S
Sadie M. West
Researcher at Vaccine Research Center
Publications - 4
Citations - 2289
Sadie M. West is an academic researcher from Vaccine Research Center. The author has contributed to research in topics: CD8 & T cell. The author has an hindex of 4, co-authored 4 publications receiving 2192 citations.
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Journal ArticleDOI
HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+ T-cells
Michael R. Betts,Martha Nason,Sadie M. West,Stephen C. De Rosa,Stephen A. Migueles,Jonathan Abraham,Michael M. Lederman,Jose M. Benito,Paul A. Goepfert,Mark Connors,Mario Roederer,Richard A. Koup +11 more
TL;DR: The quality of the HIV-specific CD8(+) T-cell functional response serves as an immune correlate of HIV disease progression and a potential qualifying factor for evaluation of HIV vaccine efficacy.
Journal ArticleDOI
T Cell Receptor Recognition Motifs Govern Immune Escape Patterns in Acute SIV Infection
David Price,Sadie M. West,Michael R. Betts,Laura E. Ruff,Jason M. Brenchley,David R. Ambrozak,Yvette Edghill-Smith,Marcelo J. Kuroda,Derek Bogdan,Kevin J. Kunstman,Norman L. Letvin,Genoveffa Franchini,Steven M. Wolinsky,Richard A. Koup,Daniel C. Douek +14 more
TL;DR: Analysis of 3416 SIV-specific TCR sequences revealed that polyclonal T cell populations characterized by highly conserved TCRB CDR3 motifs were rendered ineffectual by single residue mutations in the cognate viral epitope, directing the pattern of adaptive viral evolution.
Journal ArticleDOI
Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection
Michael R. Betts,Barbara Exley,David Price,Anju Bansal,Zenaido T. Camacho,Vanessa Teaberry,Sadie M. West,David R. Ambrozak,Georgia D. Tomaras,Mario Roederer,J. Michael Kilby,Jim Tartaglia,Robert B. Belshe,Feng Gao,Daniel C. Douek,Kent J. Weinhold,Richard A. Koup,Paul A. Goepfert,Guido Ferrari +18 more
TL;DR: Control of HIV by vaccine-elicited HIV-specific T cell responses may be difficult, even when the T cell response has those characteristics predicted to provide optimal protection.
Journal ArticleDOI
Interleukin-15 but Not Interleukin-7 Abrogates Vaccine-Induced Decrease in Virus Level in Simian Immunodeficiency Virusmac251-Infected Macaques
Anna Hryniewicz,Anna Hryniewicz,David Price,Marcin Moniuszko,Marcin Moniuszko,Adriano Boasso,Yvette Edghill-Spano,Yvette Edghill-Spano,Sadie M. West,David Venzon,Monica Vaccari,Wen-Po Tsai,Elzbieta Tryniszewska,Elzbieta Tryniszewska,Janos Nacsa,Francois Villinger,Aftab A. Ansari,Christopher Trindade,Michel Morre,David G. Brooks,Philip A. Arlen,Helen Brown,Christina M. R. Kitchen,Jerome A. Zack,Daniel C. Douek,Gene M. Shearer,Mark G. Lewis,Richard A. Koup,Genoveffa Franchini +28 more
TL;DR: The impact of IL-7 and IL-15 treatment on viral replication and the immunogenicity of live poxvirus vaccines in SIVmac251-infected macaques is assessed.