S
Shigehiro Katayama
Researcher at Saitama Medical University
Publications - 251
Citations - 11344
Shigehiro Katayama is an academic researcher from Saitama Medical University. The author has contributed to research in topics: Diabetes mellitus & Type 2 diabetes. The author has an hindex of 49, co-authored 251 publications receiving 10637 citations.
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Journal ArticleDOI
VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death
Diether Lambrechts,Erik Storkebaum,Masafumi Morimoto,Jurgen Del-Favero,Frederik Desmet,Stefan L. Marklund,Sabine Wyns,Vincent Thijs,Jörgen Andersson,Ingrid van Marion,Ammar Al-Chalabi,Stéphanie Bornes,Rhiannon Musson,Valerie K. Hansen,Lars Beckman,Rolf Adolfsson,Hardev Pall,Hervé Prats,Severine Vermeire,Paul Rutgeerts,Shigehiro Katayama,Takuya Awata,Nigel Leigh,Loïc Lang-Lazdunski,Mieke Dewerchin,Christopher Shaw,Lieve Moons,Robert Vlietinck,Robert Vlietinck,Karen E. Morrison,Wim Robberecht,Christine Van Broeckhoven,Desire Collen,Peter M. Andersen,Peter Carmeliet +34 more
TL;DR: It is indicated that VEGF is a modifier of motoneuron degeneration in human ALS and unveil a therapeutic potential of Vegfa for stressed motoneurons in mice.
Journal ArticleDOI
Olmesartan for the Delay or Prevention of Microalbuminuria in Type 2 Diabetes
Hermann Haller,Sadayoshi Ito,Joseph L. Izzo,Andrzej Januszewicz,Shigehiro Katayama,Jan Menne,Albert Mimran,Ton J. Rabelink,Eberhard Ritz,Luis M. Ruilope,Lars Christian Rump,Giancarlo Viberti +11 more
TL;DR: Olmesartan was associated with a delayed onset of microalbuminuria, even though blood-pressure control in both groups was excellent according to current standards.
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A Common Polymorphism in the 5′-Untranslated Region of the VEGF Gene Is Associated With Diabetic Retinopathy in Type 2 Diabetes
Takuya Awata,Kiyoaki Inoue,Susumu Kurihara,Tomoko Ohkubo,Masaki Watanabe,Kouichi Inukai,Ikuo Inoue,Shigehiro Katayama +7 more
TL;DR: The data suggest that the C(-634)G polymorphism in the 5'UTR of the VEGF gene is a novel genetic risk factor for diabetic retinopathy.
Journal ArticleDOI
Essential Role of p38 Mitogen-activated Protein Kinase in Cathepsin K Gene Expression during Osteoclastogenesis through Association of NFATc1 and PU.1 *
Masahito Matsumoto,Masakazu Kogawa,Seiki Wada,Hiroshi Takayanagi,Masafumi Tsujimoto,Shigehiro Katayama,Koji Hisatake,Yasuhisa Nogi +7 more
TL;DR: The results suggest that the RANKL-induced cathepsin K gene expression is cooperatively regulated by the combination of the transcription factors and p38 MAP kinase in a gradual manner.
Journal ArticleDOI
Lipophilic HMG-CoA reductase inhibitor has an anti-inflammatory effect
Ikuo Inoue,Sei-ichi Goto,Kasumi Mizotani,Takuya Awata,Toshiyuki Mastunaga,Shin-ichiro Kawai,Takanori Nakajima,Shigeru Hokari,Tugikazu Komoda,Shigehiro Katayama +9 more
TL;DR: In this paper, the effects of four 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (pravastatin, simvastatin and fluvastatatin) on the production and expression of inflammatory cytokines and on enzyme expression involving prostaglandin and superoxide production in cultured human umbilical vein endothelial cells (HUVEC) were examined.