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Beng Lee Lim
Researcher at National University of Singapore
Publications - 8
Citations - 854
Beng Lee Lim is an academic researcher from National University of Singapore. The author has contributed to research in topics: Immune system & Antibody. The author has an hindex of 4, co-authored 5 publications receiving 314 citations.
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Journal ArticleDOI
Evidence for SARS-CoV-2 related coronaviruses circulating in bats and pangolins in Southeast Asia.
Supaporn Wacharapluesadee,Chee Wah Tan,Patarapol Maneeorn,Prateep Duengkae,Feng Zhu,Yutthana Joyjinda,Thongchai Kaewpom,Wan Ni Chia,Weenassarin Ampoot,Beng Lee Lim,Kanthita Worachotsueptrakun,Vivian Chih Wei Chen,Nutthinee Sirichan,Chanida Ruchisrisarod,Apaporn Rodpan,Kirana Noradechanon,Thanawadee Phaichana,Niran Jantarat,Boonchu Thongnumchaima,Changchun Tu,Gary Crameri,Martha M. Stokes,Thiravat Hemachudha,Lin-Fa Wang +23 more
TL;DR: In this article, molecular and serological evidence of SARS-CoV-2 related coronaviruses (SC2r-CoVs) actively circulating in bats in Southeast Asia was reported.
Journal ArticleDOI
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection.
Nina Le Bert,Hannah E. Clapham,Anthony T. Tan,Wan Ni Chia,Christine Y.L. Tham,Jane Mingjie Lim,Kamini Kunasegaran,Linda Wei Lin Tan,Charles-Antoine Dutertre,Nivedita Shankar,Joey M.E. Lim,Louisa Jin Sun,Marina Zahari,Zaw Myo Tun,Vishakha Kumar,Beng Lee Lim,Siew Hoon Lim,Adeline Chia,Yee-Joo Tan,Yee-Joo Tan,Paul A. Tambyah,Shirin Kalimuddin,Shirin Kalimuddin,David C. Lye,Jenny G. Low,Jenny G. Low,Lin-Fa Wang,Wei Yee Wan,Li Yang Hsu,Antonio Bertoletti,Antonio Bertoletti,Clarence C. Tam,Clarence C. Tam +32 more
TL;DR: In this article, SARS-CoV-2-specific T cells in a cohort of asymptomatic and symptomatic COVID-19 patients after seroconversion were longitudinally studied.
Journal ArticleDOI
Dampened NLRP3-mediated inflammation in bats and implications for a special viral reservoir host.
Matae Ahn,Danielle E. Anderson,Qian Zhang,Qian Zhang,Chee Wah Tan,Beng Lee Lim,Katarina Luko,Ming Wen,Wan Ni Chia,Shailendra Mani,Loo Chien Wang,Justin H. J. Ng,Radoslaw M. Sobota,Charles-Antoine Dutertre,Charles-Antoine Dutertre,Florent Ginhoux,Zhengli Shi,Aaron T. Irving,Lin-Fa Wang +18 more
TL;DR: Dampened activation of the NLR family pyrin domain containing 3 (NLRP3) inflammasome in bat primary immune cells in response to infection with multiple zoonotic viruses is caused by decreased transcriptional priming, the presence of a unique splice variant and an altered leucine-rich repeat domain of bat NLRP3.
Posted ContentDOI
Highly functional virus-specific cellular immune response in asymptomatic SARS-CoV-2 infection
Nina Le Bert,Hannah E. Clapham,Anthony T. Tan,Wan Ni Chia,Christine Y.L. Tham,Jane Mingjie Lim,Kamini Kunasegaran,Linda Wei Lin Tan,Charles-Antoine Dutertre,Nivedita Shankar,Joey M.E. Lim,Louisa Jin Sun,Marina Zahari,Zaw Myo Tun,Vishakha Kumar,Beng Lee Lim,Siew Hoon Lim,Adeline Chia,Yee-Joo Tan,Paul A. Tambyah,Shirin Kalimuddin,Shirin Kalimuddin,David C. Lye,Jenny G. Low,Jenny G. Low,Lin-Fa Wang,Wei Yee Wan,Li Yang Hsu,Antonio Bertoletti,Antonio Bertoletti,Clarence C. Tam,Clarence C. Tam +31 more
TL;DR: Asymptomatic SARS-CoV-2 infected individuals are not characterized by a weak antiviral immunity; on the contrary, they mount a robust and highly functional virus-specific cellular immune response.