S
Sean P. J. Whelan
Researcher at Washington University in St. Louis
Publications - 194
Citations - 22049
Sean P. J. Whelan is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Vesicular stomatitis virus & Virus. The author has an hindex of 58, co-authored 171 publications receiving 15387 citations. Previous affiliations of Sean P. J. Whelan include University of Pittsburgh & University of Alabama.
Papers
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Journal ArticleDOI
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition
Sara Cherry,Tammy Doukas,Susan Armknecht,Sean P. J. Whelan,Hui Wang,Peter Sarnow,Norbert Perrimon +6 more
TL;DR: Increased sensitivity to ribosome levels also holds true for poliovirus infection of human cells, demonstrating the generality of these findings.
Posted ContentDOI
Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition.
Allison J. Greaney,Allison J. Greaney,Tyler N. Starr,Pavlo Gilchuk,Seth J. Zost,Elad Binshtein,Andrea N. Loes,Andrea N. Loes,Sarah K Hilton,John Huddleston,Rachel Eguia,Katharine H.D. Crawford,Katharine H.D. Crawford,Adam S. Dingens,Rachel S. Nargi,Rachel E. Sutton,Naveenchandra Suryadevara,Paul W. Rothlauf,Paul W. Rothlauf,Zhuoming Liu,Sean P. J. Whelan,Robert H. Carnahan,James E. Crowe,Jesse D. Bloom,Jesse D. Bloom,Jesse D. Bloom +25 more
TL;DR: A deep mutational scanning method is described to map how all amino-acid mutations in the RBD affect antibody binding, and a complete escape-mutation maps enable rational design of antibody therapeutics and assessment of the antigenic consequences of viral evolution.
Book
A novel broad-spectrum antiviral targeting entry of enveloped viruses.
Michael Wolf,Alexander N. Freiberg,Tinghu Zhang,Zeynep Akyol-Ataman,Andrew Grock,Patrick Hong,Jianrong Li,Jianrong Li,Natalya F. Watson,Angela Q. Fang,Hector C. Aguilar,Matteo Porotto,Anna N. Honko,Robert Damoiseaux,John P. Miller,Sara E. Woodson,Steven Chantasirivisal,Vanessa Fontanes,Oscar A. Negrete,Paul Krogstad,Asim Dasgupta,Anne Moscona,Lisa E. Hensley,Sean P. J. Whelan,Kym F. Faull,Michael R. Holbrook,Michael E. Jung,Benhur Lee +27 more
TL;DR: A class of broad-spectrum antivirals effective against enveloped viruses that target the viral lipid membrane and compromises its ability to mediate virus–cell fusion are revealed.
Journal ArticleDOI
Structure of the L Protein of Vesicular Stomatitis Virus from Electron Cryomicroscopy.
Bo Liang,Zongli Li,Zongli Li,Simon Jenni,Amal A. Rahmeh,Benjamin Morin,Tim Grant,Nikolaus Grigorieff,Stephen C. Harrison,Stephen C. Harrison,Sean P. J. Whelan +10 more
TL;DR: The large (L) proteins of non-segmented, negative-strand RNA viruses, a group that includes Ebola and rabies viruses, catalyze RNA-dependent RNA polymerization with viral ribonucleoprotein as template, a non-canonical sequence of capping and methylation reactions, and polyadenylation of viral messages.
Journal ArticleDOI
An antiviral role for the RNA interference machinery in Caenorhabditis elegans
TL;DR: The observation that multiple genes required for RNAi are also required for resistance to vesicular stomatitis virus suggests that the RNAi machinery functions in resistance to viruses in nature.