M
Matthew S. Block
Researcher at Mayo Clinic
Publications - 127
Citations - 2918
Matthew S. Block is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Cancer & Medicine. The author has an hindex of 23, co-authored 108 publications receiving 2120 citations.
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Journal ArticleDOI
Integrated Genomic Characterization Reveals Novel, Therapeutically Relevant Drug Targets in FGFR and EGFR Pathways in Sporadic Intrahepatic Cholangiocarcinoma
Mitesh J. Borad,Mia D. Champion,Jan B. Egan,Winnie S. Liang,Rafael Fonseca,Alan H. Bryce,Ann E. McCullough,Michael T. Barrett,Michael T. Barrett,Katherine S. Hunt,Maitray D. Patel,Scott W. Young,Joseph M. Collins,Alvin C. Silva,Rachel M. Condjella,Matthew S. Block,Robert R. McWilliams,Konstantinos N. Lazaridis,Eric W. Klee,Keith C. Bible,Pamela E. Harris,Gavin R. Oliver,Jaysheel D. Bhavsar,Asha Nair,Sumit Middha,Yan W. Asmann,Jean Pierre A. Kocher,Kimberly A. Schahl,Benjamin R. Kipp,Emily G. Barr Fritcher,Angela Baker,Jessica Aldrich,Ahmet Kurdoglu,Tyler Izatt,Alexis Christoforides,Irene Cherni,Sara Nasser,Rebecca Reiman,Lori Phillips,Jackie McDonald,Jonathan Adkins,Stephen D. Mastrian,Pamela Placek,Aprill Watanabe,Janine LoBello,Haiyong Han,Daniel D. Von Hoff,Daniel D. Von Hoff,David Craig,A. Keith Stewart,John D. Carpten +50 more
TL;DR: FGFR2 fusions and ERRFI mutations may represent novel targets in sporadic intrahepatic cholangiocarcinoma and trials should be characterized in larger cohorts of patients with these aberrations.
Journal ArticleDOI
Dose-Response Association of CD8(+) Tumor-Infiltrating Lymphocytes and Survival Time in High-Grade Serous Ovarian Cancer
Ellen L. Goode,Matthew S. Block,Kimberly R. Kalli,Robert A. Vierkant,Wenqian Chen,Zachary C. Fogarty,Aleksandra Gentry-Maharaj,A. Toloczko,Alexander Hein,Aliecia L. Bouligny,Aliecia L. Bouligny,Allan Jensen,Ana Osorio,Andreas D. Hartkopf,Andy Ryan,Anita Chudecka-Głaz,Anthony M. Magliocco,Arndt Hartmann,Audrey Y. Jung,Bo Gao,Brenda Y. Hernandez,Brooke L. Fridley,Bryan M. McCauley,Catherine J. Kennedy,Catherine J. Kennedy,Chen Wang,Chloe Karpinskyj,Christiani Bisinoto de Sousa,Daniel Guimarães Tiezzi,David L. Wachter,Esther Herpel,Florin Andrei Taran,Francesmary Modugno,Gregg Nelson,Jan Lubinski,Janusz Menkiszak,Jennifer Alsop,Jenny Lester,Jesús García-Donas,Jill Nation,Jillian Hung,Jillian Hung,José Palacios,Joseph H. Rothstein,Joseph L. Kelley,Jurandyr Moreira de Andrade,Luis Robles-Díaz,Maria P. Intermaggio,Martin Widschwendter,Matthias W. Beckmann,Matthias Ruebner,Mercedes Jimenez-Linan,Naveena Singh,Oleg Oszurek,Paul R. Harnett,Peter F Rambau,Peter F Rambau,Peter Sinn,Philipp Wagner,Prafull Ghatage,Raghwa Sharma,Raghwa Sharma,Robert P. Edwards,Roberta B. Ness,Sandra Orsulic,Sara Y. Brucker,Sharon E. Johnatty,Teri A. Longacre,Ursula Eilber,Valerie McGuire,Weiva Sieh,Yanina Natanzon,Zheng Li,Zheng Li,Alice S. Whittemore,Anna deFazio,Anna deFazio,Annette Staebler,Beth Y. Karlan,Blake Gilks,David D.L. Bowtell,David D.L. Bowtell,David D.L. Bowtell,Estrid Høgdall,Francisco José Candido dos Reis,Helen Steed,Ian G. Campbell,Ian G. Campbell,Jacek Gronwald,Javier Benitez,Jennifer M Koziak,Jenny Chang-Claude,Jenny Chang-Claude,Kirsten B. Moysich,Linda E. Kelemen,Linda S. Cook,Marc T. Goodman,Maria J. Garcia,Peter A. Fasching,Peter A. Fasching,Stefan Kommoss,Suha Deen,Susanne K. Kjaer,Usha Menon,James D. Brenton,Paul D.P. Pharoah,Georgia Chenevix-Trench,David G. Huntsman,David G. Huntsman,Stacey J. Winham,Martin Köbel,Susan J. Ramus,Susan J. Ramus +112 more
TL;DR: This study demonstrates the histotype-specific nature of immune infiltration and provides definitive evidence for a dose-response relationship between CD8+ TILs and HGSOC survival and suggests that understanding factors that drive infiltration will be the key to unraveling outcome heterogeneity in this cancer.
