Shuki Mizutani

TL;DR: It is demonstrated that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially fromTyk2 function in mice.

TL;DR: It is demonstrated that WAS protein expression is a useful tool for predicting long-term prognosis for patients with WAS/XLT and hematopoietic stem cell transplantation should be considered, especially for WASP-negative patients, while the patients are young to improve prognosis.

TL;DR: The data suggest that specific chemical exposures of the fetus during pregnancy may cause MLL gene fusions, and the widespread use of dipyrone, Baygon, and other carbamate-based insecticides in certain settings is urgently required.

TL;DR: It is shown that the ATM-dependent activation of Chk2 by γ- radiation requires Nbs1, the gene product involved in the Nijmegen breakage syndrome (NBS), a disorder that shares with AT a variety of phenotypic defects including chromosome fragility, radiosensitivity, and radioresistant DNA synthesis, and suggest that checkpoint defects in NBS cells may result from the inability to activate Chk1.

TL;DR: The results indicate the existence of prognosis-associated genes that are independent of cell lineage and cytogenetic abnormalities, and they can provide therapeutic direction for individual risk-adapted therapy for pediatric AML patients.