Hirohito Ishigaki

TL;DR: It is shown that CA04 is sensitive to approved and experimental antiviral drugs, suggesting that these compounds could function as a first line of defence against the recently declared S-OIV pandemic.

TL;DR: Major histocompatibility complex (MHC) matching improves graft survival rates after organ transplantation and in macaques, MHC-matched iPSC-derived neurons provide better engraftment in the brain, with a lower immune response and higher survival of the transplanted neurons.

TL;DR: The data suggest that the attenuated interferon-induced activation of innate immunity, apoptosis, and antigen presentation in the early phase of H5N1 virus infection leads to subsequent severe disease outcome, and provides insight into the pathogenesis of H 5N1 viruses in mammals.

TL;DR: Large scale genetic screening of the Filipino macaque population would identify high-frequency Mafa-class I haplotypes that could be used as MHC control animals for the benefit of biomedical research.

TL;DR: The macaque model enables prediction of the frequency of emerging H7N9 virus resistant to NA inhibitors in vivo, and monitoring of the emergence of variants is required during treatment of H7n9 influenza virus infection with NA inhibitors.