N
Nathan R. Tucker
Researcher at Broad Institute
Publications - 50
Citations - 3234
Nathan R. Tucker is an academic researcher from Broad Institute. The author has contributed to research in topics: Population & Genome-wide association study. The author has an hindex of 23, co-authored 46 publications receiving 2037 citations. Previous affiliations of Nathan R. Tucker include VA Boston Healthcare System & Massachusetts Institute of Technology.
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Journal ArticleDOI
Multi-Ethnic Genome-wide Association Study for Atrial Fibrillation
Carolina Roselli,Mark Chaffin,Lu-Chen Weng,Lu-Chen Weng,Stefanie Aeschbacher,Gustav Ahlberg,Christine M. Albert,Peter Almgren,Alvaro Alonso,Christopher D. Anderson,Christopher D. Anderson,Krishna G. Aragam,Krishna G. Aragam,Dan E. Arking,John Barnard,Traci M. Bartz,Emelia J. Benjamin,Emelia J. Benjamin,Nathan A. Bihlmeyer,Joshua C. Bis,Heather L. Bloom,Eric Boerwinkle,Erwin B. Bottinger,Jennifer A. Brody,Hugh Calkins,Archie Campbell,Thomas P. Cappola,John F. Carlquist,John F. Carlquist,Daniel I. Chasman,Daniel I. Chasman,Lin Y. Chen,Yii-Der Ida Chen,Eue Keun Choi,Seung Hoan Choi,Ingrid E. Christophersen,Ingrid E. Christophersen,Ingrid E. Christophersen,Mina K. Chung,John W. Cole,John W. Cole,David Conen,David Conen,James P. Cook,Harry J.G.M. Crijns,Michael J. Cutler,Scott M. Damrauer,Scott M. Damrauer,Brian R. Daniels,Dawood Darbar,Graciela Delgado,Joshua C. Denny,Martin Dichgans,Martin Dichgans,Marcus Dörr,Elton A. M. P. Dudink,Samuel C. Dudley,Nada Esa,Tõnu Esko,Tõnu Esko,Markku Eskola,Diane Fatkin,Diane Fatkin,Diane Fatkin,Stephan B. Felix,Ian Ford,Oscar H. Franco,Bastiaan Geelhoed,Raji P. Grewal,Raji P. Grewal,Vilmundur Gudnason,Xiuqing Guo,Namrata Gupta,Stefan Gustafsson,Rebecca Gutmann,Anders Hamsten,Tamara B. Harris,Caroline Hayward,Susan R. Heckbert,Susan R. Heckbert,Jussi Hernesniemi,Lynne J. Hocking,Albert Hofman,Andrea R. V. R. Horimoto,Jie Huang,Paul L. Huang,Jennifer E. Huffman,Erik Ingelsson,Erik Ingelsson,Esra Gucuk Ipek,Kaoru Ito,Jordi Jimenez-Conde,Jordi Jimenez-Conde,Renee Johnson,J. Wouter Jukema,Stefan Kääb,Mika Kähönen,Yoichiro Kamatani,John P. Kane,Adnan Kastrati,Sekar Kathiresan,Sekar Kathiresan,Petra Katschnig-Winter,Maryam Kavousi,Thorsten Kessler,Bas L.J.H. Kietselaer,Paulus Kirchhof,Marcus E. Kleber,Stacey Knight,Stacey Knight,José Eduardo Krieger,Michiaki Kubo,Lenore J. Launer,Jari Laurikka,Terho Lehtimäki,Kirsten Leineweber,Rozenn N. Lemaitre,Man Li,Man Li,Hong Euy Lim,Henry J. Lin,Honghuang Lin,Honghuang Lin,Lars Lind,Cecilia M. Lindgren,Marja-Liisa Lokki,Barry London,Ruth J. F. Loos,Siew-Kee Low,Yingchang Lu,Leo-Pekka Lyytikäinen,Peter W. Macfarlane,Patrik K. E. Magnusson,Anubha Mahajan,Rainer Malik,Alfredo José Mansur,Gregory M. Marcus,Lauren Margolin,Kenneth B. Margulies,Winfried März,Winfried März,David D. McManus,Olle Melander,Sanghamitra