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Sean P. J. Whelan
Researcher at Washington University in St. Louis
Publications - 194
Citations - 22049
Sean P. J. Whelan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Vesicular stomatitis virus & Virus. The author has an hindex of 58, co-authored 171 publications receiving 15387 citations. Previous affiliations of Sean P. J. Whelan include University of Pittsburgh & University of Alabama.
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Attenuated nonsegmented negative-sense RNA viruses with reduced mRNA cap methyltransferase activity comprising mutations within conserved domain VI of the large polymerase
Sean P. J. Whelan,Jianrong Li +1 more
TL;DR: In this paper, an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene was described, and the methods of manufacturing and methods of use were described.
Posted ContentDOI
Lymphocytic choriomeningitis arenavirus utilises tunnelling nanotube-like intercellular connections for cell-to-cell spread
Amelia Shaw,Hiu Nam Tse,Alex Moon-Walker,Erica Ollmann Saphire,Sean P. J. Whelan,Martin Stacey,Roger Hewson,Juan Fontana,John N. Barr +8 more
TL;DR: In this article , the authors used recombinant LCMV with engineered epitope tags in glycoprotein spike (GP-1) and matrix (Z) proteins, alongside nucleoprotein (NP) antisera, to reveal that all three major structural proteins co-localized within TNT-like connections.
Journal ArticleDOI
Factor Xa cleaves SARS-CoV-2 spike protein to block viral entry and infection
Wenjuan Dong,Jing Wang,L. Tian,Jianying Zhang,Erik W. Settles,Chao Qin,Ashley N. Itogawa,Kimberly R. Celona,Jinhee Yi,Mitchell L. Bryant,Heather L. Mead,Sierra A. Jaramillo,Hongjia Lu,Aimin Li,Ross E. Zumwalt,Sanjeet Dadwal,Pinghui Feng,Weiming Yuan,Sean P. J. Whelan,Paul Keim,Bridget M. Barker,Michael A. Caligiuri,Jianhua Yu +22 more
TL;DR: In this paper , the authors showed that factor (F) Xa, an SP involved in blood coagulation, is upregulated in COVID-19 patients and showed that FXa exerts antiviral activity.
Journal ArticleDOI
BSL2-compliant lethal mouse model of SARS-CoV-2 and variants of concern to evaluate therapeutics targeting the Spike protein
Mohanraj Manangeeswaran,Derek D. C. Ireland,Seth G. Thacker,Ha-Na Lee,Logan Kelley-Baker,Aaron P. Lewkowicz,Paul W. Rothlauf,Marjorie Cornejo Pontelli,Louis-Marie Bloyet,Michael Eckhaus,Mirian Mendoza,Sean P. J. Whelan,Daniela Verthelyi +12 more
TL;DR: It is proposed that rVSV-SARS2-S virus can be used to understand the effect of changes to SARS-CoV-2 spike protein on infection and to evaluate existing or experimental therapeutics targeting spike protein of current or future VOC of Sars-Cov-2 under BSL-2 conditions.
Journal ArticleDOI
A simple point-of-care assay accurately detects anti-spike antibodies after SARS-CoV-2 vaccination
Sarah E. Greene,Yue-qing Huang,Wooseob Kim,Mariel J. Liebeskind,Vinay D. Chandrasekaran,Zhuoming Li,Parakkal Deepak,Michael A. Paley,Daphne Lew,Monica Yang,Mehrdad Matloubian,Lianne S. Gensler,Mary C. Nakamura,Jane A. O'Hallaran,Rachel M. Presti,Sean P. J. Whelan,William Buchser,Alfred H.J. Kim,Gary J. Weil +18 more
TL;DR: In this paper , the authors compared results obtained with the COVIBLOCK Covid-19 LFA to those obtained by anti-spike (S) ELISA, and found that LFA scores were statistically significantly lower in samples from immunosuppressed participants, and were significantly correlated with anti-S antibody levels measured by ELISA.