Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity
Yoshiyuki Minegishi,Masako Saito,Tomohiro Morio,Ken Watanabe,Kazunaga Agematsu,Shigeru Tsuchiya,Hidetoshi Takada,Toshiro Hara,Nobuaki Kawamura,Tadashi Ariga,Hideo Kaneko,Naomi Kondo,Ikuya Tsuge,Akihiro Yachie,Yukio Sakiyama,Tsutomu Iwata,Fumio Bessho,Tsutomu Oh-ishi,Kosuke Joh,Kohsuke Imai,Kazuhiro Kogawa,Miwa Shinohara,Mikiya Fujieda,Hiroshi Wakiguchi,Srdjan Pasic,Mario Abinun,Hans D. Ochs,Eleonore D. Renner,Eleonore D. Renner,Annette Jansson,Bernd H. Belohradsky,Ayse Metin,Norio Shimizu,Shuki Mizutani,Toshio Miyawaki,Shigeaki Nonoyama,Hajime Karasuyama +36 more
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TLDR
It is demonstrated that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially fromTyk2 function in mice.About:
This article is published in Immunity.The article was published on 2006-11-01 and is currently open access. It has received 671 citations till now. The article focuses on the topics: Tyrosine kinase 2 & Janus kinase.read more
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Interferon-inducible antiviral effectors
TL;DR: This Review discusses four main effector pathways of the IFN-mediated antiviral response: the Mx GTPase pathway, the 2′,5′-oligoadenylate-synthetase-directed ribonuclease L pathways, the protein kinase R pathway and the ISG15 ubiquitin-like pathway.
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CD4 T cells: fates, functions, and faults
Jinfang Zhu,William E. Paul +1 more
TL;DR: Much of what is known about the 4 CD4 T-cell subsets is summarized, including the history of their discovery, their unique cytokine products and related functions, their distinctive expression of cell surface receptors and their characteristic transcription factors, the regulation of their fate determination, and the consequences of their abnormal activation.
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The IL-23-IL-17 immune axis: from mechanisms to therapeutic testing
TL;DR: This Review focuses on the recent advances that have been made regarding the transcriptional control of TH 17 cell plasticity and stability, as well as the effector functions of TH17 cells, and highlights the mechanisms of IL-17 signalling in mesenchymal and barrier epithelial tissues.
Journal ArticleDOI
The JAK-STAT Signaling Pathway: Input and Output Integration
TL;DR: This work discusses how diverse outcomes in gene expression result from regulatory events that effect the JAK1-STAT3 pathway, common to both receptors and considers how the suppressor of cytokine signaling (SOCS) proteins regulate the quality and quantity of STAT signals from cytokine receptors.
Journal ArticleDOI
STAT3 Mutations in the Hyper-IgE Syndrome
Steven M. Holland,Frank R. DeLeo,Houda Elloumi,Amy P. Hsu,Gulbu Uzel,Nina N. Brodsky,Alexandra F. Freeman,Andrew P. Demidowich,Joie Davis,Maria L. Turner,Victoria L. Anderson,Dirk Darnell,Pamela Welch,Douglas B. Kuhns,David M. Frucht,Harry L. Malech,John I. Gallin,Scott D. Kobayashi,Adeline R. Whitney,Jovanka M. Voyich,James M. Musser,Cristina Woellner,Alejandro A. Schäffer,Jennifer M. Puck,Bodo Grimbacher +24 more
TL;DR: Mutations in STAT3 underlie sporadic and dominant forms of the hyper-IgE syndrome, an immunodeficiency syndrome involving increased innate immune response, recurrent infections, and complex somatic features.
References
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Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.
Birgit Oppmann,Robin Lesley,Bianca Blom,Jackie C. Timans,Yuming Xu,Brisdell Hunte,Felix Vega,Nancy Yu,Jing Wang,Komal Singh,Francesca Zonin,Elena Vaisberg,Tatyana Churakova,Man ru Liu,Daniel M. Gorman,Janet Wagner,Sandra Zurawski,Yong-Jun Liu,John S. Abrams,Kevin W. Moore,Donna Rennick,Rene de Waal-Malefyt,Charles H. Hannum,J. Fernando Bazan,Robert A. Kastelein +24 more
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Cytokine receptor signalling
TL;DR: Many cell functions are regulated by members of the cytokine receptor superfamily, a family of transcription factors that contribute to the diversity of cytokine responses.
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TL;DR: This review focuses on recent advances in the field and highlights some of the most active areas of Jak-Stat pathway research.
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Jak2 Is Essential for Signaling through a Variety of Cytokine Receptors
Evan Parganas,Demin Wang,Dimitrios J. Stravopodis,David J. Topham,Jean-Christophe Marine,Stephan Teglund,Elio F. Vanin,Sara Bodner,Oscar R. Colamonici,Jan M. van Deursen,Gerard Grosveld,James N. Ihle +11 more
TL;DR: Reconstitution experiments demonstrate that Jak2 is not required for the generation of lymphoid progenitors, their amplification, or functional differentiation, and plays a critical, nonredundant role in the function of a specific group of cytokines receptors.
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Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.
Neil Stahl,Teri G. Boulton,Thomas Farruggella,Nancy Y. Ip,S. Davis,Bruce A. Witthuhn,Frederick W. Quelle,Olli Silvennoinen,Giovanna Barbieri,Sandra Pellegrini,James N. Ihle,George D. Yancopoulos +11 more
TL;DR: Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak- Tyk phosphorylation in different cell lines.
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