Mohanty,Jay A. Montgomery,Michael Morley,Andrew P. Morris,Martina Müller-Nurasyid,Andrea Natale,Saman Nazarian,Benjamin Neumann,Christopher Newton-Cheh,Christopher Newton-Cheh,Maartje N. Niemeijer,Kjell Nikus,Peter M. Nilsson,Raymond Noordam,Heidi Oellers,Morten S. Olesen,Marju Orho-Melander,Sandosh Padmanabhan,Hui Nam Pak,Guillaume Paré,Guillaume Paré,Nancy L. Pedersen,Joanna Pera,Alexandre C. Pereira,David J. Porteous,Bruce M. Psaty,Bruce M. Psaty,Sara L. Pulit,Sara L. Pulit,Sara L. Pulit,Clive R. Pullinger,Daniel J. Rader,Lena Refsgaard,Marta Ribasés,Marta Ribasés,Paul M. Ridker,Michiel Rienstra,Lorenz Risch,Dan M. Roden,Jonathan Rosand,Jonathan Rosand,Michael A. Rosenberg,Michael A. Rosenberg,Natalia S. Rost,Natalia S. Rost,Jerome I. Rotter,Samir Saba,Roopinder K. Sandhu,Renate B. Schnabel,Katharina Schramm,Heribert Schunkert,Claudia Schurman,Stuart A. Scott,Ilkka Seppälä,Christian M. Shaffer,Svati H. Shah,Alaa Shalaby,Alaa Shalaby,Jaemin Shim,M. Benjamin Shoemaker,Joylene E. Siland,Juha Sinisalo,Moritz F. Sinner,Agnieszka Slowik,Albert V. Smith,Blair H. Smith,J. Gustav Smith,J. Gustav Smith,Jonathan D. Smith,Nicholas L. Smith,Nicholas L. Smith,Elsayed Z. Soliman,Nona Sotoodehnia,Bruno H. Stricker,Albert Y. Sun,Han Sun,Jesper Hastrup Svendsen,Toshihiro Tanaka,Kahraman Tanriverdi,Kent D. Taylor,Maris Teder-Laving,Alexander Teumer,Sébastien Thériault,Sébastien Thériault,Stella Trompet,Nathan R. Tucker,Nathan R. Tucker,Arnljot Tveit,Arnljot Tveit,André G. Uitterlinden,Pim van der Harst,Isabelle C. Van Gelder,David R. Van Wagoner,Niek Verweij,Efthymia Vlachopoulou,Uwe Völker,Biqi Wang,Peter Weeke,Peter Weeke,Bob Weijs,Raul Weiss,Stefan Weiss,Quinn S. Wells,Kerri L. Wiggins,Jorge A. Wong,Daniel Woo,Bradford B. Worrall,Pil Sung Yang,Jie Yao,Zachary T. Yoneda,Tanja Zeller,Lingyao Zeng,Steven A. Lubitz,Steven A. Lubitz,Kathryn L. Lunetta,Kathryn L. Lunetta,Patrick T. Ellinor,Patrick T. Ellinor +260 more
TL;DR: This large, multi-ethnic genome-wide association study identifies 97 loci significantly associated with atrial fibrillation that are enriched for genes involved in cardiac development, electrophysiology, structure and contractile function.
Journal ArticleDOI
Transcriptional and Cellular Diversity of the Human Heart
Nathan R. Tucker,Mark Chaffin,Stephen J. Fleming,Amelia W. Hall,Victoria A. Parsons,Kenneth Bedi,Amer-Denis Akkad,Caroline N. Herndon,Alessandro Arduini,Irinna Papangeli,Carolina Roselli,François Aguet,Seung Hoan Choi,Kristin G. Ardlie,Mehrtash Babadi,Kenneth B. Margulies,Christian Stegmann,Patrick T. Ellinor +17 more
TL;DR: Using large-scale single nuclei RNA sequencing, the transcriptional and cellular diversity in the normal human heart was defined and the identification of discrete cell subtypes and differentially expressed genes within the heart will ultimately facilitate the development of new therapeutics for cardiovascular diseases.
