S
Sean P. J. Whelan
Researcher at Washington University in St. Louis
Publications - 194
Citations - 22049
Sean P. J. Whelan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Vesicular stomatitis virus & Virus. The author has an hindex of 58, co-authored 171 publications receiving 15387 citations. Previous affiliations of Sean P. J. Whelan include University of Pittsburgh & University of Alabama.
Papers
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Journal ArticleDOI
A vaccine-induced public antibody protects against SARS-CoV-2 and emerging variants.
Aaron J. Schmitz,Jackson S. Turner,Zhuoming Liu,Julian Q. Zhou,Ishmael D. Aziati,Rita E. Chen,Astha Joshi,Traci L. Bricker,Tamarand L. Darling,Daniel C. Adelsberg,Clara G. Altomare,Wafaa B. Alsoussi,James Brett Case,Laura A. VanBlargan,Tingting Lei,Mahima Thapa,Fatima Amanat,Trushar Jeevan,Thomas P. Fabrizio,Jane A. O’Halloran,Pei Yong Shi,Rachel M. Presti,Richard J. Webby,Florian Krammer,Sean P. J. Whelan,Goran Bajic,Michael S. Diamond,Adrianus C. M. Boon,Ali H. Ellebedy +28 more
TL;DR: In this paper, the authors analyzed receptor binding domain-binding monoclonal antibodies derived from SARS-CoV-2 mRNA vaccine-elicited germinal center B cells for neutralizing activity against the WA1/2020 D614G SARS CoV2 strain and variants of concern.
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A New Transferrin Receptor Aptamer Inhibits New World Hemorrhagic Fever Mammarenavirus Entry
Keith E. Maier,Rohit K. Jangra,Kevin Shieh,David K. Cureton,Hui Xiao,Erik L. Snapp,Sean P. J. Whelan,Kartik Chandran,Matthew Levy +8 more
TL;DR: Competitive in vitro selections against hTfR-expressing cells with supplemented Tf enhance both aptamer binding and the potency of viral inhibition and highlight the ability to use a competitor to bias the outcome of a selection.
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Structure of the Vesicular Stomatitis Virus L Protein in Complex with Its Phosphoprotein Cofactor
Simon Jenni,Louis Marie Bloyet,Ruben Diaz-Avalos,Bo Liang,Sean P. J. Whelan,Sean P. J. Whelan,Nikolaus Grigorieff,Nikolaus Grigorieff,Stephen C. Harrison,Stephen C. Harrison +9 more
TL;DR: The model shows that a conserved tryptophan in the priming loop can support the initiating 5′ nucleotide and contacts of three P segments with multiple L domains show how P induces a closed, compact, initiationcompetent conformation.
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Vesicular Stomatitis Virus mRNA Capping Machinery Requires Specific cis-Acting Signals in the RNA
TL;DR: Working with vesicular stomatitis virus (VSV), a prototype of the NNS RNA viruses, it is shown that mRNA cap formation is further distinct, requiring a specific cis-acting signal in the RNA.
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Genetic Inactivation of COPI Coatomer Separately Inhibits Vesicular Stomatitis Virus Entry and Gene Expression
TL;DR: It is found that disrupting COPI function by RNAi inhibited an early stage of vesicular stomatitis virus (VSV) replication, offering an explanation of why COPI coatomer is frequently identified in screens for cellular factors that support cell invasion by microbial pathogens.