Sean P. J. Whelan

TL;DR: In this article, a method for recovering wildtype or engineered negative stranded, non-segmented RNA virus genomes containing non-coding 3' and 5' regions (e.g., leader or trailer regions) surrounding one, several or all of the genes of the virus or one or more heterologous gene(s) in the form of ribonucleocapsids containing N, P and L proteins, which are capable of replicating and assembling with the remaining structural proteins to bud and form virions, or which are only capable of infecting one cell,

TL;DR: The results suggest that hepatocyte survival and maintenance of function in sepsis is dependent on a mitochondrial homeostasis pathway marked by mitophagy and biogenesis, and CLP‐induced markers of mitochondrial biogenesis and mitochondrial number and density recovered over time.

TL;DR: In vivo and pathological relevance of TcdA–sGAGs interactions are demonstrated, and a potential therapeutic approach of protecting colonic tissues by blocking these interactions is revealed.

TL;DR: It is demonstrated that a gene-end sequence must be positioned a minimal distance from a gene -start sequence for the polymerase to efficiently terminate transcription, and that the sequence between the gene-start and gene- end signals, or its potential to adopt an RNA secondary structure, had only a minor effect on the efficiency with which polymerase terminated transcription.

TL;DR: In this paper, a panel of neutralizing anti-SARS-CoV-2 monoclonal antibodies (mAbs) that bound the receptor binding domain of the spike protein at distinct epitopes and blocked virus attachment to its host receptor, human angiotensin converting enzyme-2 (hACE2).