S
Steffen Borrmann
Researcher at University of Tübingen
Publications - 120
Citations - 8673
Steffen Borrmann is an academic researcher from University of Tübingen. The author has contributed to research in topics: Malaria & Plasmodium falciparum. The author has an hindex of 44, co-authored 104 publications receiving 7736 citations. Previous affiliations of Steffen Borrmann include St George's Hospital & Albert Schweitzer Hospital.
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Journal ArticleDOI
Genome-wide screen identifies new candidate genes associated with artemisinin susceptibility in Plasmodium falciparum in Kenya
Steffen Borrmann,Judith Straimer,Leah Mwai,Leah Mwai,Abdirahman I. Abdi,Anja Rippert,John Okombo,Steven Muriithi,Philip Sasi,Moses Kortok,Brett Lowe,Susana Campino,Samuel Assefa,Sarah Auburn,Magnus Manske,Gareth Maslen,Norbert Peshu,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Kevin Marsh,Kevin Marsh,Alexis Nzila,Taane G. Clark +22 more
TL;DR: The results demonstrate the power of full-genome sequencing-based association studies for uncovering candidate genes that determine parasite sensitivity to artemisinins and provide a unique reference for the interpretation of results from resistant infections.
Journal ArticleDOI
The effect of food consumption on lumefantrine bioavailability in African children receiving artemether–lumefantrine crushed or dispersible tablets (Coartem®) for acute uncomplicated Plasmodium falciparum malaria
Steffen Borrmann,William M. Sallas,Sonia Machevo,Raquel González,Anders Björkman,Andreas Mårtensson,Andreas Mårtensson,Mary J. Hamel,Elizabeth Juma,Judy Peshu,Bernhards Ogutu,Abdoulaye Djimde,Umberto D'Alessandro,Anne-Claire Marrast,Gilbert Lefèvre,Steven E. Kern,Steven E. Kern +16 more
TL;DR: The effect of food intake on oral lumefantrine bioavailability in African children with malaria is evaluated.
Journal ArticleDOI
Reassessment of the resistance of Plasmodium falciparum to chloroquine in Gabon: implications for the validity of tests in vitro vs. in vivo.
Steffen Borrmann,Ronald K. Binder,A.A. Adegnika,Michel A. Missinou,Saadou Issifou,Michael Ramharter,Walther H. Wernsdorfer,Peter G. Kremsner +7 more
TL;DR: It is concluded that high level resistance of P. falciparum to chloroquine persists in the study area, highlighting the supreme value of tests in vivo in providing reliable estimates of the efficacy of an antimalarial in a specific area.
Journal ArticleDOI
Vaccine-Like Immunity against Malaria by Repeated Causal-Prophylactic Treatment of Liver-Stage Plasmodium Parasites
TL;DR: It is reported that repeated causal-prophylactic primaquine treatment of liver-stage Plasmodium parasites in rodents elicits vaccine-like protective immunity against sporozoite-induced malaria.
Journal ArticleDOI
Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis.
Richard M. Hoglund,Richard M. Hoglund,Lesley Workman,Michael D. Edstein,Nguyen Xuan Thanh,Nguyen Ngoc Quang,Issaka Zongo,Jean-Bosco Ouédraogo,Steffen Borrmann,Steffen Borrmann,Leah Mwai,Christian Nsanzabana,Ric N. Price,Ric N. Price,Prabin Dahal,Nancy C. Sambol,Sunil Parikh,François Nosten,François Nosten,Elizabeth A. Ashley,Aung Pyae Phyo,Khin Maung Lwin,Rose McGready,Rose McGready,Nicholas P. J. Day,Nicholas P. J. Day,Philippe J Guerin,Nicholas J. White,Nicholas J. White,Karen I. Barnes,Joel Tarning,Joel Tarning +31 more
TL;DR: An evidence-based optimised dose regimen was constructed that would provide piperaquine exposures across all ages comparable to the exposure currently seen in a typical adult with standard treatment, without exceeding the concentration range observed with the manufacturers’ recommended regimen.