Sean P. J. Whelan

TL;DR: Optimization by improving potency, reducing hydrophobicity, and replacing labile moieties identified 3.47 derivatives with improved in vitro ADME properties that are also highly active against EBOV infection, including when tested in the presence of 50% normal human serum (NHS).

TL;DR: In this article, a method for recovering wildtype or engineered negative stranded, non-segmented RNA virus genomes containing non-coding 3' and 5' regions (e.g., leader or trailer regions) surrounding one, several or all of the genes of the virus or one or more heterologous gene(s) in the form of ribonucleocapsids containing N, P and L proteins, which are capable of replicating and assembling with the remaining structural proteins to bud and form virions, or which are only capable of infecting one cell,

TL;DR: The envelope protein (ENV) of the virus is characterized to define how it mediates infection of cells and provides new insights into the entry pathway of an extinct human virus and provides a powerful tool to further probe the endocytic route by which HERV-K infects cells.

TL;DR: This work reconstructs and defines key steps in the infectious entry pathway of an extinct virus as well as identifying 11 genes involved in heparan sulfate biosynthesis.

TL;DR: In this paper, the authors used cell-based and in vitro biochemical assays to demonstrate that PCIF1 efficiently modifies vesicular stomatitis virus mRNA cap structures to m7Gpppm6Am and define the substrate requirements for this modification.