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Stephan Wullschleger
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 28
Citations - 10456
Stephan Wullschleger is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Protein kinase B & PTEN. The author has an hindex of 18, co-authored 24 publications receiving 9618 citations. Previous affiliations of Stephan Wullschleger include ISREC & University of Dundee.
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Journal ArticleDOI
TOR signaling in growth and metabolism.
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
Journal ArticleDOI
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
Robbie Loewith,Estela Jacinto,Stephan Wullschleger,Anja Lorberg,José L. Crespo,Debora Bonenfant,Wolfgang Oppliger,Paul Jenoe,Michael N. Hall +8 more
TL;DR: Two functionally distinct TOR complexes account for the diversity, specificity, and selective rapamycin inhibition of TOR signaling.
Journal ArticleDOI
A colorectal cancer classification system that associates cellular phenotype and responses to therapy
Anguraj Sadanandam,Costas A. Lyssiotis,Costas A. Lyssiotis,Krisztian Homicsko,Krisztian Homicsko,Eric A. Collisson,William J. Gibb,Stephan Wullschleger,Liliane C Gonzalez Ostos,William A Lannon,William A Lannon,Carsten Grötzinger,Maguy Del Rio,Benoit Lhermitte,Adam B. Olshen,Bertram Wiedenmann,Lewis C. Cantley,Lewis C. Cantley,Joe W. Gray,Douglas Hanahan +19 more
TL;DR: Three subtypes have markedly better disease-free survival (DFS) after surgical resection, suggesting these patients might be spared from the adverse effects of chemotherapy when they have localized disease.
Journal ArticleDOI
Identification of Protor as a novel Rictor-binding component of mTOR complex-2
Laura R. Pearce,Xu Huang,Jérôme Boudeau,Rafał Pawłowski,Stephan Wullschleger,Maria Deak,Adel F. M. Ibrahim,Robert Gourlay,Mark A. Magnuson,Dario R. Alessi +9 more
TL;DR: It is shown that detergents such as Triton X-100 or n-octylglucoside dissociate mTOR and mLST8 from a complex of Protor-1, Sin1 and Rictor, and that ProtOr-1 is not required for the assembly of other mTORC2 subunits into a complex.
Journal ArticleDOI
Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice
Xu Huang,Stephan Wullschleger,Natalia Shpiro,Victoria A. McGuire,Kei Sakamoto,Yvonne L. Woods,Wendy Mcburnie,Stewart Fleming,Dario R. Alessi +8 more
TL;DR: The results demonstrate the potential of AMPK activators, such as clinically approved metformin, as anticancer agents, which will suppress tumour development by triggering a physiological signalling pathway that potently inhibits cell growth.