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Shu Meng
Researcher at Temple University
Publications - 15
Citations - 626
Shu Meng is an academic researcher from Temple University. The author has contributed to research in topics: Cytokine & Proinflammatory cytokine. The author has an hindex of 11, co-authored 15 publications receiving 536 citations. Previous affiliations of Shu Meng include Houston Methodist Hospital.
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Journal ArticleDOI
Blockade of NOX2 and STIM1 signaling limits lipopolysaccharide-induced vascular inflammation.
Rajesh Kumar Gandhirajan,Shu Meng,Harish C. Chandramoorthy,Karthik Mallilankaraman,Salvatore Mancarella,Hui Gao,Roshanak Razmpour,Xiaofeng Yang,Steven R. Houser,Ju Chen,Walter J. Koch,Hong Wang,Jonathan Soboloff,Donald L. Gill,Muniswamy Madesh +14 more
TL;DR: The results indicate that ROS-driven Ca2+ signaling promotes vascular barrier dysfunction and that the SOCe machinery may provide crucial therapeutic targets to limit sepsis-induced ALI.
Journal ArticleDOI
Early Hyperlipidemia Promotes Endothelial Activation via a Caspase-1-Sirtuin 1 Pathway
Ying Yin,Xinyuan Li,Xiaojin Sha,Hang Xi,Ya-Feng Li,Ying Shao,Jietang Mai,Anthony Virtue,Jahaira Lopez-Pastrana,Shu Meng,Douglas G. Tilley,M. Alexandra Monroy,Eric T. Choi,Craig J. Thomas,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +16 more
TL;DR: It is demonstrated for the first time that early hyperlipidemia promotes EC activation before monocyte recruitment via a caspase-1–sirtuin 1–activator protein-1 pathway, which provides an important insight into the development of novel therapeutics for blocking caspasing-1 activation as early intervention of metabolic cardiovascular diseases and inflammations.
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Interleukin-35 Inhibits Endothelial Cell Activation by Suppressing MAPK-AP-1 Pathway
Xiaojin Sha,Shu Meng,Xinyuan Li,Hang Xi,Massimo Maddaloni,David W. Pascual,Huimin Shan,Xiaohua Jiang,Hong Wang,Xiaofeng Yang +9 more
TL;DR: It is suggested that IL-35 is an attractive novel therapeutic reagent for sepsis and cardiovascular diseases because it inhibits vascular response in acute inflammation and attenuates LPS-induced secretion of proinflammatory cytokines/chemokines.
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Hyperhomocysteinemia Potentiates Hyperglycemia-induced Inflammatory Monocyte Differentiation and Atherosclerosis
Pu Fang,Daqing Zhang,Zhongjian Cheng,Chenghui Yan,Xiaohua Jiang,Warren D. Kruger,Shu Meng,Erland Arning,Teodoro Bottiglieri,Eric T. Choi,Yaling Han,Xiaofeng Yang,Hong Wang +12 more
TL;DR: It is demonstrated that HHcy and HG accelerated atherosclerosis and increased lesion monocytes and macrophages and further increased inflammatory MC and MØ levels in peripheral tissues and HHcy-lowering reversed circulating mononuclear cells, MC, and inflammatoryMC and MC-derived M Ø levels.
Journal ArticleDOI
Homocysteine induces inflammatory transcriptional signaling in monocytes.
TL;DR: Hcy is a pro-inflammatory amino acid and induces inflammatory transcriptional signal pathways mediated by class 1 TFs, which are referred to as putative Hcy-responsive TFs.