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Silvia Mandillo
Researcher at National Research Council
Publications - 26
Citations - 1218
Silvia Mandillo is an academic researcher from National Research Council. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Dopamine. The author has an hindex of 12, co-authored 23 publications receiving 1003 citations.
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Journal ArticleDOI
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
Michelle Simon,Simon Greenaway,Jacqueline K. White,Helmut Fuchs,Valerie Gailus-Durner,Sara Wells,Tania Sorg,Kim Wong,Elodie Bedu,Elizabeth J. Cartwright,Romain Dacquin,Sophia Djebali,Jeanne Estabel,Jochen Graw,Neil J. Ingham,Ian J. Jackson,Andreas Lengeling,Silvia Mandillo,Jacqueline Marvel,Hamid Meziane,Frédéric Preitner,Oliver Puk,Michel Roux,David J. Adams,Sarah Atkins,Abdel Ayadi,Lore Becker,Andrew Blake,Debra Brooker,Heather Cater,Marie-France Champy,Roy Combe,Petr Danecek,Armida Di Fenza,Hilary Gates,Anna-Karin Gerdin,Elisabetta Golini,John M. Hancock,Wolfgang Hans,Sabine M. Hölter,Tertius Hough,Pierre Jurdic,Thomas M. Keane,Hugh P. Morgan,Werner Müller,Frauke Neff,George Nicholson,Bastian Pasche,Laura-Anne Roberson,Jan Rozman,Mark Sanderson,Luis Santos,Mohammed Selloum,Carl Shannon,Anne Southwell,Glauco P. Tocchini-Valentini,Valerie E. Vancollie,Henrik Westerberg,Wolfgang Wurst,Min Zi,Binnaz Yalcin,Binnaz Yalcin,Ramiro Ramirez-Solis,Karen P. Steel,Ann-Marie Mallon,Martin Hrabě de Angelis,Yann Herault,Steve D.M. Brown +67 more
TL;DR: Comparison of C57BL/6J and C57bl/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains.
Journal ArticleDOI
Reliability, robustness, and reproducibility in mouse behavioral phenotyping: a cross-laboratory study
Silvia Mandillo,Valter Tucci,Sabine M. Hölter,Hamid Meziane,Mumna Al Banchaabouchi,Magdalena Kallnik,Heena V. Lad,Patrick M. Nolan,Abdel-Mouttalib Ouagazzal,Emma L. Coghill,Karin Gale,Elisabetta Golini,Sylvie Jacquot,Wojtek Krezel,Andrew Parker,Fabrice Riet,Ilka Schneider,Daniela Marazziti,Johan Auwerx,Steve D.M. Brown,Pierre Chambon,Nadia Rosenthal,Glauco P. Tocchini-Valentini,Wolfgang Wurst +23 more
TL;DR: The EUMORPHIA SOPs described here are an important start-point for the ongoing development of increasingly robust phenotyping platforms and their application in large-scale, multicentre mouse phenotypes programs.
Journal ArticleDOI
MicroRNA degradation by a conserved target RNA regulates animal behavior.
Angelo Bitetti,Allison C. Mallory,Elisabetta Golini,Claudia Carrieri,Héctor Carreño Gutiérrez,Emerald Perlas,Yuvia A. Pérez-Rico,Yuvia A. Pérez-Rico,Glauco P. Tocchini-Valentini,Anton J. Enright,William H. J. Norton,Silvia Mandillo,Dónal O'Carroll,Alena Shkumatava +13 more
TL;DR: RNA-directed miRNA degradation triggered by a brain-specific genome-encoded transcript regulates explorative and anxiety-like behavior in zebrafish and affects balance and motor learning in mice.
Journal ArticleDOI
GPR37 associates with the dopamine transporter to modulate dopamine uptake and behavioral responses to dopaminergic drugs.
Daniela Marazziti,Silvia Mandillo,Chiara Di Pietro,Elisabetta Golini,Rafaele Matteoni,Glauco P. Tocchini-Valentini +5 more
TL;DR: The specific role of GPR37, a putative peptidergic G protein-coupled receptor, in modulating the functional expression of DAT and the behavioral responses to dopaminergic drugs is revealed.
Journal ArticleDOI
Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor.
Daniela Marazziti,Elisabetta Golini,Silvia Mandillo,Armando Magrelli,Walter Witke,Rafaele Matteoni,Glauco P. Tocchini-Valentini +6 more
TL;DR: The results reveal an unanticipated role of GPR37 in regulating substantia nigra-striatum dopaminergic signaling, causing resistance to treatment with the Parkinsonian neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.