S
Shailendra Mani
Researcher at Translational Health Science and Technology Institute
Publications - 46
Citations - 1305
Shailendra Mani is an academic researcher from Translational Health Science and Technology Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 9, co-authored 33 publications receiving 729 citations. Previous affiliations of Shailendra Mani include National University of Singapore & International Centre for Genetic Engineering and Biotechnology.
Papers
More filters
Journal ArticleDOI
Fatal swine acute diarrhoea syndrome caused by an HKU2-related coronavirus of bat origin.
Peng Zhou,Hang Fan,Tian Lan,Xing-Lou Yang,Weifeng Shi,Wei Zhang,Yan Zhu,Ya-Wei Zhang,Qingmei Xie,Shailendra Mani,Xiao-Shuang Zheng,Bei Li,Jinman Li,Hua Guo,Guangqian Pei,Xiaoping An,Jun-Wei Chen,Ling Zhou,Kai-jie Mai,Zixian Wu,Di Li,Danielle E. Anderson,Libiao Zhang,Shi-Yue Li,Zhiqiang Mi,Tongtong He,Feng Cong,Pengju Guo,Ren Huang,Yun Luo,Xiang-Ling Liu,Jing Chen,Yong Huang,Qiang Sun,Xianglilan Zhang,Yuan-Yuan Wang,Shaozhen Xing,Yan-Shan Chen,Yuan Sun,Juan Li,Peter Daszak,Lin-Fa Wang,Zhengli Shi,Yigang Tong,Jingyun Ma +44 more
TL;DR: Analysis of viral samples from deceased piglets shows that a bat coronav virus was responsible for an outbreak of fatal disease in China and highlights the importance of the identification of coronavirus diversity and distribution in bats in order to mitigate future outbreaks of disease.
Journal ArticleDOI
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host.
Matae Ahn,Danielle E. Anderson,Qian Zhang,Qian Zhang,Chee Wah Tan,Beng Lee Lim,Katarina Luko,Ming Wen,Wan Ni Chia,Shailendra Mani,Loo Chien Wang,Justin H. J. Ng,Radoslaw M. Sobota,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Florent Ginhoux,Zhengli Shi,Aaron T. Irving,Lin-Fa Wang +18 more
TL;DR: Dampened activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in bat primary immune cells in response to infection with multiple zoonotic viruses is caused by decreased transcriptional priming, the presence of a unique splice variant and an altered leucine-rich repeat domain of bat NLRP3.
Journal ArticleDOI
Wuhan to World: The COVID-19 Pandemic.
Ashok Kumar,Ashok Kumar,Rita Singh,Rita Singh,Jaskaran Kaur,Jaskaran Kaur,Sweta Pandey,Sweta Pandey,Vinita Sharma,Vinita Sharma,Lovnish Thakur,Lovnish Thakur,Sangeeta Sati,Shailendra Mani,Shailendra Asthana,Tarun Kumar Sharma,Susmita Chaudhuri,Sankar Bhattacharyya,Niraj Kumar +18 more
TL;DR: In this article, the authors summarized the available knowledge about the pathogen and the disease, COVID-19, and provided a valuable resource to the scientific and clinical community and may help in faster development of the solution to combat the disease.
Journal ArticleDOI
Pichia pastoris-Expressed Dengue 2 Envelope Forms Virus-Like Particles without Pre-Membrane Protein and Induces High Titer Neutralizing Antibodies
Shailendra Mani,Lav Tripathi,Rajendra Raut,Poornima Tyagi,Upasana Arora,Tarani Kanta Barman,Ruchi Sood,Alka Galav,Wahala M.P.B. Wahala,Aravinda M. de Silva,Sathyamangalam Swaminathan,Navin Khanna +11 more
TL;DR: The formation of immunogenic DENV-2 E VLPs in the absence of pre-membrane protein highlights the potential of P. pastoris in developing non-replicating, safe, efficacious and affordable dengue vaccine.
Journal ArticleDOI
Identification of an anti-SARS-CoV-2 receptor-binding domain-directed human monoclonal antibody from a naive semisynthetic library
Hilal Ahmad Parray,Adarsh Kumar Chiranjivi,Shailendra Asthana,Naveen S Yadav,Tripti Shrivastava,Shailendra Mani,Chandresh Sharma,Preeti Vishwakarma,Supratik Das,Kamal S. Pindari,Subrata Sinha,Sweety Samal,Shubbir Ahmed,Rajesh Kumar +13 more
TL;DR: Given its high specificity and affinity, it is anticipated that these anti-CoV-2 antibodies will be useful as valuable reagents for accessing the antigenicity of vaccine candidates, as well as developing antibody-based therapeutics and diagnostics for CoV- 2.