S
Sebastian Damerow
Researcher at University of Dundee
Publications - 22
Citations - 1266
Sebastian Damerow is an academic researcher from University of Dundee. The author has contributed to research in topics: Fucosyltransferase & Trypanosoma brucei. The author has an hindex of 11, co-authored 21 publications receiving 1054 citations. Previous affiliations of Sebastian Damerow include Max Planck Society & Hannover Medical School.
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Journal ArticleDOI
The circadian rhythm of glucocorticoids is regulated by a gating mechanism residing in the adrenal cortical clock
Henrik Oster,Sebastian Damerow,Sebastian Damerow,Silke Kiessling,Vladimira Jakubcakova,Diya Abraham,Jiong Tian,Matthias W. Hoffmann,Gregor Eichele +8 more
TL;DR: In this paper, the clock gene expression was detected in the outer adrenal cortex prefiguring a role of the clock in regulating gluco-and mineral corticoid biogenesis.
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Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
Mahima Swamy,Shalini Pathak,Katarzyna M. Grzes,Sebastian Damerow,Linda V. Sinclair,Daan M. F. van Aalten,Doreen A. Cantrell +6 more
TL;DR: Notch, the T cell antigen receptor and c-Myc are identified as key controllers of T cell protein O-GlcNAcylation via regulation of glucose and glutamine transport, fundamental for T cell biology.
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Transcriptional Profiling in the Adrenal Gland Reveals Circadian Regulation of Hormone Biosynthesis Genes and Nucleosome Assembly Genes
TL;DR: The authors perform whole genome microarray hybridization to characterize the circadian transcriptome of the murine adrenal and identify classes of transcripts that may synchronize adrenal hormone production, suggesting a novel way by which the circadian clock may regulate the chromatin state.
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Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis
Beatriz Baragaña,Barbara Forte,Ryan Choi,Stephen N. Hewitt,Juan A. Bueren-Calabuig,João Pedro Pisco,Caroline Peet,David M. Dranow,David A. Robinson,Chimed Jansen,Neil R. Norcross,Sumiti Vinayak,Mark G. Anderson,Carrie F. Brooks,Caitlin A. Cooper,Sebastian Damerow,Michael J. Delves,Karen Dowers,James Duffy,Thomas E. Edwards,Irene Hallyburton,Benjamin G. Horst,Matthew A. Hulverson,Liam Ferguson,María Belén Jiménez-Díaz,Rajiv S. Jumani,Donald D. Lorimer,Melissa S. Love,Steven P. Maher,Holly Matthews,Case W. McNamara,Peter J. Miller,Sandra O’Neill,Kayode K. Ojo,Maria Osuna-Cabello,Erika G. Pinto,John Post,Jennifer Riley,Matthias Rottmann,Matthias Rottmann,Laura M. Sanz,Paul Scullion,Arvind Sharma,Sharon M. Shepherd,Yoko Shishikura,Frederick R. C. Simeons,Erin E. Stebbins,Laste Stojanovski,Ursula Straschil,Fábio K. Tamaki,Jevgenia Tamjar,Leah S. Torrie,Amélie Vantaux,Benoit Witkowski,Sergio Wittlin,Sergio Wittlin,Manickam Yogavel,Fabio Zuccotto,Iñigo Angulo-Barturen,Robert E. Sinden,Jake Baum,Francisco-Javier Gamo,Pascal Mäser,Pascal Mäser,Dennis E. Kyle,Elizabeth A. Winzeler,Peter J. Myler,Peter J. Myler,Paul G. Wyatt,David Floyd,David M. Matthews,Amit Sharma,Boris Striepen,Boris Striepen,Christopher D. Huston,David W. Gray,Alan H. Fairlamb,Andrei V. Pisliakov,Chris Walpole,Kevin D. Read,Wesley C. Van Voorhis,Ian H. Gilbert +81 more
TL;DR: This work validates apicomplexan KRSs as promising targets for the development of drugs for malaria and cryptosporidiosis and identifies an opportunity for pathogen hopping based on the structural homology between PfKRS1 and CpKRS.
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Leishmania UDP-sugar pyrophosphorylase:the missing link in galactose salvage?
Sebastian Damerow,Anne-Christin Lamerz,Thomas Haselhorst,Jana Führing,Patricia Zarnovican,Mark von Itzstein,Françoise H. Routier +6 more
TL;DR: The characterization of an L. major UDP-sugar pyrophosphorylase able to reversibly activate galactose 1-phosphate into UDP-galactose is presented thus proving the existence of the Isselbacher salvage pathway in this parasite.