Journal ArticleDOI
Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer
Hui Shen,Brooke L. Fridley,Honglin Song,Kate Lawrenson,Julie M. Cunningham,Susan J. Ramus,Mine S. Cicek,Jonathan Tyrer,Douglas A. Stram,Melissa C. Larson,Martin Köbel,Argyrios Ziogas,Wei Zheng,Hannah P. Yang,Anna H. Wu,Eva Wozniak,Yin Ling Woo,Boris Winterhoff,Elisabeth Wik,Alice S. Whittemore,Nicolas Wentzensen,Rachel Palmieri Weber,Allison F. Vitonis,Daniel Vincent,Robert A. Vierkant,Ignace Vergote,Ignace Vergote,David Van Den Berg,Anne M. van Altena,Shelley S. Tworoger,Pamela J. Thompson,Daniel C. Tessier,Kathryn L. Terry,Soo Hwang Teo,Claire Templeman,Daniel O. Stram,Melissa C. Southey,Weiva Sieh,Nadeem Siddiqui,Yurii B. Shvetsov,Xiao-Ou Shu,Viji Shridhar,Shan Wang-Gohrke,Gianluca Severi,Gianluca Severi,Ira Schwaab,Helga B. Salvesen,Iwona K. Rzepecka,Ingo B. Runnebaum,Mary Anne Rossing,Mary Anne Rossing,Lorna Rodriguez-Rodriguez,Harvey A. Risch,Stefan P. Renner,Elizabeth M. Poole,Malcolm C. Pike,Malcolm C. Pike,Catherine M. Phelan,Liisa M. Pelttari,Tanja Pejovic,James Paul,Irene Orlow,Siti Zawiah Omar,Sara H. Olson,Kunle Odunsi,Stefan Nickels,Heli Nevanlinna,Roberta B. Ness,Steven A. Narod,Toru Nakanishi,Kirsten B. Moysich,Alvaro N.A. Monteiro,Joanna Moes-Sosnowska,Francesmary Modugno,Usha Menon,John R. McLaughlin,Valerie McGuire,Keitaro Matsuo,Noor Azmi Mat Adenan,Leon F.A.G. Massuger,Galina Lurie,Lene Lundvall,Jan Lubinski,Jolanta Lissowska,Douglas A. Levine,Arto Leminen,Alice W. Lee,Nhu D. Le,Sandrina Lambrechts,Sandrina Lambrechts,Diether Lambrechts,Jolanta Kupryjanczyk,Camilla Krakstad,Gottfried E. Konecny,Susanne K. Kjaer,Lambertus A. Kiemeney,Linda E. Kelemen,Linda E. Kelemen,Gary L. Keeney,Beth Y. Karlan,Rod Karevan,Kimberly R. Kalli,Hiroaki Kajiyama,Bu Tian Ji,Allan Jensen,Anna Jakubowska,Edwin S. Iversen,Satoyo Hosono,Claus Høgdall,Estrid Høgdall,Maureen E. Hoatlin,Peter Hillemanns,Florian Heitz,Rebecca Hein,Rebecca Hein,Philipp Harter,Mari K. Halle,Per Hall,Jacek Gronwald,Martin Gore,Marc T. Goodman,Graham G. Giles,Graham G. Giles,Graham G. Giles,Aleksandra Gentry-Maharaj,Montserrat Garcia-Closas,James M. Flanagan,Peter A. Fasching,Peter A. Fasching,Arif B. Ekici,Robert Edwards,Diana Eccles,Douglas F. Easton,Matthias Dürst,Andreas du Bois,Thilo Dörk,Jennifer A. Doherty,Evelyn Despierre,Evelyn Despierre,Agnieszka Dansonka-Mieszkowska,Cezary Cybulski,Daniel W. Cramer,Linda S. Cook,Xiaoqing Chen,Bridget Charbonneau,Jenny Chang-Claude,Ian G. Campbell,Ian G. Campbell,Ralf Bützow,Clareann H. Bunker,Doerthe Brueggmann,Robert S. Brown,Angela Brooks-Wilson,Louise A. Brinton,Natalia Bogdanova,Matthew S. Block,Elizabeth Benjamin,Jonathan Beesley,Matthias W. Beckmann,Elisa V. Bandera,Laura Baglietto,Laura Baglietto,Francois Bacot,Sebastian M. Armasu,Natalia Antonenkova,Hoda Anton-Culver,Katja K.H. Aben,Dong Liang,Xifeng Wu,Karen H. Lu,Michelle A.T. Hildebrandt,Joellen M. Schildkraut,Thomas A. Sellers,David G. Huntsman,Andrew Berchuck,Georgia Chenevix-Trench,Simon A. Gayther,Paul D.P. Pharoah,Peter W. Laird,Ellen L. Goode,Celeste Leigh Pearce +180 more
TL;DR: Different variants in HNF1B associate with risk of serous and clear cell epithelial ovarian cancer; DNA methylation and expression patterns are also notably distinct between these subtypes.
