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Sowmya Chollate
Researcher at Biogen Idec
Publications - 8
Citations - 3446
Sowmya Chollate is an academic researcher from Biogen Idec. The author has contributed to research in topics: Neuroprotection & Aducanumab. The author has an hindex of 8, co-authored 8 publications receiving 2596 citations.
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Journal ArticleDOI
The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Jeff Sevigny,Ping Chiao,Thierry Bussiere,Paul H. Weinreb,Leslie Williams,Marcel Maier,Robert Dunstan,Stephen Salloway,Tianle Chen,Yan Ling,John O'Gorman,Fang Qian,Mahin Arastu,Mingwei Li,Sowmya Chollate,Melanie S. Brennan,Omar Quintero-Monzon,Robert H. Scannevin,H. Moore Arnold,Thomas Engber,Kenneth J. Rhodes,James Ferrero,Yaming Hang,Alvydas Mikulskis,Jan Grimm,Christoph Hock,Roger M. Nitsch,Alfred Sandrock +27 more
TL;DR: In patients with prodromal or mild AD, one year of monthly intravenous infusions of aducanumab reduces brain Aβ in a dose- and time-dependent manner, accompanied by a slowing of clinical decline measured by Clinical Dementia Rating—Sum of Boxes and Mini Mental State Examination scores.
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Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
Ralf A. Linker,De-Hyung Lee,Sarah Ryan,Anne M van Dam,Rebecca Conrad,Pradeep Bista,Weike Zeng,Xiaoping Hronowsky,Alex Buko,Sowmya Chollate,Gisa Ellrichmann,Wolfgang Brück,Kate Dawson,Susan Goelz,Stefan Wiese,Robert H. Scannevin,Matvey E. Lukashev,Ralf Gold +17 more
TL;DR: The ability of dimethylfumarate to activate nuclear factor (erythroid-derived 2)-related factor 2 may offer a novel cytoprotective modality that further augments the natural antioxidant responses in multiple sclerosis tissue and is not yet targeted by other multiple sclerosis therapies.
Journal ArticleDOI
Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
Robert H. Scannevin,Sowmya Chollate,Mi Young Jung,Melanie N. Shackett,Hiral Patel,Pradeep Bista,Weike Zeng,Sarah Ryan,Masayuki Yamamoto,Matvey E. Lukashev,Kenneth J. Rhodes +10 more
TL;DR: DMF and MMF are cytoprotective for neurons and astrocytes against oxidative stress-induced cellular injury and loss, potentially via up-regulation of an Nrf2-dependent antioxidant response, and these data suggest DMF andMMF may function through improving mitochondrial function.
Journal ArticleDOI
Addendum: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease
Jeff Sevigny,Ping Chiao,Thierry Bussiere,Paul H. Weinreb,Leslie Williams,Marcel Maier,Robert Dunstan,Stephen Salloway,Tianle Chen,Yan Ling,John O'Gorman,Fang Qian,Mahin Arastu,Mingwei Li,Sowmya Chollate,Melanie S. Brennan,Omar Quintero-Monzon,Robert H. Scannevin,H. Moore Arnold,Thomas Engber,Kenneth J. Rhodes,James Ferrero,Yaming Hang,Alvydas Mikulskis,Jan Grimm,Christoph Hock,Roger M. Nitsch,Alfred Sandrock +27 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, like in the previous version of this paper.
Journal ArticleDOI
Discovery of BIIB042, a Potent, Selective, and Orally Bioavailable γ-Secretase Modulator.
Hairuo Peng,Tina Talreja,Zhili Xin,J. Hernan Cuervo,Gnanasambandam Kumaravel,Michael Humora,Lin Xu,Ellen Rohde,Lawrence Gan,Mi-young Jung,Melanie N. Shackett,Sowmya Chollate,Anthone W. Dunah,Pamela A. Snodgrass-Belt,H. Moore Arnold,Arthur G. Taveras,Kenneth J. Rhodes,Robert H. Scannevin +17 more
TL;DR: Compound 10a is a potent γ-secretase modulator, which lowered Aβ42, increased Aβ38, but had little to no effect on Aβ40 levels both in vitro and in vivo, and demonstrated excellent pharmacokinetic parameters in multiple species.