K
Kohsuke Imai
Researcher at Tokyo Medical and Dental University
Publications - 199
Citations - 7392
Kohsuke Imai is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Primary immunodeficiency & Hematopoietic stem cell transplantation. The author has an hindex of 39, co-authored 198 publications receiving 6244 citations. Previous affiliations of Kohsuke Imai include Necker-Enfants Malades Hospital & French Institute of Health and Medical Research.
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Journal ArticleDOI
Human Tyrosine Kinase 2 Deficiency Reveals Its Requisite Roles in Multiple Cytokine Signals Involved in Innate and Acquired Immunity
Yoshiyuki Minegishi,Masako Saito,Tomohiro Morio,Ken Watanabe,Kazunaga Agematsu,Shigeru Tsuchiya,Hidetoshi Takada,Toshiro Hara,Nobuaki Kawamura,Tadashi Ariga,Hideo Kaneko,Naomi Kondo,Ikuya Tsuge,Akihiro Yachie,Yukio Sakiyama,Tsutomu Iwata,Fumio Bessho,Tsutomu Oh-ishi,Kosuke Joh,Kohsuke Imai,Kazuhiro Kogawa,Miwa Shinohara,Mikiya Fujieda,Hiroshi Wakiguchi,Srdjan Pasic,Mario Abinun,Hans D. Ochs,Eleonore D. Renner,Eleonore D. Renner,Annette Jansson,Bernd H. Belohradsky,Ayse Metin,Norio Shimizu,Shuki Mizutani,Toshio Miyawaki,Shigeaki Nonoyama,Hajime Karasuyama +36 more
TL;DR: It is demonstrated that Tyk2 plays obligatory roles in multiple cytokine signals involved in innate and acquired immunity of humans, which differs substantially fromTyk2 function in mice.
Journal ArticleDOI
Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.
Kohsuke Imai,Geir Slupphaug,Wen I. Lee,Wen I. Lee,Patrick Revy,Shigeaki Nonoyama,Nadia Catalan,Leman Yel,Monique Forveille,Bodil Kavli,Hans E. Krokan,Hans D. Ochs,Alain Fischer,Alain Fischer,Anne Durandy +14 more
TL;DR: It is shown that recessive mutations of the gene encoding uracil–DNA glycosylase (UNG) are associated with profound impairment in CSR at a DNA precleavage step and with a partial disturbance of the SHM pattern in three patients with hyper-IgM syndrome.
Journal ArticleDOI
Clinical course of patients with WASP gene mutations
Kohsuke Imai,Tomohiro Morio,Yi Zhu,Yinzhu Jin,Sukeyuki Itoh,Michiko Kajiwara,Jun Ichi Yata,Shuki Mizutani,Hans D. Ochs,Shigeaki Nonoyama +9 more
TL;DR: It is demonstrated that WAS protein expression is a useful tool for predicting long-term prognosis for patients with WAS/XLT and hematopoietic stem cell transplantation should be considered, especially for WASP-negative patients, while the patients are young to improve prognosis.
Journal ArticleDOI
AID mutant analyses indicate requirement for class-switch-specific cofactors
Van-Thanh Ta,Hitoshi Nagaoka,Nadia Catalan,Anne Durandy,Alain Fischer,Kohsuke Imai,Kohsuke Imai,Shigeaki Nonoyama,Shigeaki Nonoyama,Junko Tashiro,Masaya Ikegawa,Satomi Ito,Kazuo Kinoshita,Masamichi Muramatsu,Tasuku Honjo +14 more
TL;DR: It is reported that human AID mutant proteins with insertions, replacements or truncations in the C-terminal region retained strong SHM activity but almost completely lost CSR activity, indicating that AID requires interaction with a cofactor(s) specific to CSR.
Journal ArticleDOI
Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.
Tanya I. Coulter,Anita Chandra,Chris M. Bacon,Judith Babar,James Curtis,Nicholas Screaton,John R. Goodlad,George Farmer,Cathal Laurence Steele,Timothy Ronan Leahy,Rainer Doffinger,Helen Baxendale,Jolanta Bernatoniene,J. David M. Edgar,Hilary Longhurst,Stephan Ehl,Carsten Speckmann,Bodo Grimbacher,Anna Sediva,Tomas Milota,Saul N. Faust,Anthony P. Williams,Grant Hayman,Zeynep Yesim Kucuk,Rosie Hague,Paul French,Richard Brooker,Peter Forsyth,Richard Herriot,Caterina Cancrini,Paolo Palma,Paola Ariganello,Niall Conlon,Conleth Feighery,Patrick J. Gavin,Alison Jones,Kohsuke Imai,Mohammad A. A. Ibrahim,Gašper Markelj,Mario Abinun,Frédéric Rieux-Laucat,Sylvain Latour,Isabelle Pellier,Alain Fischer,Fabien Touzot,Jean-Laurent Casanova,Anne Durandy,Siobhan O. Burns,Sinisa Savic,Dinakantha S. Kumararatne,Despina Moshous,Sven Kracker,Bart Vanhaesebroeck,Klaus Okkenhaug,Capucine Picard,Sergey Nejentsev,Alison M. Condliffe,Andrew J. Cant +57 more
TL;DR: The severity of complications in some patients supports consideration of hematopoietic stem cell transplantation for severe childhood disease and clinical trials of selective PI3K&dgr; inhibitors offer new prospects for APDS treatment.