HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells
Michael R. Betts,Martha Nason,Sadie M. West,Stephen C. De Rosa,Stephen A. Migueles,Jonathan Abraham,Michael M. Lederman,Jose M. Benito,Paul A. Goepfert,Mark Connors,Mario Roederer,Richard A. Koup +11 more
TLDR
The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.About:
This article is published in Blood.The article was published on 2006-06-15 and is currently open access. It has received 1825 citations till now. The article focuses on the topics: HIV vaccine & Viral load.read more
Citations
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T cell exhaustion
TL;DR: Advances in the molecular delineation of T cell exhaustion are clarifying the underlying causes of this state of differentiation and also suggest promising therapeutic opportunities.
Journal ArticleDOI
Taking dendritic cells into medicine
TL;DR: Some medical implications of DC biology that account for illness and provide opportunities for prevention and therapy are presented.
Journal ArticleDOI
Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection
Shawn D. Blackburn,Haina Shin,W. Nicholas Haining,W. Nicholas Haining,Tao Zou,Creg J. Workman,Antonio Polley,Michael R. Betts,Gordon J. Freeman,Dario A. A. Vignali,E. John Wherry +10 more
TL;DR: It is shown that exhausted CD8+ T cells are subject to complex layers of negative regulation resulting from the coexpression of multiple inhibitory receptors, and regulation of T cell exhaustion by various inhibitory pathways was nonredundant.
Journal ArticleDOI
Robust T Cell Immunity in Convalescent Individuals with Asymptomatic or Mild COVID-19.
Takuya Sekine,André Perez-Potti,Olga Rivera-Ballesteros,Kristoffer Strålin,Jean Baptiste Gorin,Annika Olsson,Sian Llewellyn-Lacey,Habiba Kamal,Gordana Bogdanovic,Sandra Muschiol,David J. Wullimann,Tobias Kammann,Johanna Emgård,Tiphaine Parrot,Elin Folkesson,Olav Rooyackers,Lars Eriksson,Jan-Inge Henter,Anders Sönnerborg,Tobias Allander,Jan Albert,Morten Nielsen,Jonas Klingström,Sara Gredmark-Russ,Niklas K. Björkström,Johan K. Sandberg,David Price,Hans-Gustaf Ljunggren,Soo Aleman,Marcus Buggert +29 more
TL;DR: It is shown that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Journal ArticleDOI
T-cell quality in memory and protection: implications for vaccine design
TL;DR: The importance of using multiparameter flow cytometry to better understand the functional capacity of effector and memory T-cell responses, thereby enabling the development of preventative and therapeutic vaccine strategies for infections is highlighted.
References
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Journal ArticleDOI
Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome.
Richard A. Koup,Jeffrey T. Safrit,Yunzhen Cao,C. A. Andrews,G. Mcleod,William Borkowsky,C. Farthing,David D. Ho +7 more
TL;DR: It is suggested that cellular immunity is involved in the initial control of virus replication in primary HIV-1 infection and a role for CTL in protective immunity to HIV- 1 in vivo is indicated.
Journal ArticleDOI
Control of Viremia in Simian Immunodeficiency Virus Infection by CD8+ Lymphocytes
Jörn E. Schmitz,Marcelo J. Kuroda,Sampa Santra,Vito G. Sasseville,Meredith A. Simon,Michelle A. Lifton,Paul Racz,Klara Tenner-Racz,Margaret Dalesandro,Bernhard J. Scallon,John Ghrayeb,Meryl A. Forman,David C. Montefiori,E. Peter Rieber,Norman L. Letvin,Keith A. Reimann +15 more
TL;DR: The results confirm the importance of cell-mediated immunity in controlling HIV-1 infection and support the exploration of vaccination approaches for preventing infection that will elicit these immune responses.
Journal ArticleDOI
Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection.
TL;DR: HIV-1-specific CTL activity is a major component of the host immune response associated with the control of virus replication following primary HIV-1 infection and have important implications for the design of antiviral vaccines.
Journal ArticleDOI
Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation
Michael R. Betts,Jason M. Brenchley,David Price,Stephen C. De Rosa,Daniel C. Douek,Mario Roederer,Richard A. Koup +6 more
TL;DR: A novel technique to enumerate antigen-specific CD8+ T cells using a marker expressed on the cell surface following activation induced degranulation, a necessary precursor of cytolysis, and CD107-expressing CD8+, expressing cognate T cell receptors (TCR), is presented.
Journal ArticleDOI
Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA.
Graham S. Ogg,Xia Jin,Sebastian Bonhoeffer,P R Dunbar,Martin A. Nowak,Simon Monard,Jeremy P. Segal,Yunzhen Cao,Sarah Rowland-Jones,Vincenzo Cerundolo,Arlene Hurley,M. Markowitz,David D. Ho,Douglas F. Nixon,Andrew J. McMichael +14 more
TL;DR: With the use of the tetrameric complexes, a significant inverse correlation was observed between HIV-specific CTL frequency and plasma RNA viral load and suggest a considerable cytopathic effect of the virus in vivo.
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