Journal ArticleDOI
Oncolytic Measles Virus Expressing the Sodium Iodide Symporter to Treat Drug-Resistant Ovarian Cancer
Evanthia Galanis,Pamela J. Atherton,Matthew J. Maurer,Keith L. Knutson,Sean C. Dowdy,William A. Cliby,Paul Haluska,Harry J. Long,Ann L. Oberg,Ileana Aderca,Matthew S. Block,Jamie N. Bakkum-Gamez,Mark J. Federspiel,Stephen J. Russell,Kimberly R. Kalli,Gary L. Keeney,Kah-Whye Peng,Lynn C. Hartmann +17 more
TL;DR: Immune monitoring posttreatment showed an increase in effector T cells recognizing the tumor antigens IGFBP2 and FRα, indicating that MV-NIS treatment triggered cellular immunity against the patients' tumor and suggesting that an immune mechanism mediating the observed antitumor effect was mediated.
Journal ArticleDOI
Neoadjuvant systemic therapy in melanoma: recommendations of the International Neoadjuvant Melanoma Consortium
Rodabe N. Amaria,Alexander M. Menzies,Alexander M. Menzies,Alexander M. Menzies,Elizabeth M. Burton,Richard A. Scolyer,Richard A. Scolyer,Michael T. Tetzlaff,Robert Antdbacka,Charlotte E. Ariyan,Roland L. Bassett,Brett W. Carter,Adil Daud,Mark B. Faries,Leslie A. Fecher,Keith T. Flaherty,Jeffrey E. Gershenwald,Omid Hamid,Angela Hong,Angela Hong,John M. Kirkwood,Serigne Lo,Kim Margolin,Jane L. Messina,Michael A. Postow,Michael A. Postow,Helen Rizos,Helen Rizos,Merrick I. Ross,Elisa A. Rozeman,Robyn P. M. Saw,Robyn P. M. Saw,Robyn P. M. Saw,Vernon K. Sondak,Ryan J. Sullivan,Janis M. Taube,John F. Thompson,John F. Thompson,John F. Thompson,Bart A. van de Wiel,Alexander M.M. Eggermont,Michael A. Davies,Miles C. Andrews,Donald A. Berry,Matthew S. Block,Genevieve M. Boland,Kathryn Bollin,Matteo S. Carlino,Richard D. Carvajal,Jonathan Cohen,Diwakar Davar,Keith A. Delman,Reinhard Dummer,Michael D. Farwell,David E. Fisher,Alberto Fusi,Isabella C. Glitza,Tanja D. de Gruijl,David E. Gyorki,Axel Hauschild,Tina J. Hieken,James Larkin,David H. Lawson,Céleste Lebbé,Jeffrey E. Lee,Michael C. Lowe,Jason J. Luke,Grant A. McArthur,David F. McDermott,Jennifer L. McQuade,Tara C. Mitchell,Teresa M. Petrella,Peter A. Prieto,Igor Puzanov,Caroline Robert,April K.S. Salama,Shaneen Sandhu,Dirk Schadendorf,Alexander N. Shoushtari,Jeffrey A. Sosman,Susan M. Swetter,Ken K. Tanabe,Samra Turajlic,Douglas S. Tyler,Scott E. Woodman,Frances C. Wright,Jonathan S. Zager,Paolo A. Ascierto,Andrew J. Spillane,Andrew J. Spillane,Andrew J. Spillane,Alexander C.J. van Akkooi,Jennifer A. Wargo,Christian U. Blank,Hussein Abdul-Hassan Tawbi,Georgina V. Long,Georgina V. Long,Georgina V. Long +97 more
TL;DR: The International Neoadjuvant Melanoma Consortium is established with experts in medical oncology, surgical oncologist, pathology, radiation oncologists, radiology, and translational research to develop recommendations for investigating neoadjuant therapy in melanoma to align future trial designs and correlative analyses.