V
Valerie E. Vancollie
Researcher at Wellcome Trust Sanger Institute
Publications - 21
Citations - 776
Valerie E. Vancollie is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 8, co-authored 15 publications receiving 579 citations.
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Journal ArticleDOI
A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains
Michelle Simon,Simon Greenaway,Jacqueline K. White,Helmut Fuchs,Valerie Gailus-Durner,Sara Wells,Tania Sorg,Kim Wong,Elodie Bedu,Elizabeth J. Cartwright,Romain Dacquin,Sophia Djebali,Jeanne Estabel,Jochen Graw,Neil J. Ingham,Ian J. Jackson,Andreas Lengeling,Silvia Mandillo,Jacqueline Marvel,Hamid Meziane,Frédéric Preitner,Oliver Puk,Michel Roux,David J. Adams,Sarah Atkins,Abdel Ayadi,Lore Becker,Andrew Blake,Debra Brooker,Heather Cater,Marie-France Champy,Roy Combe,Petr Danecek,Armida Di Fenza,Hilary Gates,Anna-Karin Gerdin,Elisabetta Golini,John M. Hancock,Wolfgang Hans,Sabine M. Hölter,Tertius Hough,Pierre Jurdic,Thomas M. Keane,Hugh P. Morgan,Werner Müller,Frauke Neff,George Nicholson,Bastian Pasche,Laura-Anne Roberson,Jan Rozman,Mark Sanderson,Luis Santos,Mohammed Selloum,Carl Shannon,Anne Southwell,Glauco P. Tocchini-Valentini,Valerie E. Vancollie,Henrik Westerberg,Wolfgang Wurst,Min Zi,Binnaz Yalcin,Binnaz Yalcin,Ramiro Ramirez-Solis,Karen P. Steel,Ann-Marie Mallon,Martin Hrabě de Angelis,Yann Herault,Steve D.M. Brown +67 more
TL;DR: Comparison of C57BL/6J and C57bl/6N demonstrates a range of phenotypic differences that have the potential to impact upon penetrance and expressivity of mutational effects in these strains.
Journal ArticleDOI
Mouse screen reveals multiple new genes underlying mouse and human hearing loss.
Neil J. Ingham,Selina Pearson,Valerie E. Vancollie,Victoria Rook,Morag A. Lewis,Jing Chen,Annalisa Buniello,Elisa Martelletti,Lorenzo Preite,Chi Chung Lam,Felix D. Weiss,Zӧe Powis,Pim Suwannarat,Christopher J. Lelliott,Sally J. Dawson,Jacqueline K. White,Karen P. Steel +16 more
TL;DR: A genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly generated mouse mutants using a sensitive electrophysiological test, the auditory brainstem response (ABR), reveals new molecular pathways involved in progressive hearing loss.
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Mcph1-Deficient Mice Reveal a Role for MCPH1 in Otitis Media
Jing Chen,Neil J. Ingham,Simon Clare,Claire Raisen,Valerie E. Vancollie,Ozama Ismail,Rebecca E. McIntyre,Stephen H. Tsang,Vinit B. Mahajan,Gordon Dougan,David J. Adams,Jacqueline K. White,Karen P. Steel +12 more
TL;DR: These findings revealed an unexpected phenotype, otitis media with hearing impairment, which suggests Mcph1 is a new gene underlying genetic predisposition to otitisMedia, and recapitulated the defects found in otherMcph1-deficient mice or MCPH1 patients.
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Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen
Kifayathullah Liakath-Ali,Valerie E. Vancollie,Emma Heath,Damian Smedley,Jeanne Estabel,David Sunter,Tia DiTommaso,Jacqueline K. White,Ramiro Ramirez-Solis,Ian M. Smyth,Karen P. Steel,Fiona M. Watt +11 more
TL;DR: This study analyses skin from 538 knockout mouse mutants generated by the Sanger Institute Mouse Genetics Project to create the first large-scale genome-wide tissue phenotype screen from the International Knockout Mouse Consortium and provides an open access resource for the scientific community.
Journal ArticleDOI
Development and Characterization of a Novel Animal Model of Intermittent MDMA (“Ecstasy”) Exposure during Adolescence
TL;DR: A rat model of intermittent adolescent MDMA exposure that simulates many of the features of human weekend use is developed and characterized and adolescent MDMA‐treated animals are protected against the neurotoxic and depressant effects of a subsequent MDMA “binge” challenge.