Journal ArticleDOI
Large-scale analyses of common and rare variants identify 12 new loci associated with atrial fibrillation
Ingrid E. Christophersen,Ingrid E. Christophersen,Ingrid E. Christophersen,Michiel Rienstra,Carolina Roselli,Carolina Roselli,Xiaoyan Yin,Xiaoyan Yin,Bastiaan Geelhoed,John Barnard,Honghuang Lin,Honghuang Lin,Dan E. Arking,Albert V. Smith,Christine M. Albert,Mark Chaffin,Nathan R. Tucker,Nathan R. Tucker,Molong Li,Derek Klarin,Nathan A. Bihlmeyer,Siew-Kee Low,Peter Weeke,Peter Weeke,Martina Müller-Nurasyid,J. Gustav Smith,J. Gustav Smith,Jennifer A. Brody,Maartje N. Niemeijer,Marcus Dörr,Stella Trompet,Jennifer E. Huffman,Stefan Gustafsson,Claudia Schurmann,Marcus E. Kleber,Leo-Pekka Lyytikäinen,Ilkka Seppälä,Rainer Malik,Andrea R. V. R. Horimoto,Marco V Perez,Juha Sinisalo,Stefanie Aeschbacher,Sébastien Thériault,Sébastien Thériault,Jie Yao,Farid Radmanesh,Farid Radmanesh,Stefan Weiss,Alexander Teumer,Seung Hoan Choi,Lu-Chen Weng,Lu-Chen Weng,Sebastian Clauss,Sebastian Clauss,Rajat Deo,Daniel J. Rader,Svati H. Shah,Albert Y. Sun,Jemma C. Hopewell,Stéphanie Debette,Ganesh Chauhan,Ganesh Chauhan,Qiong Yang,Bradford B. Worrall,Guillaume Paré,Guillaume Paré,Yoichiro Kamatani,Yanick Hagemeijer,Niek Verweij,Joylene E. Siland,Michiaki Kubo,Jonathan D. Smith,David R. Van Wagoner,Joshua C. Bis,Siegfried Perz,Bruce M. Psaty,Bruce M. Psaty,Bruce M. Psaty,Paul M. Ridker,Jared W. Magnani,Jared W. Magnani,Tamara B. Harris,Lenore J. Launer,M. Benjamin Shoemaker,Sandosh Padmanabhan,Jeffrey Haessler,Traci M. Bartz,Melanie Waldenberger,Peter Lichtner,Marina Arendt,José Eduardo Krieger,Mika Kähönen,Lorenz Risch,Alfredo José Mansur,Annette Peters,Blair H. Smith,Lars Lind,Stuart A. Scott,Yingchang Lu,Erwin B. Bottinger,Jussi Hernesniemi,Cecilia M. Lindgren,Jorge A. Wong,Jie Huang,Markku Eskola,Andrew P. Morris,Andrew P. Morris,Ian Ford,Alexander P. Reiner,Alexander P. Reiner,Graciela Delgado,Lin Y. Chen,Yii-Der Ida Chen,Roopinder K. Sandhu,Man Li,Man Li,Eric Boerwinkle,Lewin Eisele,Lars Lannfelt,Natalia S. Rost,Natalia S. Rost,Christopher D. Anderson,Christopher D. Anderson,Kent D. Taylor,Archie Campbell,Patrik K. E. Magnusson,David J. Porteous,Lynne J. Hocking,Efthymia Vlachopoulou,Nancy L. Pedersen,Kjell Nikus,Marju Orho-Melander,Anders Hamsten,Jan Heeringa,Joshua C. Denny,Jennifer Kriebel,Dawood Darbar,Christopher Newton-Cheh,Christopher Newton-Cheh,Christian M. Shaffer,Peter W. Macfarlane,Stefanie Heilmann-Heimbach,Peter Almgren,Paul L. Huang,Nona Sotoodehnia,Elsayed Z. Soliman,André G. Uitterlinden,Albert Hofman,Oscar H. Franco,Uwe Völker,Karl-Heinz Jöckel,Moritz F. Sinner,Henry J. Lin,Xiuqing Guo,Martin Dichgans,Martin Dichgans,Erik Ingelsson,Erik Ingelsson,Charles Kooperberg,Olle Melander,Ruth J. F. Loos,Jari Laurikka,David Conen,David Conen,Jonathan Rosand,Jonathan Rosand,Pim van der Harst,Marja-Liisa Lokki,Sekar Kathiresan,Alexandre C. Pereira,J. Wouter Jukema,Caroline Hayward,Jerome I. Rotter,Winfried März,Winfried März,Terho Lehtimäki,Bruno H. Stricker,Mina K. Chung,Stephan B. Felix,Vilmundur Gudnason,Alvaro Alonso,Dan M. Roden,Stefan Kääb,Daniel I. Chasman,Daniel I. Chasman,Susan R. Heckbert,Susan R. Heckbert,Emelia J. Benjamin,Emelia J. Benjamin,Toshihiro Tanaka,Kathryn L. Lunetta,Kathryn L. Lunetta,Steven A. Lubitz,Steven A. Lubitz,Patrick T. Ellinor,Patrick T. Ellinor +195 more
TL;DR: 12 new genetic loci that exceeded genome-wide significance, implicating genes involved in cardiac electrical and structural remodeling are identified, providing insights into the molecular basis of atrial fibrillation and may facilitate the identification of new potential targets for drug discovery.
