S
Sharon Kean
Researcher at Robertson Centre for Biostatistics
Publications - 31
Citations - 4995
Sharon Kean is an academic researcher from Robertson Centre for Biostatistics. The author has contributed to research in topics: Randomized controlled trial & Population. The author has an hindex of 16, co-authored 28 publications receiving 3735 citations. Previous affiliations of Sharon Kean include University of Glasgow.
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Journal ArticleDOI
West of Scotland Coronary Prevention Study: Identification of high-risk groups and comparison with other cardiovascular intervention trials
J. Shepherd,Stuart M. Cobbe,AR Lorimer,James H. McKillop,Jane B. Ford,Christopher J. Packard,Peter W. Macfarlane,Chris Isles,MF Oliver,A. F. Lever,BW Brown,Jgg Ledingham,SJ Pocock,BM Rifkind,B. D. Vallance,David Ballantyne,L Anderson,D Duncan,Sharon Kean,A Lawrence,John J. McGrath,K Montgomery,John Norrie,M Percy,E Pomphrey,Andrew J. O. Whitehouse,Peter Cameron,P Parker,F Porteous,L Fletcher,C Kilday,D Shoat,S Latif,James L. Kennedy,M A Bell,R Birrell,M Mellies,J Meyer,W Campbell +38 more
Journal ArticleDOI
Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Renae J. Stefanetti,Michael I. Trenell,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Naveed Sattar,Roy Taylor +24 more
TL;DR: The findings show that, at 12 months, almost half of participants achieved remission to a non-diabetic state and off antidiabetic medications, from baseline to 12 months.
Journal ArticleDOI
Durability of a primary care-led weight-management intervention for remission of type 2 diabetes: 2-year results of the DiRECT open-label, cluster-randomised trial
Michael E. J. Lean,Wilma S Leslie,Alison C. Barnes,Naomi Brosnahan,George Thom,Louise McCombie,Carl Peters,Sviatlana Zhyzhneuskaya,Ahmad Al-Mrabeh,Kieren G. Hollingsworth,Angela M. Rodrigues,Lucia Rehackova,Ashley J. Adamson,Falko F. Sniehotta,John C. Mathers,H. M. Ross,Yvonne McIlvenna,Paul Welsh,Sharon Kean,Ian Ford,Alex McConnachie,Claudia-Martina Messow,Naveed Sattar,Roy Taylor +23 more
TL;DR: Sustained remission was linked to the extent of sustained weight loss, and the DiRECT programme sustained remissions at 24 months for more than a third of people with type 2 diabetes.
Journal ArticleDOI
Efficacy and safety of statin therapy in older people: a meta-analysis of individual participant data from 28 randomised controlled trials
Jane Armitage,Colin Baigent,Elizabeth H Barnes,D. John Betteridge,Lisa Blackwell,Michael A. Blazing,Louise Bowman,Eugene Braunwald,Robert P Byington,Christopher P. Cannon,Michael Clearfield,Helen M. Colhoun,Rory Collins,Björn Dahlöf,Kelly Davies,Barry R. Davis,James A. de Lemos,John R. Downs,Paul N. Durrington,Jonathan Emberson,Bengt Fellström,Marcus Flather,Ian Ford,Maria Grazia Franzosi,Jordan Fulcher,John H. Fuller,Curt D. Furberg,David L. Gordon,Shinya Goto,Antonio M. Gotto,Heather Halls,Charlie H.S. Harper,C. Morton Hawkins,William G. Herrington,Graham A. Hitman,Hallvard Holdaas,Lisa Holland,Alan G. Jardine,J. Wouter Jukema,John J.P. Kastelein,Sharon Kean,Anthony C Keech,Adrienne Kirby,John Kjekshus,Genell L. Knatterud,Robert H. Knopp,Wolfgang Koenig,Michael J. Koren,Vera Krane,Martin J Landray,John C. LaRosa,Eva Lonn,Peter W. Macfarlane,Stephen MacMahon,Aldo P. Maggioni,Roberto Marchioli,Ian C. Marschner,Borislava Mihaylova,Lemuel A. Moyé,Sabina A. Murphy,Haruo Nakamura,Andrew Neil,Connie B. Newman,Rachel O'Connell,Chris J. Packard,Sarah Parish,Terje R. Pedersen,Richard Peto,Marc A. Pfeffer,Neil Poulter,David Preiss,Christina Reith,Paul M. Ridker,Michele Robertson,Frank M. Sacks,Naveed Sattar,Roland E. Schmieder,Patrick W. Serruys,Peter S. Sever,John Shaw,Charles L. Shear,John Simes,Peter Sleight,Enti Spata,Luigi Tavazzi,Jonathan A. Tobert,Gianni Tognoni,Andrew Tonkin,Stella Trompet,John Varigos,Christoph Wanner,Hans Wedel,Harvey D. White,John Wikstrand,Lars Wilhelmsen,Kate Wilson,R. Young,Salim Yusuf,Faiez Zannad +98 more
TL;DR: A meta-analysis of data from all large statin trials to compare the effects of statin therapy at different ages observed a significant reduction in major vascular events in all age groups.
Journal ArticleDOI
Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism.
David J. Stott,Nicolas Rodondi,Patricia M. Kearney,Ian Ford,Rudi G. J. Westendorp,Simon P. Mooijaart,Naveed Sattar,Carole E. Aubert,Drahomir Aujesky,Douglas C. Bauer,Christine Baumgartner,Manuel R. Blum,John Browne,Stephen Byrne,Tinh-Hai Collet,Olaf M. Dekkers,Wendy P. J. den Elzen,Robert S. Du Puy,Graham Ellis,Martin Feller,Carmen Floriani,Kirsty Hendry,Caroline Hurley,J. Wouter Jukema,Sharon Kean,Maria Kelly,Danielle Krebs,Peter Langhorne,Gemma McCarthy,Vera J. C. McCarthy,Alex McConnachie,Mairi McDade,Martina Messow,Anne Marie O'Flynn,David O'Riordan,Rosalinde K. E. Poortvliet,Terence J. Quinn,Audrey Russell,Carol Sinnott,Jan W. A. Smit,H. Anette Van Dorland,Kieran A. Walsh,Elaine Walsh,Torquil Watt,Robbie Wilson,Jacobijn Gussekloo +45 more
TL;DR: Levothyroxine provided no apparent benefits in older persons with subclinical hypothyroidism and there was no significant excess of serious adverse events prespecified as being of special interest.