S
Stephen A. Migueles
Researcher at National Institutes of Health
Publications - 88
Citations - 12930
Stephen A. Migueles is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CD8 & Cytotoxic T cell. The author has an hindex of 41, co-authored 85 publications receiving 11969 citations.
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Journal ArticleDOI
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells
Michael R. Betts,Martha Nason,Sadie M. West,Stephen C. De Rosa,Stephen A. Migueles,Jonathan Abraham,Michael M. Lederman,Jose M. Benito,Paul A. Goepfert,Mark Connors,Mario Roederer,Richard A. Koup +11 more
TL;DR: The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.
Journal ArticleDOI
HLA B*5701 is highly associated with restriction of virus replication in a subgroup of HIV-infected long term nonprogressors.
Stephen A. Migueles,M. Shirin Sabbaghian,W. Lesley Shupert,Maria P. Bettinotti,Francesco M. Marincola,Lisa Martino,Clair W. Hallahan,Sara Selig,David C. Schwartz,John S. Sullivan,Mark Connors +10 more
TL;DR: These findings indicate that, within this phenotypically and genotypically distinct cohort, a host immune factor is highly associated with restriction of virus replication and nonprogressive disease and strongly suggest a mechanism of virus specific immunity that directly operates through the B*5701 molecule.
Journal ArticleDOI
HIV-specific CD8+ T cell proliferation is coupled to perforin expression and is maintained in nonprogressors
Stephen A. Migueles,Alisha C. Laborico,W. Lesley Shupert,M. Shirin Sabbaghian,Ronald L. Rabin,Claire W. Hallahan,Debbie van Baarle,Stefan Kostense,Frank Miedema,Mary McLaughlin,Linda A. Ehler,Julia A. Metcalf,Shuying Liu,Mark Connors +13 more
TL;DR: Results indicated that nonprogressors were differentiated by increased proliferative capacity of HIV-specific CD8+ T cells linked to enhanced effector function, and the relative absence of these functions in progressors may represent a mechanism by which HIV avoids immunological control.
Journal ArticleDOI
Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells
Jason M. Brenchley,Nitin J. Karandikar,Michael R. Betts,David R. Ambrozak,Brenna J. Hill,Laura E. Crotty,Joseph P. Casazza,Janaki Kuruppu,Stephen A. Migueles,Mark Connors,Mario Roederer,Daniel C. Douek,Richard A. Koup +12 more
TL;DR: It is found that a large proportion of HIV-specific CD8(+) T cells that produce cytokines in response to cognate antigen are unable to divide and die during a 48-hour in vitro culture.
Journal ArticleDOI
Broad and potent neutralization of HIV-1 by a gp41-specific human antibody
Jinghe Huang,Gilad Ofek,Leo B. Laub,Mark K. Louder,Nicole A. Doria-Rose,Nancy S. Longo,Hiromi Imamichi,Robert T. Bailer,Bimal K. Chakrabarti,Shailendra Kumar Sharma,S. Munir Alam,Tao Wang,Yongping Yang,Baoshan Zhang,Stephen A. Migueles,Richard T. Wyatt,Barton F. Haynes,Peter D. Kwong,John R. Mascola,Mark Connors +19 more
TL;DR: The structure of 10E8 in complex with the complete MPER revealed a site of vulnerability comprising a narrow stretch of highly conserved gp41-hydrophobic residues and a critical arginine or lysine just before the transmembrane region, suggesting the importance of these residues for neutralization.