Posted ContentDOI
Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
Pascal Barbry,Christoph Muus,Christoph Muus,Malte D Luecken,Gökcen Eraslan,Avinash Waghray,Graham Heimberg,Lisa Sikkema,Yoshihiko Kobayashi,Eeshit Dhaval Vaishnav,Ayshwarya Subramanian,Christopher Smilie,Karthik A. Jagadeesh,Elizabeth Thu Duong,Evgenij Fiskin,Elena Torlai Triglia,Meshal Ansari,Peiwen Cai,Brian M. Lin,Justin Buchanan,Sijia Chen,Jian Shu,Jian Shu,Adam L. Haber,Adam L. Haber,Hattie Chung,Daniel T. Montoro,Taylor Adams,Hananeh Aliee,J. Samuel,Allon Zaneta Andrusivova,Ilias Angelidis,Orr Ashenberg,Kevin Bassler,Christophe Bécavin,Inbal Benhar,Joseph Bergenstråhle,Ludvig Bergenstråhle,Liam Bolt,Emelie Braun,Linh T. Bui,Mark Chaffin,Evgeny Chichelnitskiy,Joshua Chiou,Thomas M. Conlon,Michael S. Cuoco,Marie Deprez,David Fischer,Astrid Gillich,Joshua Gould,Minzhe Guo,Austin J. Gutierrez,Arun C. Habermann,Tyler Harvey,Peng He,Xiaomeng Hou,Xiaomeng Hou,Lijuan Hu,Alok Jaiswal,Peiyong Jiang,Theodoros Kapellos,Christin S. Kuo,Ludvig Larsson,Michael Leney-Greene,Kyungtae Lim,Monika Litviňuková,Monika Litviňuková,Ji Lu,Leif S. Ludwig,Wendy Luo,Henrike Maatz,Elo Madissoon,Lira Mamanova,Kasidet Manakongtreecheep,Kasidet Manakongtreecheep,Charles-Hugo Marquette,Ian Mbano,Alexi McAdams,Ross J. Metzger,Ahmad N. Nabhan,Sarah K. Nyquist,Lolita Penland,Olivier Poirion,Sergio Poli,Cancan Qi,Rachel Queen,Daniel Reichart,Daniel Reichart,Ivan O. Rosas,Jonas C. Schupp,Rahul Sinha,Rene Sit,Kamil Slowikowski,Kamil Slowikowski,Michal Slyper,Neal Smith,Neal Smith,Alex Sountoulidis,Maximilian Strunz,Dawei Sun,Carlos Talavera-López,Peng Tan,Jessica Tantivit,Jessica Tantivit,Kyle J. Travaglini,Nathan R. Tucker,Katherine A. Vernon,Katherine A. Vernon,Marc Wadsworth,Julia Waldman,Xiuting Wang,Wenjun Yan,William Zhao,Carly Ziegler +113 more
TL;DR: Differences in the cell type-specific expression of mediators of SARS-CoV-2 viral entry may be responsible for aspects of COVID-19 epidemiology and clinical course, and point to putative molecular pathways involved in disease susceptibility and pathogenesis.
Journal ArticleDOI
COVID-19 and Cardiovascular Disease: From Bench to Bedside.
Mina K. Chung,David A. Zidar,Michael R. Bristow,Scott J. Cameron,Timothy A. Chan,Clifford V. Harding,Deborah H. Kwon,Tamanna Singh,John C. Tilton,Emily J. Tsai,Nathan R. Tucker,John Barnard,Joseph Loscalzo +12 more
TL;DR: A review of the clinical manifestations of cardiovascular involvement, potential direct SARS-CoV-2 and indirect immune response mechanisms impacting the cardiovascular system, and implications for the management of patients after recovery from acute COVID-19 infection is provided in this article.