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Erika Vacchelli
Researcher at Institut Gustave Roussy
Publications - 82
Citations - 10519
Erika Vacchelli is an academic researcher from Institut Gustave Roussy. The author has contributed to research in topics: Immunogenic cell death & Immune system. The author has an hindex of 48, co-authored 79 publications receiving 8773 citations. Previous affiliations of Erika Vacchelli include Pierre-and-Marie-Curie University & French Institute of Health and Medical Research.
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Journal ArticleDOI
Autophagy-dependent anticancer immune responses induced by chemotherapeutic agents in mice.
Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Isabelle Martins,Isabelle Martins,Isabelle Martins,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Yuting Ma,Patrizia Pellegatti,Shensi Shen,Shensi Shen,Shensi Shen,Oliver Kepp,Oliver Kepp,Oliver Kepp,Marie Scoazec,Grégoire Mignot,Santiago Rello-Varona,Santiago Rello-Varona,Santiago Rello-Varona,Maximilien Tailler,Maximilien Tailler,Maximilien Tailler,Laurie Menger,Laurie Menger,Laurie Menger,Erika Vacchelli,Erika Vacchelli,Erika Vacchelli,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,François Ghiringhelli,Francesco Di Virgilio,Laurence Zitvogel,Guido Kroemer +40 more
TL;DR: It is demonstrated that autophagy, which is often disabled in cancer, is dispensable for chemotherapy-induced cell death but required for its immunogenicity, and increased extracellular ATP concentrations improve the efficacy of antineoplastic chemotherapies when Autophagy is disabled.
Journal ArticleDOI
Consensus guidelines for the detection of immunogenic cell death
Oliver Kepp,Laura Senovilla,Ilio Vitale,Erika Vacchelli,Sandy Adjemian,Patrizia Agostinis,Lionel Apetoh,Fernando Aranda,Vincenzo Barnaba,Norma Bloy,Laura Bracci,Karine Breckpot,David Brough,Aitziber Buqué,Maria G. Castro,Mara Cirone,María Isabel Colombo,Isabelle Cremer,Sandra Demaria,Luciana Dini,Aristides G. Eliopoulos,Alberto Faggioni,Silvia C. Formenti,Jitka Fucikova,Lucia Gabriele,Udo S. Gaipl,Jérôme Galon,Abhishek D. Garg,François Ghiringhelli,Nathalia A. Giese,Zong Sheng Guo,Akseli Hemminki,Martin Herrmann,James W. Hodge,Stefan Holdenrieder,Jamie Honeychurch,Hong-Min Hu,Xing Huang,Timothy M Illidge,Koji Kono,Mladen Korbelik,Dmitri V. Krysko,Sherene Loi,Pedro R. Lowenstein,Enrico Lugli,Yuting Ma,Frank Madeo,Angelo A. Manfredi,Isabelle Martins,Domenico Mavilio,Laurie Menger,Nicolò Merendino,Michael Michaud,Grégoire Mignot,Karen L. Mossman,Gabriele Multhoff,Rudolf Oehler,Fabio Palombo,Theocharis Panaretakis,Jonathan Pol,Enrico Proietti,Jean-Ehrland Ricci,Chiara Riganti,Patrizia Rovere-Querini,Anna Rubartelli,Antonella Sistigu,Mark J. Smyth,Juergen Sonnemann,Radek Spisek,John Stagg,Abdul Qader Sukkurwala,Eric Tartour,Andrew Thorburn,Stephen H. Thorne,Peter Vandenabeele,Francesca Velotti,Samuel T Workenhe,Haining Yang,Wei-Xing Zong,Laurence Zitvogel,Guido Kroemer,Lorenzo Galluzzi +81 more
TL;DR: Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed.
Journal ArticleDOI
Anticancer chemotherapy-induced intratumoral recruitment and differentiation of antigen-presenting cells.
Yuting Ma,Yuting Ma,Yuting Ma,Sandy Adjemian,Sandy Adjemian,Sandy Adjemian,Stephen R. Mattarollo,Takahiro Yamazaki,Takahiro Yamazaki,Takahiro Yamazaki,Laetitia Aymeric,Laetitia Aymeric,Laetitia Aymeric,Heng Yang,João Paulo Portela Catani,Dalil Hannani,Dalil Hannani,Dalil Hannani,Helene Duret,Kim Steegh,Isabelle Martins,Isabelle Martins,Isabelle Martins,Frédéric Schlemmer,Frédéric Schlemmer,Frédéric Schlemmer,Mickaël Michaud,Mickaël Michaud,Mickaël Michaud,Oliver Kepp,Oliver Kepp,Oliver Kepp,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Abdul Qader Sukkurwala,Laurie Menger,Laurie Menger,Laurie Menger,Erika Vacchelli,Erika Vacchelli,Erika Vacchelli,Nathalie Droin,Nathalie Droin,Lorenzo Galluzzi,Lorenzo Galluzzi,Roman Krzysiek,Siamon Gordon,Philip R. Taylor,Peter van Endert,Eric Solary,Eric Solary,Eric Solary,Mark J. Smyth,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Guido Kroemer +56 more
Journal ArticleDOI
Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A
Guillermo Mariño,Federico Pietrocola,Tobias Eisenberg,Yongli Kong,Shoaib Ahmad Malik,Aleksandra Andryushkova,Sabrina Schroeder,Tobias Pendl,Alexandra Harger,Mireia Niso-Santano,Naoufal Zamzami,Marie Scoazec,Silvère Durand,David Enot,Álvaro F. Fernández,Isabelle Martins,Oliver Kepp,Laura Senovilla,Chantal Bauvy,Chantal Bauvy,Eugenia Morselli,Erika Vacchelli,Martin V. Bennetzen,Christoph Magnes,Frank Sinner,Thomas R. Pieber,Carlos López-Otín,Maria Chiara Maiuri,Patrice Codogno,Patrice Codogno,Jens S. Andersen,Joseph A. Hill,Frank Madeo,Guido Kroemer +33 more
TL;DR: It is shown that nutrient starvation causes rapid depletion of AcCoA, and multiple distinct manipulations designed to increase or reduce cytosolic Ac CoA led to the suppression or induction of autophagy, respectively, both in cultured human cells and in mice, delineating Ac coenzyme A-centered pharmacological strategies that allow for the therapeutic manipulation ofautophagy.
Journal ArticleDOI
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Federico Pietrocola,Federico Pietrocola,Jonathan Pol,Erika Vacchelli,Erika Vacchelli,Shuan Rao,David Enot,Elisa E. Baracco,Sarah Levesque,Francesca Castoldi,Nicolas Jacquelot,Takahiro Yamazaki,Laura Senovilla,Guillermo Mariño,Guillermo Mariño,Fernando Aranda,Fernando Aranda,Sylvère Durand,Valentina Sica,Alexis Chery,Sylvie Lachkar,Verena Sigl,Norma Bloy,Aitziber Buqué,Simonetta Falzoni,Bernhard Ryffel,Bernhard Ryffel,Lionel Apetoh,Lionel Apetoh,Francesco Di Virgilio,Frank Madeo,Maria Chiara Maiuri,Laurence Zitvogel,Beth Levine,Josef M. Penninger,Guido Kroemer +35 more
TL;DR: Short-term fasting or treatment with several chemically unrelated autophagy-inducing CRMs, including hydroxycitrate and spermidine, improved the inhibition of tumor growth by chemotherapy in vivo and improved anticancer immunosurveillance and reducing tumor mass.