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Sean P. J. Whelan
Researcher at Washington University in St. Louis
Publications - 194
Citations - 22049
Sean P. J. Whelan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Vesicular stomatitis virus & Virus. The author has an hindex of 58, co-authored 171 publications receiving 15387 citations. Previous affiliations of Sean P. J. Whelan include University of Pittsburgh & University of Alabama.
Papers
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Structure of a rabies virus polymerase complex from electron cryo-microscopy
Joshua A. Horwitz,Simon Jenni,Stephen C. Harrison,Stephen C. Harrison,Sean P. J. Whelan,Sean P. J. Whelan +5 more
TL;DR: A complete structure of RABV L bound with its phosphoprotein cofactor (P) is described, determined by electron cryo-microscopy at 3.3 Å resolution, which suggests distinct template and product entry and exit pathways during transcription and replication.
Journal ArticleDOI
Visualizing molecular interactions that determine assembly of a bullet-shaped vesicular stomatitis virus particle
TL;DR: In this paper , the structure of intact, infectious VSV particles determined by cryogenic electron microscopy was reconstructed at 3.5 Å resolution, with lower resolution for the rounded tip.
Patent
Attenuated vaccines for non-segmented negative sense rna viruses
Sean P. J. Whelan,Jianrong Li +1 more
TL;DR: In this article, an attenuated non-segmented negative-sense RNA virus characterized by at least one mutation in the L gene was described, and the methods of manufacturing and methods of use were described.
Journal ArticleDOI
Rethinking the Response to Emerging Microbes: Vaccines and Therapeutics in the Ebola Era—a Conference at Harvard Medical School
David M. Knipe,Sean P. J. Whelan +1 more
TL;DR: The meeting led to a call for improved basic medical care for all and continued support of basic discovery research to provide the foundation for preparedness for future outbreaks.
Journal ArticleDOI
Defective Interfering Particles of Vesicular Stomatitis Virus: Functions of the Genomic Termini☆
Sean P. J. Whelan,Gail W. Wertz +1 more
TL;DR: Findings explain why the majority of DI RNAs are of the 5′ copy-back class: RNAs with complementary termini from either end have a replicative advantage, but only 5′copy-back RNAs contain the signal for assembly into particles.