TL;DR: A common conserved architecture that underlies the varied receptor binding activity of divergent Env genes is found, and the modularity and versatility of this domain may underpin the evolutionary success of this clade of fusogens.
Book ChapterDOI
Biochemical and Structural Insights into Vesicular Stomatitis Virus Transcription
Amal A. Rahmeh,Sean P. J. Whelan +1 more
Posted ContentDOI
Vesicular stomatitis virus transcription is inhibited by TRIM69 in the interferon-induced antiviral state
Tonya Kueck,Louis Marie Bloyet,Elena Cassella,Trinity Zang,Trinity Zang,Fabian Schmidt,Vesna Brusic,Gergely Tekes,Owen Pornillos,Sean P. J. Whelan,Paul D. Bieniasz,Paul D. Bieniasz +11 more
TL;DR: A loss-of-function screen to identify genes required for the activity of IFNα against vesicular stomatitis virus, Indiana serotype (VSVIND), a prototype negative strand RNA virus revealed that TRIM69, a member of tripartite motif family of proteins, is a VSVIND inhibitor.
Posted ContentDOI
Messenger RNA cap methylation by PCIF1 attenuates the interferon-β induced antiviral state
Michael A Tartell,Michael A Tartell,Konstantinos Boulias,Konstantinos Boulias,Gabriela Brunsting Hoffmann,Eric L. Greer,Eric L. Greer,Sean P. J. Whelan +7 more
TL;DR: A role for the host cell N6-adenosine mRNA cap-methylase, phosphorylated C-terminal domain interacting factor 1 (PCIF1), in attenuating the antiviral activity of interferon-β is reported, suggesting this contributes to viral evasion of innate immune suppression.