Shinya Yamada

TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.

TL;DR: The respective conserved amino acids in NP may be critical for the assembly and/or incorporation of sets of eight vRNA segments in viral replication, resulting in significant growth defects of viruses possessing these substitutions.

TL;DR: Using an alternative reverse genetics system for influenza virus using the canine polymerase I (PolI) promoter sequence that works efficiently in the Madin-Darby canine kidney cell line, a cell line approved for human vaccine production, this work was able to generate H5N1 vaccine seed viruses more efficiently.

TL;DR: It is found that swine isolates were less virulent to mice than avian isolates, suggesting that the viruses became attenuated during their replication in pigs, and continuous surveillance of H5N1 viruses among pigs is clearly warranted.

TL;DR: Findings identify Java Island as the epicenter of the Indonesian H5N1 virus expansion, and shows a new sublineage that did not belong to any of the present clades.