S
Sean P. J. Whelan
Researcher at Washington University in St. Louis
Publications - 194
Citations - 22049
Sean P. J. Whelan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Vesicular stomatitis virus & Virus. The author has an hindex of 58, co-authored 171 publications receiving 15387 citations. Previous affiliations of Sean P. J. Whelan include University of Pittsburgh & University of Alabama.
Papers
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Journal ArticleDOI
Subcapsular sinus macrophages prevent CNS invasion on peripheral infection with a neurotropic virus
Matteo Iannacone,E. Ashley Moseman,Elena Tonti,Lidia Bosurgi,Tobias Junt,Sarah E. Henrickson,Sean P. J. Whelan,Luca G. Guidotti,Ulrich H. von Andrian +8 more
TL;DR: It is shown that SCS macrophages perform a third vital function: they prevent lymph-borne neurotropic viruses from infecting the central nervous system (CNS) on peripheral infection with vesicular stomatitis virus.
Journal ArticleDOI
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape.
Tyler N. Starr,Nadine Czudnochowski,Zhuoming Liu,Fabrizia Zatta,Young-Jun Park,Amin Addetia,Dora Pinto,Martina Beltramello,Patrick Hernandez,Allison J. Greaney,Allison J. Greaney,Roberta Marzi,William G. Glass,Ivy Zhang,Ivy Zhang,Adam S. Dingens,John E. Bowen,M. Alejandra Tortorici,Alexandra C. Walls,Jason A. Wojcechowskyj,Anna De Marco,Laura E. Rosen,Jiayi Zhou,Martin Montiel-Ruiz,Hannah Kaiser,Josh Dillen,Heather Tucker,Jessica Bassi,Chiara Silacci-Fregni,Michael P. Housley,Julia di Iulio,Gloria Lombardo,Maria L. Agostini,Nicole Sprugasci,Katja Culap,Stefano Jaconi,Marcel Meury,Exequiel Dellota,Rana Abdelnabi,Shi-Yan Caroline Foo,Elisabetta Cameroni,Spencer Stumpf,Tristan I. Croll,Jay C. Nix,Colin Havenar-Daughton,Luca Piccoli,Fabio Benigni,Johan Neyts,Amalio Telenti,Florian A. Lempp,Matteo Samuele Pizzuto,John D. Chodera,Christy M. Hebner,Herbert W. Virgin,Herbert W. Virgin,Sean P. J. Whelan,David Veesler,Davide Corti,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom,Gyorgy Snell +61 more
TL;DR: In this paper, the authors comprehensively characterize escape, breadth and potency across a panel of SARS-CoV-2 antibodies targeting the receptor-binding domain (RBD).
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Deciphering the glycosylome of dystroglycanopathies using haploid screens for lassa virus entry.
Lucas T. Jae,Matthijs Raaben,Moniek Riemersma,Ellen van Beusekom,Vincent A. Blomen,Arno Velds,Ron M. Kerkhoven,Jan E. Carette,Haluk Topaloglu,Peter Meinecke,Marja W. Wessels,Dirk Lefeber,Sean P. J. Whelan,Hans van Bokhoven,Thijn R. Brummelkamp,Thijn R. Brummelkamp +15 more
TL;DR: Comprehensive forward genetic screens can be used to define the genetic architecture of a complex disease and point out genes defective in dystroglycanopathies.
Journal ArticleDOI
Effect of Immunosuppression on the Immunogenicity of mRNA Vaccines to SARS-CoV-2 : A Prospective Cohort Study.
Parakkal Deepak,Wooseob Kim,Michael A. Paley,Monica Yang,Alexander Carvidi,Emanuel G Demissie,Alia A El-Qunni,Alem Haile,Katherine Huang,Baylee Kinnett,Mariel J. Liebeskind,Zhuoming Liu,Lily E McMorrow,Diana Paez,Niti Pawar,Dana C. Perantie,Rebecca E Schriefer,Shannon E Sides,Mahima Thapa,Maté Gergely,Suha Abushamma,Sewuese E. Akuse,Michael K. Klebert,Lynne M. Mitchell,Darren Nix,Jonathan Graf,Kimberly E. Taylor,Salim Chahin,Matthew A. Ciorba,Patricia P. Katz,Mehrdad Matloubian,Jane A. O’Halloran,Rachel M. Presti,Gregory F. Wu,Sean P. J. Whelan,William Buchser,Lianne S. Gensler,Mary C. Nakamura,Ali H. Ellebedy,Alfred H.J. Kim +39 more
TL;DR: In this paper, the immunogenicity of mRNA-based SARS-CoV-2 vaccines in patients with chronic inflammatory disease (CID) was evaluated in an observational cohort study.
Journal ArticleDOI
Lassa virus entry requires a trigger-induced receptor switch
Lucas T. Jae,Matthijs Raaben,Andrew S. Herbert,Ana I. Kuehne,Ariel S. Wirchnianski,Timothy K. Soh,Sarah H. Stubbs,Hans Janssen,Markus Damme,Paul Saftig,Sean P. J. Whelan,John M. Dye,Thijn R. Brummelkamp,Thijn R. Brummelkamp +13 more
TL;DR: It is shown that to enter a cell, the virus requires a second receptor, this one inside the infected cell, which sheds light on the “enigmatic resistance” of bird cells to Lassa virus, and the resistance of Lamp1-deficient mice to Lasso virus highlights the relevance of this receptor switch in vivo.