Animal Models of Dengue Virus Infection
Simona Zompi,Eva Harris +1 more
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TLDR
Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines.Abstract:
The development of animal models of dengue virus (DENV) infection and disease has been challenging, as epidemic DENV does not naturally infect non-human species. Non-human primates (NHPs) can sustain viral replication in relevant cell types and develop a robust immune response, but they do not develop overt disease. In contrast, certain immunodeficient mouse models infected with mouse-adapted DENV strains show signs of severe disease similar to the ‘vascular-leak’ syndrome seen in severe dengue in humans. Humanized mouse models can sustain DENV replication and show some signs of disease, but further development is needed to validate the immune response. Classically, immunocompetent mice infected with DENV do not manifest disease or else develop paralysis when inoculated intracranially; however, a new model using high doses of DENV has recently been shown to develop hemorrhagic signs after infection. Overall, each model has its advantages and disadvantages and is differentially suited for studies of dengue pathogenesis and immunopathogenesis and/or pre-clinical testing of antiviral drugs and vaccines.read more
Citations
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Dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus
Wanwisa Dejnirattisai,Piyada Supasa,Piyada Supasa,Wiyada Wongwiwat,Alexander Rouvinski,Giovanna Barba-Spaeth,Giovanna Barba-Spaeth,Thaneeya Duangchinda,Anavaj Sakuntabhai,Anavaj Sakuntabhai,Van-Mai Cao-Lormeau,Prida Malasit,Prida Malasit,Félix A. Rey,Félix A. Rey,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Gavin R. Screaton +17 more
TL;DR: Plasma immune to DENV showed substantial cross-reaction to ZIKV and was able to drive antibody-dependent enhancement (ADE) of ZikaV infection, indicating that immunity toDENV might drive greater ZikV replication and have clear implications for disease pathogenesis and future vaccine programs.
Journal ArticleDOI
DENV inhibits type I IFN production in infected cells by cleaving human STING.
Sebastian Aguirre,Ana M. Maestre,Sarah Pagni,Jenish R. Patel,Timothy Savage,Delia Gutman,Kevin Maringer,Dabeiba Bernal-Rubio,Reed S. Shabman,Viviana Simon,Juan R. Rodriguez-Madoz,Juan R. Rodriguez-Madoz,Lubbertus C. F. Mulder,Glen N. Barber,Ana Fernandez-Sesma +14 more
TL;DR: It is shown that DENV NS2B3 is not able to degrade the mouse version of STING, a phenomenon that severely restricts the replication of DENV in mouse cells, suggesting that STING plays a key role in the inhibition ofDENV infection and spread in mice.
Journal ArticleDOI
New insights into the immunopathology and control of dengue virus infection
Gavin R. Screaton,Juthathip Mongkolsapaya,Juthathip Mongkolsapaya,Sophie Yacoub,Sophie Yacoub,Catherine H Roberts +5 more
TL;DR: Recent advances in the understanding of immunopathology, vaccine development and human monoclonal antibodies produced against dengue virus are outlined.
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Aedes aegypti vector competence studies: A review.
TL;DR: This large literature including studies on the effect of the mosquito microbiota on competence is reviewed, showing that it would be a great advance in this type of research to implement standardized procedures in order to obtain comparable and reproducible results.
Emergency department management of mosquito-borne illness: malaria, dengue, and West Nile virus.
Hector Caraballo,Kevin King +1 more
TL;DR: This review discusses the diagnosis and treatment of the 3 most common mosquito-borne illnesses seen in the United States: Plasmodium falciparum malaria, dengue, and West Nile virus.
References
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