S
Sébastien Boutet
Researcher at SLAC National Accelerator Laboratory
Publications - 221
Citations - 19765
Sébastien Boutet is an academic researcher from SLAC National Accelerator Laboratory. The author has contributed to research in topics: Femtosecond & Laser. The author has an hindex of 61, co-authored 207 publications receiving 17171 citations. Previous affiliations of Sébastien Boutet include Lawrence Livermore National Laboratory & Fermilab.
Papers
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Journal ArticleDOI
Ultra-precise characterization of LCLS hard X-ray focusing mirrors by high resolution slope measuring deflectometry.
Frank Siewert,Jana Buchheim,Sébastien Boutet,Garth J. Williams,Paul A. Montanez,Jacek Krzywinski,Riccardo Signorato +6 more
TL;DR: Tests confirmed that KB mirrors of 350mm aperture length characterized by an outstanding residual figure error of <1 nm rms has been realized and the clamping of the mirrors to be a critical step for the final - shape preserving installation of such outstanding optics.
Journal ArticleDOI
Cryptotomography: reconstructing 3D Fourier intensities from randomly oriented single-shot diffraction patterns.
N. D. Loh,Michael J. Bogan,Veit Elser,Anton Barty,Sébastien Boutet,Saša Bajt,Janos Hajdu,Tomas Ekeberg,Filipe R. N. C. Maia,Joachim Schulz,M. Marvin Seibert,Bianca Iwan,Nicusor Timneanu,Stefano Marchesini,Ilme Schlichting,Robert L. Shoeman,Lukas Lomb,Matthias Frank,Mengning Liang,Henry N. Chapman +19 more
TL;DR: This first experimental demonstration of cryptotomography extended the expansion-maximization-compression framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter to realize single-shot diffraction imaging of single biomolecules.
Journal ArticleDOI
A novel inert crystal delivery medium for serial femtosecond crystallography
Chelsie E. Conrad,Shibom Basu,Daniel James,Dingjie Wang,Alexander Schaffer,Shatabdi Roy-Chowdhury,Nadia A. Zatsepin,Andrew Aquila,Jesse Coe,Cornelius Gati,Mark S. Hunter,Jason E. Koglin,Christopher Kupitz,Garrett Nelson,Ganesh Subramanian,Thomas A. White,Yun Zhao,James Zook,Sébastien Boutet,Vadim Cherezov,John C. H. Spence,Raimund Fromme,Uwe Weierstall,Petra Fromme +23 more
TL;DR: Viscous sample delivery that decreases the net protein consumed in serial femtosecond crystallography is described, which has a low background, is compatible with membrane proteins and can be used at a wide range of temperatures.
Proceedings ArticleDOI
The CSPAD megapixel x-ray camera at LCLS
Philip Hart,Sébastien Boutet,Gabriella Carini,Mikhail Dubrovin,B. Duda,David Fritz,Gunther Haller,Ryan Herbst,Sven Herrmann,C.J. Kenney,Nadine Kurita,Henrik T. Lemke,Marc Messerschmidt,Martin Nordby,J. Pines,Don Schafer,Matt Swift,M. Weaver,Garth J. Williams,Diling Zhu,Niels van Bakel,John Morse +21 more
TL;DR: The Cornell-SLAC Pixel Array Detector (CSPAD) as mentioned in this paper is a camera system at the Linear Coherent Light Source (LCLS) that can image scattered x-rays on a per-shot basis.
Journal ArticleDOI
Macromolecular diffractive imaging using imperfect crystals
Kartik Ayyer,Oleksandr Yefanov,Dominik Oberthür,Shatabdi Roy-Chowdhury,Lorenzo Galli,Valerio Mariani,Shibom Basu,Jesse Coe,Chelsie E. Conrad,Raimund Fromme,Alexander Schaffer,Katerina Dörner,Daniel James,Christopher Kupitz,Christopher Kupitz,Markus Metz,Garrett Nelson,Paulraj Lourdu Xavier,Kenneth R. Beyerlein,Marius Schmidt,Iosifina Sarrou,John C. H. Spence,Uwe Weierstall,Thomas A. White,Jay How Yang,Yun Zhao,Mengning Liang,Andrew Aquila,Mark S. Hunter,Joseph Robinson,Jason E. Koglin,Sébastien Boutet,Petra Fromme,Anton Barty,Henry N. Chapman +34 more
TL;DR: This result shows that continuous diffraction can be used to overcome what have long been supposed to be the resolution limits of macromolecular crystallography, using a method that exploits commonly encountered imperfect crystals and enables model-free phasing.