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Fumio Bessho
Researcher at Kyorin University
Publications - 34
Citations - 1718
Fumio Bessho is an academic researcher from Kyorin University. The author has contributed to research in topics: Leukemia & Endoplasmic reticulum. The author has an hindex of 17, co-authored 33 publications receiving 1601 citations. Previous affiliations of Fumio Bessho include Nagoya University.
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Journal ArticleDOI
Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity
Yoshiyuki Minegishi,Masako Saito,Tomohiro Morio,Ken Watanabe,Kazunaga Agematsu,Shigeru Tsuchiya,Hidetoshi Takada,Toshiro Hara,Nobuaki Kawamura,Tadashi Ariga,Hideo Kaneko,Naomi Kondo,Ikuya Tsuge,Akihiro Yachie,Yukio Sakiyama,Tsutomu Iwata,Fumio Bessho,Tsutomu Oh-ishi,Kosuke Joh,Kohsuke Imai,Kazuhiro Kogawa,Miwa Shinohara,Mikiya Fujieda,Hiroshi Wakiguchi,Srdjan Pasic,Mario Abinun,Hans D. Ochs,Eleonore D. Renner,Eleonore D. Renner,Annette Jansson,Bernd H. Belohradsky,Ayse Metin,Norio Shimizu,Shuki Mizutani,Toshio Miyawaki,Shigeaki Nonoyama,Hajime Karasuyama +36 more
TL;DR: It is demonstrated that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially fromTyk2 function in mice.
Journal ArticleDOI
Improved outcome in the treatment of pediatric multifocal Langerhans cell histiocytosis: Results from the Japan Langerhans Cell Histiocytosis Study Group-96 protocol study.
Akira Morimoto,Ikushima S,Naoko Kinugawa,Eiichi Ishii,Urara Kohdera,Masahiro Sako,Junichiro Fujimoto,Fumio Bessho,Keizo Horibe,Yukiko Tsunematsu,Shinsaku Imashuku +10 more
TL;DR: The treatment outcome of multifocal childhood Langerhans cell histiocytosis has not been satisfactory and has resulted in poor therapeutic responses with high mortality and a high incidence of reactivation with late sequelae.
Journal Article
Frequency and clinical significance of the MLL gene rearrangements in infant acute leukemia.
Tomohiko Taki,Kohmei Ida,Fumio Bessho,R Hanada,Akira Kikuchi,Katsuya Yamamoto,Masahiro Sako,Masahiro Tsuchida,Masao Seto,Ryuzo Ueda,Yasuhide Hayashi +10 more
TL;DR: It is suggested that infant ALL should be treated on different chemotherapy protocols according to the presence or absence of MLL gene rearrangement, as it is strongly associated with poor prognosis.
Journal ArticleDOI
Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia
Yoshiyuki Kosaka,Hiroshi Yagasaki,Kimihiko Sano,Ryoji Kobayashi,Hiroshi Ayukawa,Takashi Kaneko,Hiromasa Yabe,Masahiro Tsuchida,Hideo Mugishima,Akira Ohara,Akira Morimoto,Yoshitoshi Otsuka,Shouichi Ohga,Fumio Bessho,Tatsutoshi Nakahata,Ichiro Tsukimoto,Seiji Kojima +16 more
TL;DR: It is suggested that SCT from an alternative donor offers a better chance of FFS than a second IST in patients not responding to an initial IST in children with acquired aplastic anemia who failed to respond to anInitial IST.
Journal ArticleDOI
The effect of dexamethasone on defective nephrin transport caused by ER stress: a potential mechanism for the therapeutic action of glucocorticoids in the acquired glomerular diseases.
Fujii Y,Jamshid Khoshnoodi,Hitoshi Takenaka,Makoto Hosoyamada,Aya Nakajo,Fumio Bessho,Akihiko Kudo,Shori Takahashi,Y Arimura,Akira Yamada,T Nagasawa,Vesas Ruotsalainen,Karl Tryggvason,Amy S. Lee,Kunimasa Yan +14 more
TL;DR: The results suggest that ER-stress in podocytes may cause alteration of nephrin N-glycosylation, which may be an underlying factor in the pathomechanism of the proteinuria in nephrotic syndrome.