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Shin-ichi Muramatsu
Researcher at Jichi Medical University
Publications - 189
Citations - 6916
Shin-ichi Muramatsu is an academic researcher from Jichi Medical University. The author has contributed to research in topics: Dopamine & Adeno-associated virus. The author has an hindex of 40, co-authored 165 publications receiving 5972 citations. Previous affiliations of Shin-ichi Muramatsu include Meijo University & National Institutes of Health.
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Journal ArticleDOI
Nurr1 Is Required for Maintenance of Maturing and Adult Midbrain Dopamine Neurons
Banafsheh Kadkhodaei,Takehito Ito,Eliza Joodmardi,Bengt Mattsson,Claude Rouillard,Manolo Carta,Shin-ichi Muramatsu,Chiho Sumi-Ichinose,Takahide Nomura,Daniel Metzger,Pierre Chambon,Eva Lindqvist,Nils-Göran Larsson,Lars Olson,Anders Björklund,Hiroshi Ichinose,Thomas Perlmann +16 more
TL;DR: The results show that developmental pathways play key roles for the maintenance of terminally differentiated neurons and suggest that disrupted function of Nurr1 and other developmental transcription factors may contribute to neurodegenerative disease.
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Unrestricted Hepatocyte Transduction with Adeno-Associated Virus Serotype 8 Vectors in Mice
TL;DR: In this article, the authors performed a dose-response study by injecting mice with -galactosidase-expressing recombinant adeno-associated virus (rAAV)1 and rAAV8 vectors via the portal vein.
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A phase I study of aromatic L-amino acid decarboxylase gene therapy for Parkinson's disease.
Shin-ichi Muramatsu,Ken-ichi Fujimoto,Seiya Kato,Hiroaki Mizukami,Sayaka Asari,Kunihiko Ikeguchi,Tadataka Kawakami,Masashi Urabe,Akihiro Kume,Toshihiko Sato,Watanabe Eiju,Keiya Ozawa,Imaharu Nakano +12 more
TL;DR: The findings provide class IV evidence regarding the safety and efficacy of AADC gene therapy and warrant further evaluation in a randomized, controlled, phase 2 setting.
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Neuroprotective effects of glial cell line-derived neurotrophic factor mediated by an adeno-associated virus vector in a transgenic animal model of amyotrophic lateral sclerosis.
Lijun Wang,Yan-Yan Lu,Shin-ichi Muramatsu,Kunihiko Ikeguchi,Ken-ichi Fujimoto,Takashi Okada,Hiroaki Mizukami,Takashi Matsushita,Yutaka Hanazono,Akihiro Kume,Toshiharu Nagatsu,Keiya Ozawa,Imaharu Nakano +12 more
TL;DR: It is shown here that AAV-GDNF leads to substantial and long-lasting expression of transgenic GDNF in a large number of myofibers with its accumulation at the sites of neuromuscular junctions, indicating that A AV-mediated GDNF delivery to the muscle is a promising means of gene therapy for ALS.
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Presynaptic localization of neprilysin contributes to efficient clearance of amyloid-beta peptide in mouse brain
Nobuhisa Iwata,Hiroaki Mizukami,Keiro Shirotani,Yoshie Takaki,Shin-ichi Muramatsu,Bao Lu,Norma P. Gerard,Craig Gerard,Keiya Ozawa,Takaomi C. Saido +9 more
TL;DR: Presynaptic neprilysin has been demonstrated to degrade Aβ efficiently and to retard development of amyloid pathology.