S
Shannon Smith
Researcher at Harvard University
Publications - 8
Citations - 3276
Shannon Smith is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Fulvestrant. The author has an hindex of 8, co-authored 8 publications receiving 2930 citations. Previous affiliations of Shannon Smith include J. Craig Venter Institute.
Papers
More filters
Journal ArticleDOI
Genome analysis of multiple pathogenic isolates of Streptococcus agalactiae: Implications for the microbial “pan-genome”
Hervé Tettelin,Vega Masignani,Michael J. Cieslewicz,Claudio Donati,Duccio Medini,Naomi L. Ward,Samuel V. Angiuoli,Jonathan Crabtree,Amanda L. Jones,A. Scott Durkin,Robert T. DeBoy,Tanja M. Davidsen,Marirosa Mora,Maria Scarselli,Immaculada Margarit Y Ros,Jeremy Peterson,Christopher R. Hauser,Jaideep P. Sundaram,William C. Nelson,Ramana Madupu,Lauren M. Brinkac,Robert J. Dodson,M. J. Rosovitz,Steven A. Sullivan,Sean C. Daugherty,Daniel H. Haft,Jeremy D. Selengut,Michelle L. Gwinn,Liwei Zhou,Nikhat Zafar,Hoda Khouri,Diana Radune,George Dimitrov,Kisha Watkins,Kevin J. B. O'Connor,Shannon Smith,Teresa Utterback,Owen White,Craig E. Rubens,Guido Grandi,Lawrence C. Madoff,Dennis L. Kasper,John L. Telford,Michael R. Wessels,Rino Rappuoli,Claire M. Fraser +45 more
TL;DR: The genomic sequence of six strains representing the five major disease-causing serotypes of Streptococcus agalactiae, the main cause of neonatal infection in humans, was generated and Mathematical extrapolation of the data suggests that the gene reservoir available for inclusion in the S. agalactic pan-genome is vast and that unique genes will continue to be identified even after sequencing hundreds of genomes.
Journal ArticleDOI
Comparative Genomics of Emerging Human Ehrlichiosis Agents
Julie C. Dunning Hotopp,Mingqun Lin,Ramana Madupu,Jonathan Crabtree,Samuel V. Angiuoli,Jonathan A. Eisen,Rekha Seshadri,Qinghu Ren,Martin Wu,Teresa Utterback,Shannon Smith,Matthew R. Lewis,Hoda Khouri,Chunbin Zhang,Hua Niu,Quan Lin,Norio Ohashi,Ning Zhi,William C. Nelson,Lauren M. Brinkac,Robert J. Dodson,M. J. Rosovitz,Jaideep P. Sundaram,Sean C. Daugherty,Tanja M. Davidsen,Anthony S. Durkin,Michelle L. Gwinn,Daniel H. Haft,Jeremy D. Selengut,Steven A. Sullivan,Nikhat Zafar,Liwei Zhou,Faiza H. Benahmed,Heather C. Forberger,Rebecca A. Halpin,Stephanie Mulligan,Jeffrey M. Robinson,Owen White,Yasuko Rikihisa,Hervé Tettelin +39 more
TL;DR: Analysis identified proteins potentially involved in vacuole confinement of the Anaplasmataceae, a life cycle involving a hematophagous vector, vertebrate pathogenesis, human pathogenesis and lack of transovarial transmission, which provide significant insights into the biology of these obligate intracellular pathogens.
Journal ArticleDOI
Genomic Alterations of Anaplastic Lymphoma Kinase May Sensitize Tumors to Anaplastic Lymphoma Kinase Inhibitors
Ultan McDermott,A. John Iafrate,Nathanael S. Gray,Toshi Shioda,Marie Classon,Shyamala Maheswaran,Wenjun Zhou,Hwan Geun Choi,Shannon Smith,Lori Dowell,Lindsey E. Ulkus,Georgiana Kuhlmann,Patricia Greninger,James G. Christensen,Daniel A. Haber,Jeffrey Settleman +15 more
TL;DR: Findings suggest that a subset of lung cancers, lymphomas, and neuroblastomas that harbor genomic ALK alterations may be clinically responsive to pharmacologic ALK inhibition.
Journal ArticleDOI
Comparative analysis of 87,000 expressed sequence tags from the fumonisin-producing fungus Fusarium verticillioides.
Daren W. Brown,Foo Cheung,Robert H. Proctor,Robert A. E. Butchko,Li Zheng,Yuandan Lee,Teresa Utterback,Shannon Smith,Tamara Feldblyum,Anthony E. Glenn,Ronald D. Plattner,David F. Kendra,Christopher D. Town,Catherine A. Whitelaw +13 more
TL;DR: Nine candidate fumonisin regulatory genes and a number of genes that may play a role in plant-fungal interaction were identified and evidence for a previously unidentified gene (FUM20) in the FUM gene cluster was provided.
Journal ArticleDOI
Antiestrogen-resistant subclones of MCF-7 human breast cancer cells are derived from a common monoclonal drug-resistant progenitor
Kathryn R. Coser,Ben S. Wittner,Noël F. Rosenthal,Sabrina C. Collins,Antonia Melas,Shannon Smith,Crystal J. Mahoney,Keiko Shioda,Kurt J. Isselbacher,Sridhar Ramaswamy,Toshi Shioda +10 more
TL;DR: The results suggest that the T/F-sublines are derived from a common monoclonal progenitor that lost transcriptomal responsiveness to antiestrogens as a consequence of genetic abnormalities many population doublings ago, not from the antiestrogen-sensitive cells in the same culture during the exposure toAntiestrogens.