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Shinji Kohsaka
Researcher at University of Tokyo
Publications - 107
Citations - 5257
Shinji Kohsaka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 18, co-authored 73 publications receiving 3728 citations. Previous affiliations of Shinji Kohsaka include Memorial Sloan Kettering Cancer Center & Juntendo University.
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Journal ArticleDOI
Tumour exosome integrins determine organotropic metastasis
Ayuko Hoshino,Bruno Costa-Silva,Tang-Long Shen,Gonçalo Rodrigues,Ayako Hashimoto,Milica Tesic Mark,Henrik Molina,Shinji Kohsaka,Angela Di Giannatale,Sophia Ceder,Swarnima Singh,Caitlin Williams,Nadine Soplop,Kunihiro Uryu,Lindsay A. Pharmer,Tari A. King,Linda Bojmar,Alexander E. Davies,Yonathan Ararso,Tuo Zhang,Haiying Zhang,Jonathan M. Hernandez,Joshua Mitchell Weiss,Vanessa D. Dumont-Cole,Kimberly Kramer,Leonard H. Wexler,Aru Narendran,Gary K. Schwartz,John H. Healey,Per Sandström,Knut Jørgen Labori,Elin H. Kure,Paul M. Grandgenett,Michael A. Hollingsworth,Maria de Sousa,Sukwinder Kaur,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Mary S. Brady,Øystein Fodstad,Volkmar Müller,Klaus Pantel,Andy J. Minn,Mina J. Bissell,Benjamin A. Garcia,Yibin Kang,Yibin Kang,Vinagolu K. Rajasekhar,Cyrus M. Ghajar,Irina Matei,Héctor Peinado,Jacqueline Bromberg,Jacqueline Bromberg,David Lyden +55 more
TL;DR: It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.
Journal ArticleDOI
Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults
Takahiko Yasuda,Takahiko Yasuda,Shinobu Tsuzuki,Masahito Kawazu,Fumihiko Hayakawa,Shinya Kojima,Toshihide Ueno,Naoto Imoto,Shinji Kohsaka,Akiko Kunita,Koichiro Doi,Toru Sakura,Toshiaki Yujiri,Eisei Kondo,Katsumichi Fujimaki,Yasunori Ueda,Yasutaka Aoyama,Shigeki Ohtake,Junko Takita,Eirin Sai,Masafumi Taniwaki,Mineo Kurokawa,Shinichi Morishita,Masashi Fukayama,Hitoshi Kiyoi,Yasushi Miyazaki,Tomoki Naoe,Hiroyuki Mano +27 more
TL;DR: The data show that DUX4 can become an oncogenic driver as a result of somatic chromosomal rearrangements and that AYA-ALL may be a clinical entity distinct from ALL at other ages, and that Dux4 fusions were preferentially detected in the AYA generation.
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A method of high-throughput functional evaluation of EGFR gene variants of unknown significance in cancer
Shinji Kohsaka,Masaaki Nagano,Toshihide Ueno,Yoshiyuki Suehara,Takuo Hayashi,Naoko Shimada,Kazuhisa Takahashi,Kenji Suzuki,Kazuya Takamochi,Fumiyuki Takahashi,Hiroyuki Mano,Hiroyuki Mano +11 more
TL;DR: The MANO method revealed that some EGFR mutants that are highly resistant to all types of TKIs are sensitive to cetuximab, which support the importance of examining the clinical relevance of uncommon mutations within EGFR and of evaluating the functions of such mutations in combination.
Journal ArticleDOI
STAT3 Inhibition Overcomes Temozolomide Resistance in Glioblastoma by Downregulating MGMT Expression
Shinji Kohsaka,Lei Wang,Kazuhiro Yachi,Roshan Mahabir,Takuhito Narita,Tamio Itoh,Mishie Tanino,Taichi Kimura,Hiroshi Nishihara,Shinya Tanaka +9 more
TL;DR: Immunohistochemical analysis of 44 malignant glioma specimens showed significant positive correlation between expression levels of MGMT and phosphorylated STAT3, suggesting STAT3 inhibitor might be one of the candidate reagents for combination therapy with temozolomide for patients with Templo-resistant GBM.
Journal ArticleDOI
A recurrent neomorphic mutation in MYOD1 defines a clinically aggressive subset of embryonal rhabdomyosarcoma associated with PI3K-AKT pathway mutations.
Shinji Kohsaka,Neerav Shukla,Nabahet Ameur,Tatsuo Ito,Charlotte K.Y. Ng,Lu Wang,Diana Lim,Angela Marchetti,Agnes Viale,Mono Pirun,Nicholas D. Socci,Li-Xuan Qin,Raf Sciot,Julia A. Bridge,Samuel Singer,Paul A. Meyers,Leonard H. Wexler,Frederic G. Barr,Snjezana Dogan,Jonathan A. Fletcher,Jorge S. Reis-Filho,Marc Ladanyi +21 more
TL;DR: This work reports the discovery of a recurrent somatic mutation encoding p.Leu122Arg in the myogenic transcription factor MYOD1 in a distinct subset of ERMS tumors with poor outcomes that also often contain mutations altering PI3K-AKT pathway components.