Christopher D. Huston

TL;DR: Use of cryptosporidium genomes has helped to identify promising therapeutic targets, and drugs are in development, but methods to assess the efficacy in vitro and in animals are not well standardised.

TL;DR: From the International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh; the University of Vermont, Burlington (C.D.H., E.H.H, W.A.P.), and theUniversity of Virginia, Charlottesville, Charlottesville.

TL;DR: The results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications.

TL;DR: The Medicines for Malaria Venture Malaria Box as mentioned in this paper is a collection of over 400 compounds representing families of structures identified in phenotypic screens of pharmaceutical and academic libraries against the Plasmodium falciparum malaria parasite.

TL;DR: Rapid parasite‐induced activation of caspase 3‐like caspases, independent of the upstream caspased 8 and 9, which is required for host cell death is demonstrated.